Multi-walled carbon nanotubes trigger lysosome-dependent cell death (pyroptosis) in macrophages but not in neutrophils.

Animals Cell Death Inflammasomes / metabolism Interleukin-1beta / metabolism Lysosomes / metabolism Macrophages / metabolism Nanotubes, Carbon / toxicity Neutrophils Pyroptosis
Carbon nanotubes gasdermin D lysosomes macrophage neutrophil pyroptosis

Journal

Nanotoxicology
ISSN: 1743-5404
Titre abrégé: Nanotoxicology
Pays: England
ID NLM: 101233132

Informations de publication

Date de publication:
11 2021
Historique:
pubmed: 19 10 2021
medline: 17 3 2022
entrez: 18 10 2021
Statut: ppublish

Résumé

Carbon nanotubes (CNTs) have been extensively investigated, and several studies have shown that multi-walled CNTs can trigger inflammation and fibrosis in animal models. However, while neutrophils are involved in inflammation, most

Identifiants

DOI: 10.1080/17435390.2021.1988171 PMID: 34657549
pubmed: 34657549
doi: 10.1080/17435390.2021.1988171
doi:

Substances chimiques

Inflammasomes 0
Interleukin-1beta 0
Nanotubes, Carbon 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1125-1150

Auteurs

Sandeep Keshavan (S)

Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Govind Gupta (G)

Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Sebastin Martin (S)

Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Bengt Fadeel (B)

Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Multi-walled carbon nanotubes trigger...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Multi-walled carbon nanotubes trigger...
questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › Inflammasomes › Multi-walled carbon nanotubes trigger...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Monokines › Interleukine-1 › Interleukine-1 bêta › Multi-walled carbon nanotubes trigger...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Lysosomes › Multi-walled carbon nanotubes trigger...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Multi-walled carbon nanotubes trigger...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanotubes › Nanotubes de carbone › Multi-walled carbon nanotubes trigger...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Granulocytes neutrophiles › Multi-walled carbon nanotubes trigger...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Pyroptose › Multi-walled carbon nanotubes trigger...