Antibody dependent enhancement: Unavoidable problems in vaccine development.
Antibody-dependent infection enhancement
Coronavirus
Vaccine
Journal
Advances in immunology
ISSN: 1557-8445
Titre abrégé: Adv Immunol
Pays: United States
ID NLM: 0370425
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
17
10
2021
pubmed:
18
10
2021
medline:
29
10
2021
Statut:
ppublish
Résumé
In some cases, antibodies can enhance virus entry and replication in cells. This phenomenon is called antibody-dependent infection enhancement (ADE). ADE not only promotes the virus to be recognized by the target cell and enters the target cell, but also affects the signal transmission in the target cell. Early formalin-inactivated virus vaccines such as aluminum adjuvants (RSV and measles) have been shown to induce ADE. Although there is no direct evidence that there is ADE in COVID-19, this potential risk is a huge challenge for prevention and vaccine development. This article focuses on the virus-induced ADE phenomenon and its molecular mechanism. It also summarizes various attempts in vaccine research and development to eliminate the ADE phenomenon, and proposes to avoid ADE in vaccine development from the perspective of antigens and adjuvants.
Identifiants
pubmed: 34656289
pii: S0065-2776(21)00029-8
doi: 10.1016/bs.ai.2021.08.003
pmc: PMC8438590
pii:
doi:
Substances chimiques
Antibodies, Viral
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
99-133Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
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