Elevated serum levels of methylglyoxal are associated with impaired liver function in patients with liver cirrhosis.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
15 10 2021
15 10 2021
Historique:
received:
07
07
2021
accepted:
06
10
2021
entrez:
16
10
2021
pubmed:
17
10
2021
medline:
28
1
2022
Statut:
epublish
Résumé
Methylglyoxal (MGO) is a highly reactive dicarbonyl species that forms advanced glycation end products (AGEs). The binding of these AGEs to their receptor (RAGE) causes and sustains severe inflammation. Systemic inflammation is postulated to be a major driver in the progression of liver cirrhosis. However, the role of circulating MGO levels in liver cirrhosis remains unknown. In this study, we investigated the serum levels of two dicarbonyl species, MGO and glyoxal (GO) using tandem mass spectrometry (HPLC-MS/MS) and evaluated their association with disease severity. A total of 51 inpatients and outpatients with liver cirrhosis of mixed etiology and different disease stages were included. Elevated MGO levels were seen in an advanced stage of liver cirrhosis (p < 0.001). High MGO levels remained independently associated with impaired liver function, as assessed by the model for end-stage liver disease (MELD) (β = 0.448, p = 0.002) and acute decompensation (AD) (β = 0.345, p = 0.005) scores. Furthermore, MGO was positively correlated with markers of systemic inflammation (IL-6, p = 0.004) and the development of ascites (p = 0.013). In contrast, no changes were seen in GO serum levels. Circulating levels of MGO are elevated in advanced stages of liver cirrhosis and are associated with impaired liver function and liver-related parameters.
Identifiants
pubmed: 34654829
doi: 10.1038/s41598-021-00119-7
pii: 10.1038/s41598-021-00119-7
pmc: PMC8519993
doi:
Substances chimiques
Pyruvaldehyde
722KLD7415
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
20506Informations de copyright
© 2021. The Author(s).
Références
Dis Markers. 2018 Feb 11;2018:8735926
pubmed: 29606988
Science. 2019 Jan 11;363(6423):
pubmed: 30630899
J Hepatol. 2018 Aug;69(2):406-460
pubmed: 29653741
Cells. 2019 Jul 19;8(7):
pubmed: 31331077
J Hepatol. 2015 Nov;63(5):1272-84
pubmed: 26192220
J Hepatol. 2005;42 Suppl(1):S100-7
pubmed: 15777564
Front Oncol. 2019 Aug 20;9:785
pubmed: 31482070
Physiol Rev. 2020 Jan 1;100(1):407-461
pubmed: 31539311
J Hepatol. 2002 Jan;36(1):66-71
pubmed: 11804666
Br J Surg. 1973 Aug;60(8):646-9
pubmed: 4541913
Diabetes. 1999 Jan;48(1):198-202
pubmed: 9892243
Gut. 2020 Jun;69(6):1127-1138
pubmed: 32102926
Liver Transpl. 2006 Mar;12(3):440-7
pubmed: 16498643
Int J Mol Sci. 2017 Nov 20;18(11):
pubmed: 29156655
Nat Protoc. 2014 Aug;9(8):1969-79
pubmed: 25058644
Int J Legal Med. 2013 Mar;127(2):385-93
pubmed: 22820652
Aliment Pharmacol Ther. 2019 Nov;50(10):1112-1119
pubmed: 31583743
Int J Biol Macromol. 2018 Jul 1;113:269-276
pubmed: 29481950
Clin Chem Lab Med. 2014 Jan 1;52(1):85-91
pubmed: 23492564
J Hepatol. 2015 Apr;62(4):831-40
pubmed: 25463539
Exp Biol Med (Maywood). 2013 Apr;238(4):360-9
pubmed: 23760001
Diabetes. 2016 Aug;65(8):2282-94
pubmed: 27207552
Eur Biophys J. 2016 Sep;45(6):523-34
pubmed: 27017355
Lancet. 2014 May 17;383(9930):1749-61
pubmed: 24480518
Biochem J. 1990 Jul 1;269(1):1-11
pubmed: 2198020
Chem Biol Interact. 2011 May 30;191(1-3):322-9
pubmed: 21334317
J Hepatol. 2012 Mar;56(3):647-55
pubmed: 21907687
J Hepatol. 2020 Jul;73(1):186-201
pubmed: 32240716
Diabetes. 2009 Nov;58(11):2486-97
pubmed: 19651811
J Hepatol. 2020 Apr;72(4):688-701
pubmed: 31778751
PLoS One. 2017 Feb 23;12(2):e0171260
pubmed: 28231326
Lancet. 2021 Oct 9;398(10308):1359-1376
pubmed: 34543610
J Hepatol. 2018 Mar;68(3):563-576
pubmed: 29111320
BMC Med. 2014 Sep 18;12:145
pubmed: 25242656
IUBMB Life. 2016 Feb;68(2):156-66
pubmed: 26748578
Proteome Sci. 2018 Feb 14;16:4
pubmed: 29456458
J Hepatol. 2004 Dec;41(6):913-9
pubmed: 15582123
Gastroenterology. 2014 Oct;147(4):765-783.e4
pubmed: 25046161
Amino Acids. 2012 Apr;42(4):1133-42
pubmed: 20963454
Kidney Int. 2018 Apr;93(4):803-813
pubmed: 29477239
Nat Immunol. 2020 May;21(5):555-566
pubmed: 32327756
Clin Gastroenterol Hepatol. 2018 May;16(5):730-737
pubmed: 28919544
J Hepatol. 2021 Mar;74(3):670-685
pubmed: 33301825
N Engl J Med. 2008 Sep 4;359(10):1018-26
pubmed: 18768945
Mediators Inflamm. 2013;2013:501430
pubmed: 23766560