Impact of human papillomavirus on the tumor microenvironment in oropharyngeal squamous cell carcinoma.
RNA-seq
human papillomavirus
oropharyngeal cancer
tumor microenvironment
Journal
International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124
Informations de publication
Date de publication:
01 02 2022
01 02 2022
Historique:
revised:
27
09
2021
received:
15
04
2021
accepted:
30
09
2021
pubmed:
17
10
2021
medline:
17
2
2022
entrez:
16
10
2021
Statut:
ppublish
Résumé
Increasing evidence has elucidated the clinicopathological significance of tumor microenvironment (TME) cells. However, TME differences associated with human papillomavirus (HPV) infection in oropharyngeal squamous cell carcinoma (OPSCC) have not been well characterized. In our study, we comprehensively determined the TME infiltration patterns in 315 OPSCC patients, and systematically correlated the TME phenotypes with genomic characteristics and clinical features of OPSCCs. In this way, we observed the enrichment of high endothelial cells and adaptive immune cells in HPV-positive (HPV+) OPSCCs, in contrast to the enrichment of fibroblasts and capillary endothelial cells in HPV- negative (HPV-) OPSCCs. By focusing on immune checkpoint genes, we constructed a coexpression network using genes that were differentially expressed between HPV+ and HPV- OPSCCs. Functional analysis of the network indicated that HPV+ OPSCCs had elevated immune activities by promoting adaptive immune response and suppressing activities related to extracellular matrix organization. Subsequently, clinical analysis showed that identified TME-relevant genes were closely associated with the prognosis and therapy response in OPSCC. Importantly, results from the TME analysis were further validated using an independent OPSCC cohort.
Identifiants
pubmed: 34655477
doi: 10.1002/ijc.33849
pmc: PMC8665085
mid: NIHMS1748919
doi:
Substances chimiques
Immune Checkpoint Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
521-531Subventions
Organisme : NCI NIH HHS
ID : K07 CA218247
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA233873
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE026471
Pays : United States
Informations de copyright
© 2021 UICC.
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