Side effects of omeprazole: a system biology study.
Network analysis
Omeprazole
System biology
Journal
Gastroenterology and hepatology from bed to bench
ISSN: 2008-2258
Titre abrégé: Gastroenterol Hepatol Bed Bench
Pays: Iran
ID NLM: 101525875
Informations de publication
Date de publication:
2021
2021
Historique:
received:
24
04
2021
accepted:
29
07
2021
entrez:
18
10
2021
pubmed:
19
10
2021
medline:
19
10
2021
Statut:
ppublish
Résumé
To assess the effects of omeprazole on the human cardiovascular system is the main aim of this study. Omeprazole as a proton pump inhibitor is widely consumed to inhibit gastric acid secretion. Gene expression profiles of "human coronary artery endothelial cells" in the absence and presence of omeprazole were downloaded from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) interacted as an interactome, and the hub nodes are determined. The DEGs were enriched via gene ontology (GO) analysis. The critical hubs were identified based on the GO findings. Among 103 queried DEGs, 61 individuals were included in the main connected component. CTNNB1, HNRNPA1, SRSF4, TRA2A, SFPQ, and RBM5 genes were identified as critical hub genes. Six clusters of biological terms were introduced as deregulated elements in the presence of omeprazole. In conclusion, long-term consumption of omeprazole may be accompanied with undesirable effects, however more evidence is required.
Sections du résumé
AIM
OBJECTIVE
To assess the effects of omeprazole on the human cardiovascular system is the main aim of this study.
BACKGROUND
BACKGROUND
Omeprazole as a proton pump inhibitor is widely consumed to inhibit gastric acid secretion.
METHODS
METHODS
Gene expression profiles of "human coronary artery endothelial cells" in the absence and presence of omeprazole were downloaded from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) interacted as an interactome, and the hub nodes are determined. The DEGs were enriched via gene ontology (GO) analysis. The critical hubs were identified based on the GO findings.
RESULTS
RESULTS
Among 103 queried DEGs, 61 individuals were included in the main connected component. CTNNB1, HNRNPA1, SRSF4, TRA2A, SFPQ, and RBM5 genes were identified as critical hub genes. Six clusters of biological terms were introduced as deregulated elements in the presence of omeprazole.
CONCLUSION
CONCLUSIONS
In conclusion, long-term consumption of omeprazole may be accompanied with undesirable effects, however more evidence is required.
Types de publication
Journal Article
Langues
eng
Pagination
334-341Informations de copyright
©2021 RIGLD, Research Institute for Gastroenterology and Liver Diseases.
Déclaration de conflit d'intérêts
The authors declare that they have no conflict of interest.
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