Evolution of Clinical Trials in Ovarian Cancer Management over the Past 20 Years: Never Settle Down, Always Go Beyond.
Journal
Journal of oncology
ISSN: 1687-8450
Titre abrégé: J Oncol
Pays: Egypt
ID NLM: 101496537
Informations de publication
Date de publication:
2021
2021
Historique:
received:
03
07
2021
accepted:
17
09
2021
entrez:
18
10
2021
pubmed:
19
10
2021
medline:
19
10
2021
Statut:
epublish
Résumé
A practice synthesis of available evidence-based medicine data in ovarian cancer (OC), aiming to provide directions for future research. We performed a systematic review. PubMed was searched for relevant OC trials between January 2000 and December 2019. Out of 865 references screened, 199 trials were found eligible for inclusion. Most trials were multicenter (83.9%). There was a trend reduction in the number of patients enrolled/per study over the years. Studies testing targeted/biological therapies dominated the second decade (60 trials in 2010-2019 versus 2 trials in 2000-2009). The proportion of trials with positive survival and clinical outcomes significantly increased from 23.8% in early 2000s to 54.1% in the last 5 years. Trials with histology/molecular biomarker criteria were more likely to meet progression-free survival endpoint than those without these selection criteria (69.2% versus 32.6%). This systematic review suggests a trend of increased positive studies, mainly linked to precision medicine.
Identifiants
pubmed: 34659406
doi: 10.1155/2021/1682532
pmc: PMC8516526
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1682532Informations de copyright
Copyright © 2021 Francesca De Felice et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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