Macrolipasemia secondary to colon cancer chemotherapy: a case report.
capecitabine
chemotherapy
macrolipasemia
oxaliplatin
pancreatitis
Journal
Biochemia medica
ISSN: 1846-7482
Titre abrégé: Biochem Med (Zagreb)
Pays: Croatia
ID NLM: 9610305
Informations de publication
Date de publication:
15 Oct 2021
15 Oct 2021
Historique:
received:
18
06
2021
accepted:
29
08
2021
entrez:
18
10
2021
pubmed:
19
10
2021
medline:
26
10
2021
Statut:
ppublish
Résumé
We reported macrolipasemia in a colon cancer patient during the chemotherapy period without any evidence of pancreatitis. A 52-year-old man formerly treated for papillary thyroid carcinoma had elevated a carcinoembryonic antigen (CEA) concentration in the latest control and was diagnosed with colon cancer. Xelox chemotherapy (oxaliplatin and capecitabine) protocol was planned for six months. Interestingly, the lipase activities gradually increased from 30 U/L to 434 U/L, and exceeded three times the upper limit of the reference range (13-60 U/L). There were no symptoms of pancreatitis, and the abdominal computed tomography (CT) scan was also normal. Polyethylene glycol (PEG) recovery % values of serum samples gradually decreased and were 27% in the recent sample before the end of chemotherapy. Interestingly, the serum lipase activity fell a month after chemotherapy, and PEG recovery % increased (39%). We considered the following possibilities: (1) macrolipasemia due to chemotherapy drugs, (2) macrolipasemia due to antibodies against chemotherapy drugs.
Identifiants
pubmed: 34658648
doi: 10.11613/BM.2021.030801
pii: bm-31-3-030801
pmc: PMC8495620
doi:
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
030801Informations de copyright
Croatian Society of Medical Biochemistry and Laboratory Medicine.
Déclaration de conflit d'intérêts
Potential conflict of interest None declared.
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