Optimization of
CD4+ TEM cells
Kv1.3 blocker
Pichia pastoris
margatoxin
patch-clamp
recombinant expression
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2021
2021
Historique:
received:
30
06
2021
accepted:
30
08
2021
entrez:
18
10
2021
pubmed:
19
10
2021
medline:
19
10
2021
Statut:
epublish
Résumé
Margatoxin (MgTx) is a high-affinity blocker of voltage-gated potassium (Kv) channels. It inhibits Kv1.1-Kv1.3 ion channels in picomolar concentrations. This toxin is widely used to study physiological function of Kv ion channels in various cell types, including immune cells. Isolation of native MgTx in large quantities from scorpion venom is not affordable. Chemical synthesis and recombinant production in
Identifiants
pubmed: 34658872
doi: 10.3389/fphar.2021.733610
pii: 733610
pmc: PMC8511391
doi:
Types de publication
Journal Article
Langues
eng
Pagination
733610Informations de copyright
Copyright © 2021 Naseem, Tajti, Gaspar, Szanto, Borrego and Panyi.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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