Genetic investigation of fibromuscular dysplasia identifies risk loci and shared genetics with common cardiovascular diseases.

Adult Arteries Cardiovascular Diseases / complications Cytoskeletal Proteins / genetics Female Fibroblasts Fibromuscular Dysplasia / complications Gene Expression Regulation Genome-Wide Association Study Humans Intracranial Aneurysm Low Density Lipoprotein Receptor-Related Protein-1 / genetics Male Microfilament Proteins / genetics Middle Aged Plasma Membrane Calcium-Transporting ATPases / genetics Sodium-Calcium Exchanger / genetics Transcriptome

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
15 10 2021
Historique:
received: 10 11 2020
accepted: 17 09 2021
entrez: 16 10 2021
pubmed: 17 10 2021
medline: 16 11 2021
Statut: epublish

Résumé

Fibromuscular dysplasia (FMD) is an arteriopathy associated with hypertension, stroke and myocardial infarction, affecting mostly women. We report results from the first genome-wide association meta-analysis of six studies including 1556 FMD cases and 7100 controls. We find an estimate of SNP-based heritability compatible with FMD having a polygenic basis, and report four robustly associated loci (PHACTR1, LRP1, ATP2B1, and LIMA1). Transcriptome-wide association analysis in arteries identifies one additional locus (SLC24A3). We characterize open chromatin in arterial primary cells and find that FMD associated variants are located in arterial-specific regulatory elements. Target genes are broadly involved in mechanisms related to actin cytoskeleton and intracellular calcium homeostasis, central to vascular contraction. We find significant genetic overlap between FMD and more common cardiovascular diseases and traits including blood pressure, migraine, intracranial aneurysm, and coronary artery disease.

Identifiants

DOI: 10.1038/s41467-021-26174-2 PMID: 34654805 PMC: PMC8521585
pubmed: 34654805
doi: 10.1038/s41467-021-26174-2
pii: 10.1038/s41467-021-26174-2
pmc: PMC8521585
doi:

Substances chimiques

ATP2B1 protein, human 0
Cytoskeletal Proteins 0
LIMA1 protein, human 0
LRP1 protein, human 0
Low Density Lipoprotein Receptor-Related Protein-1 0
Microfilament Proteins 0
PHACTR1 protein, human 0
SLC24A3 protein, human 0
Sodium-Calcium Exchanger 0
Plasma Membrane Calcium-Transporting ATPases EC 3.6.3.8

Types de publication

Journal Article Meta-Analysis Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6031

Subventions

Organisme : NCRR NIH HHS
ID : UL1 RR024989
Pays : United States
Organisme : NHLBI NIH HHS
ID : K24 HL137010
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002548
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL122684
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL086694
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL161016
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139672
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL148167
Pays : United States

Investigateurs

Peter de Leeuw (P)

Commentaires et corrections

Type : ErratumIn

Informations de copyright

© 2021. The Author(s).

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Auteurs

Adrien Georges (A)

PARCC, INSERM, Université de Paris, F-750015, Paris, France.
ORCID: 0000-0003-4208-2393

Min-Lee Yang (ML)

Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA.

Takiy-Eddine Berrandou (TE)

PARCC, INSERM, Université de Paris, F-750015, Paris, France.
ORCID: 0000-0002-0525-3002

Mark K Bakker (MK)

Department of Neurology and Neurosurgery, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.
ORCID: 0000-0002-7887-9014

Ozan Dikilitas (O)

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, 55902, USA.
ORCID: 0000-0002-9906-8608

Soto Romuald Kiando (SR)

PARCC, INSERM, Université de Paris, F-750015, Paris, France.

Lijiang Ma (L)

Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Benjamin A Satterfield (BA)

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, 55902, USA.

Sebanti Sengupta (S)

Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.

Mengyao Yu (M)

PARCC, INSERM, Université de Paris, F-750015, Paris, France.

Jean-François Deleuze (JF)

Centre National de Recherche en Génomique Humaine, Institut de Génomique, CEA and Fondation Jean Dausset-CEPH, Evry, France.
ORCID: 0000-0002-5358-4463

Delia Dupré (D)

PARCC, INSERM, Université de Paris, F-750015, Paris, France.

Kristina L Hunker (KL)

Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA.

Sergiy Kyryachenko (S)

PARCC, INSERM, Université de Paris, F-750015, Paris, France.

Lu Liu (L)

PARCC, INSERM, Université de Paris, F-750015, Paris, France.

Ines Sayoud-Sadeg (I)

PARCC, INSERM, Université de Paris, F-750015, Paris, France.

Laurence Amar (L)

PARCC, INSERM, Université de Paris, F-750015, Paris, France.
Hypertension Unit, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, F-75015, Paris, France.

Chad M Brummett (CM)

Department of Anesthesiology, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.

Dawn M Coleman (DM)

Vascular Surgery Section, Department of Surgery, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.

Valentina d'Escamard (V)

Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Peter de Leeuw (P)

Department of Internal Medicine, Division of General Internal Medicine, Section Vascular Medicine, Maastricht University Medical Centre, Maastricht University, Maastricht, the Netherlands.
CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre, Maastricht University, Maastricht, the Netherlands.
ORCID: 0000-0002-4949-5812

Natalia Fendrikova-Mahlay (N)

Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.

