DNA Double Strand Break Repair Pathways in Response to Different Types of Ionizing Radiation.
DNA repair pathway
combination therapy
double strand break repair
end resection
linear energy transfer
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2021
2021
Historique:
received:
08
07
2021
accepted:
30
08
2021
entrez:
18
10
2021
pubmed:
19
10
2021
medline:
19
10
2021
Statut:
epublish
Résumé
The superior dose distribution of particle radiation compared to photon radiation makes it a promising therapy for the treatment of tumors. However, the cellular responses to particle therapy and especially the DNA damage response (DDR) is not well characterized. Compared to photons, particles are thought to induce more closely spaced DNA lesions instead of isolated lesions. How this different spatial configuration of the DNA damage directs DNA repair pathway usage, is subject of current investigations. In this review, we describe recent insights into induction of DNA damage by particle radiation and how this shapes DNA end processing and subsequent DNA repair mechanisms. Additionally, we give an overview of promising DDR targets to improve particle therapy.
Identifiants
pubmed: 34659358
doi: 10.3389/fgene.2021.738230
pmc: PMC8514742
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
738230Informations de copyright
Copyright © 2021 van de Kamp, Heemskerk, Kanaar and Essers.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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