The damage effect of heat stress and psychological stress combined exposure on uterus in female rats.

Explore the effects of heat stress and psychological stress combined exposure on the uterus and its underlying mechanisms. Sixty female Sprague-Dawley rats were randomly assigned to four groups: control group, psychological stress group, high ambient temperature group, and high ambient temperature combined with psychological stress group. All treatments were administered for two weeks. During this period, the estrous cycle, body weights and rectal temperature were measured regularly. Then, ovarian weight coefficient, serum estradiol (E High temperature combined with psychological stress lead to body weight, body temperature, ovarian hormones and estrus cycle disorder, uterine gland ducts expansion and endometrial thickness reduction, and the decreased expression of endometrial receptivity markers (LIF and HoxA10). Further, disturbed expression of E This will provide the scientific basis for improving female reproductive health, and preventing and treating reproductive disorders.

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