allergen
allergic rhinitis
asthma
mRNA
Journal
Postepy dermatologii i alergologii
ISSN: 1642-395X
Titre abrégé: Postepy Dermatol Alergol
Pays: Poland
ID NLM: 101168357
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
13
01
2020
accepted:
01
04
2020
entrez:
18
10
2021
pubmed:
19
10
2021
medline:
19
10
2021
Statut:
ppublish
Résumé
Allergen-specific immunotherapy (AIT) is the core treatment in allergic rhinitis and asthma. Although widely used, some patients do not benefit from treatment and there is no efficacy objective marker. To define the profile of gene transcripts during the build-up phase of AIT and their comparison to the control group and then search for a viable efficacy marker in relation to patient symptoms. AIT was administered in 22 patients allergic to grass pollen. Analysis of 15 selected transcript expression was performed in whole blood samples taken before AIT (sample A) and after reaching the maintenance dose (sample B). The control group included 25 healthy volunteers (sample C). The primary endpoint was Relative Quantification. The gene expression analysis was followed by clinical evaluation with the use of Allergy Control Score (ACS). Comparison between samples A and B of gene expression showed a significant increase in There is a significant change in the expression of
Identifiants
pubmed: 34658711
doi: 10.5114/ada.2021.108925
pii: 45086
pmc: PMC8501422
doi:
Types de publication
Journal Article
Langues
eng
Pagination
665-672Informations de copyright
Copyright: © 2021 Termedia Sp. z o. o.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Clin Chem. 2009 Apr;55(4):611-22
pubmed: 19246619
J Allergy Clin Immunol. 2017 Dec;140(6):1485-1498
pubmed: 29221580
J Allergy Clin Immunol. 2013 Mar;131(3):875-85
pubmed: 23265862
Allergy. 2008 Nov;63(11):1455-63
pubmed: 18925882
J Exp Med. 2006 Aug 7;203(8):1891-901
pubmed: 16831897
Curr Opin Allergy Clin Immunol. 2004 Aug;4(4):313-8
pubmed: 15238798
J Allergy Clin Immunol. 2014 Mar;133(3):621-31
pubmed: 24581429
Allergy. 2011 May;66(5):629-36
pubmed: 21261656
Nature. 1984 Jun 28-Jul 4;309(5971):799-801
pubmed: 6429546
J Hum Genet. 2014 Aug;59(8):437-43
pubmed: 25056814
Am J Reprod Immunol. 2015 May;73(5):445-59
pubmed: 25491384
Int Arch Allergy Immunol. 2012;159(3):287-96
pubmed: 22722803
Nat Rev Mol Cell Biol. 2011 Jun 23;12(7):413-26
pubmed: 21697900
J Clin Invest. 1993 Aug;92(2):644-51
pubmed: 8349803
J Transl Med. 2014 Jan 25;12:24
pubmed: 24460842
J Allergy Clin Immunol. 2008 Jun;121(6):1467-72, 1472.e1
pubmed: 18423565
Clin Exp Allergy. 2012 Dec;42(12):1745-55
pubmed: 23181790
Allergy. 2011 Jun;66(6):725-32
pubmed: 21466562
J Immunol. 2004 Jun 1;172(11):6938-43
pubmed: 15153513
J Immunol. 1985 Oct;135(4):2513-7
pubmed: 3928753
J Allergy Clin Immunol. 2011 Dec;128(6):1153-62
pubmed: 21824648
Allergy. 2012 Feb;67(2):217-26
pubmed: 22077562
J Immunol. 1983 Nov;131(5):2542-4
pubmed: 6313807
Cell. 2003 Jan 24;112(2):169-80
pubmed: 12553906
J Allergy Clin Immunol. 2017 Oct;140(4):950-958
pubmed: 28602936
Nat Immunol. 2014 Jan;15(1):15-25
pubmed: 24352326
Nat Rev Mol Cell Biol. 2010 May;11(5):329-41
pubmed: 20379207
Trends Immunol. 2006 Apr;27(4):183-7
pubmed: 16527542
J Immunol. 1986 Feb 1;136(3):949-54
pubmed: 2934482
J Allergy Clin Immunol. 2016 Feb;137(2):358-68
pubmed: 26853128
Allergy. 2012 Dec;67(12):1594-600
pubmed: 23066930
World Allergy Organ J. 2015 May 14;8(1):17
pubmed: 26023323
Immunology. 2004 Aug;112(4):669-73
pubmed: 15270739
Cytokine Growth Factor Rev. 2009 Apr;20(2):97-113
pubmed: 19268625
J Allergy Clin Immunol. 2015 Mar;135(3):771-80.e8
pubmed: 25240783
J Biol Chem. 1998 May 1;273(18):10919-25
pubmed: 9556569
Ann Allergy Asthma Immunol. 2011 Jun;106(6):502-10
pubmed: 21624750
Annu Rev Immunol. 2001;19:683-765
pubmed: 11244051
J Allergy Clin Immunol. 2012 Nov;130(5):1153-1158.e2
pubmed: 22698521
Pediatr Allergy Immunol. 2010 Feb;21(1 Pt 2):e166-73
pubmed: 19682278
Sci Rep. 2016 Feb 26;6:22081
pubmed: 26916970
J Allergy Clin Immunol. 2012 Nov;130(5):1108-1116.e6
pubmed: 23021882
Blood. 2003 Jan 1;101(1):143-50
pubmed: 12393446
PLoS One. 2013 Jun 18;8(6):e66468
pubmed: 23824597
Eur J Cell Biol. 2011 May;90(5):376-89
pubmed: 21333378
Ann Immunol (Paris). 1980 May-Jun;131C(3):349-61
pubmed: 6157349
J Allergy Clin Immunol. 2014 Jan;133(1):130-8.e1-2
pubmed: 24290282
J Allergy Clin Immunol. 2010 May;125(5):1092-7
pubmed: 20334904
J Allergy Clin Immunol. 2016 Jun;137(6):1733-1741
pubmed: 26915677
Immunity. 2012 Oct 19;37(4):660-73
pubmed: 23041064
Genes Immun. 2014 Dec;15(8):511-20
pubmed: 25056447
Wien Klin Wochenschr. 2016 Aug;128(15-16):541-54
pubmed: 27370268
Immunol Rev. 2010 Sep;237(1):55-71
pubmed: 20727029
Inflammation. 2014 Dec;37(6):1945-56
pubmed: 24865466