Excitatory and inhibitory receptors utilize distinct post- and trans-synaptic mechanisms in vivo.
cell elimination
excitatory
in vivo
inhibitory
mouse
neuroscience
postsynaptic
receptor
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
18 10 2021
18 10 2021
Historique:
received:
03
06
2020
accepted:
19
09
2021
pubmed:
19
10
2021
medline:
19
11
2021
entrez:
18
10
2021
Statut:
epublish
Résumé
Ionotropic neurotransmitter receptors at postsynapses mediate fast synaptic transmission upon binding of the neurotransmitter. Post- and trans-synaptic mechanisms through cytosolic, membrane, and secreted proteins have been proposed to localize neurotransmitter receptors at postsynapses. However, it remains unknown which mechanism is crucial to maintain neurotransmitter receptors at postsynapses. In this study, we ablated excitatory or inhibitory neurons in adult mouse brains in a cell-autonomous manner. Unexpectedly, we found that excitatory AMPA receptors remain at the postsynaptic density upon ablation of excitatory presynaptic terminals. In contrast, inhibitory GABA
Identifiants
pubmed: 34658339
doi: 10.7554/eLife.59613
pii: 59613
pmc: PMC8550753
doi:
pii:
Substances chimiques
Receptors, AMPA
0
Receptors, GABA-A
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NINDS NIH HHS
ID : F32 NS093952
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH115705
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD105352
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH125772
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH077939
Pays : United States
Organisme : NIMH NIH HHS
ID : R56 MH077939
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS113600
Pays : United States
Informations de copyright
© 2021, Miyazaki et al.
Déclaration de conflit d'intérêts
TM, MM, CB, KK, YN, TY, MV, PC, MW, ST No competing interests declared
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