Daniella Kadian-Dodov (D)

Zena and Michael A. Wiener Cardiovascular Institute and Marie-Josée and Henry R, Kravis Center for Cardiovascular Health Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Jun Z Li (JZ)

Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA.
ORCID: 0000-0001-6727-0812

Aurélien Lorthioir (A)

PARCC, INSERM, Université de Paris, F-750015, Paris, France.
Hypertension Unit, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, F-75015, Paris, France.

Marco Pappaccogli (M)

Division of Cardiology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, 1200, Brussels, Belgium.
Division of Internal Medicine and Hypertension Unit, Department of Medical Sciences, University of Turin, Turin, Italy.

Aleksander Prejbisz (A)

Department of Hypertension, National Institute of Cardiology, Warsaw, Poland.

Witold Smigielski (W)

Department of Demography, University of Lodz, Lodz, Poland.

James C Stanley (JC)

Vascular Surgery Section, Department of Surgery, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.

Matthew Zawistowski (M)

Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
ORCID: 0000-0002-3005-083X

Xiang Zhou (X)

Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
ORCID: 0000-0002-4331-7599

Sebastian Zöllner (S)

Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Philippe Amouyel (P)

Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Labex DISTALZ - Risk factors and molecular determinants of aging-related disease, F-59000, Lille, France.
ORCID: 0000-0001-9088-234X

Marc L De Buyzere (ML)

Department of Cardiovascular Diseases, Ghent University and Ghent University Hospital, Ghent, Belgium.

Stéphanie Debette (S)

Department of Neurology, Bordeaux University Hospital, Inserm U1219, Bordeaux, France.
ORCID: 0000-0001-8675-7968

Piotr Dobrowolski (P)

Department of Hypertension, National Institute of Cardiology, Warsaw, Poland.

Wojciech Drygas (W)

Department of Epidemiology, Cardiovascular Disease Prevention, and Health Promotion, National Institute of Cardiology, Warsaw, Poland.

Heather L Gornik (HL)

Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
ORCID: 0000-0002-5849-4010

Jeffrey W Olin (JW)

Zena and Michael A. Wiener Cardiovascular Institute and Marie-Josée and Henry R, Kravis Center for Cardiovascular Health Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0003-3374-616X

Jerzy Piwonski (J)

Department of Epidemiology, Cardiovascular Disease Prevention, and Health Promotion, National Institute of Cardiology, Warsaw, Poland.

Ernst R Rietzschel (ER)

Department of Cardiovascular Diseases, Ghent University and Ghent University Hospital, Ghent, Belgium.

Ynte M Ruigrok (YM)

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, 55902, USA.
ORCID: 0000-0002-5396-2989

Miikka Vikkula (M)

Human Molecular Genetics, de Duve Institute, Université Catholique de Louvain, 1200, Brussels, Belgium.
ORCID: 0000-0002-6236-338X

Ewa Warchol Celinska (E)

Department of Hypertension, National Institute of Cardiology, Warsaw, Poland.
ORCID: 0000-0002-6757-2527

Andrzej Januszewicz (A)

Department of Hypertension, National Institute of Cardiology, Warsaw, Poland.

Iftikhar J Kullo (IJ)

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, 55902, USA.
Gonda Vascular Center, Mayo Clinic, Rochester, MN, 55902, USA.
ORCID: 0000-0002-6524-3471

Michel Azizi (M)

Hypertension Unit, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, F-75015, Paris, France.
Université de Paris, Inserm, Centre d'Investigation Clinique 1418, F-75006, Paris, France.

Xavier Jeunemaitre (X)

PARCC, INSERM, Université de Paris, F-750015, Paris, France.
Department of Genetics, Assistance-Publiques-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, F-75015, Paris, France.
ORCID: 0000-0001-5925-381X

Alexandre Persu (A)

Division of Cardiology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, 1200, Brussels, Belgium.
Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, 1200, Brussels, Belgium.

Jason C Kovacic (JC)

Zena and Michael A. Wiener Cardiovascular Institute and Marie-Josée and Henry R, Kravis Center for Cardiovascular Health Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia.
St. Vincent's Clinical School, University of New South Wales, Sydney, NSW, Australia.

Santhi K Ganesh (SK)

Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA. sganesh@med.umich.edu.
Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA. sganesh@med.umich.edu.
ORCID: 0000-0002-3663-5249

Nabila Bouatia-Naji (N)

PARCC, INSERM, Université de Paris, F-750015, Paris, France. nabila.bouatia-naji@inserm.fr.
ORCID: 0000-0001-5424-2134

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Genetic investigation of fibromuscular...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Artères › Genetic investigation of fibromuscular...
questionsmedicales.fr › Maladies cardiovasculaires › Genetic investigation of fibromuscular...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Genetic investigation of fibromuscular...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Genetic investigation of fibromuscular...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Artériopathies oblitérantes › Dysplasie fibromusculaire › Genetic investigation of fibromuscular...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Genetic investigation of fibromuscular...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Genetic investigation of fibromuscular...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genetic investigation of fibromuscular...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Artériopathies intracrâniennes › Anévrysme intracrânien › Genetic investigation of fibromuscular...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux lipoprotéines › Récepteurs aux lipoprotéines LDL › Protéines apparentées au récepteur LDL › Protéine-1 apparentée au récepteur des LDL › Genetic investigation of fibromuscular...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Genetic investigation of fibromuscular...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Genetic investigation of fibromuscular...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › P-type ATPases › Calcium-Transporting ATPases › Plasma Membrane Calcium-Transporting ATPases › Genetic investigation of fibromuscular...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Antiports › Échangeur sodium-calcium › Genetic investigation of fibromuscular...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Genetic investigation of fibromuscular...