Utilization Trends and Predictors of Non-invasive and Invasive Ventilation During Hospitalization Due to Community-Acquired Pneumonia.

community acquired pneumonia invasive mechanical ventilation non-invasive ventilation outcomes trends

Journal

Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737

Informations de publication

Date de publication:
Sep 2021
Historique:
accepted: 14 09 2021
entrez: 18 10 2021
pubmed: 19 10 2021
medline: 19 10 2021
Statut: epublish

Résumé

Community-acquired pneumonia (CAP) is associated with significant morbidity and mortality. Non-invasive ventilation (NIV) and invasive mechanical ventilation (IMV) are most important interventions for patients with severe CAP associated with respiratory failure. We analysed utilization trends and predictors of non-invasive and invasive ventilation in patients hospitalized with CAP.  Nationwide Inpatient Sample and Healthcare Cost and Utilization Project data for years 2008-2017 were analysed. Adult hospitalizations due to CAP were identified by previously validated International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) and International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) codes. We then utilized the Cochran-Armitage trend test and multivariate survey logistic regression models to analyse temporal incidence trends, predictors, and outcomes. We used SAS 9.4 software (SAS Institute Inc., Cary, NC, USA) for analysing data. Out of a total of 8,385,861 hospitalizations due to CAP, ventilation assistance was required in 552,395 (6.6%). The overall ventilation use increased slightly; however, IMV utilization decreased, while NIV utilization increased. In multivariable regression analysis, males, Asian/others and weekend admissions were associated with higher odds of any ventilation utilization. Concurrent diagnoses of septicemia, congestive heart failure, alcoholism, chronic lung diseases, pulmonary circulatory diseases, diabetes mellitus, obesity and cancer were associated with increased odds of requiring ventilation assistance. Ventilation requirement was associated with high odds of in-hospital mortality and discharge to facility. The use of NIV among CAP patients has increased while IMV use has decreased over the years. We observed numerous factors linked with a higher use of ventilation support. The requirement of ventilation support is also associated with very high chances of mortality and morbidity.

Sections du résumé

BACKGROUND BACKGROUND
Community-acquired pneumonia (CAP) is associated with significant morbidity and mortality. Non-invasive ventilation (NIV) and invasive mechanical ventilation (IMV) are most important interventions for patients with severe CAP associated with respiratory failure. We analysed utilization trends and predictors of non-invasive and invasive ventilation in patients hospitalized with CAP.
METHODS METHODS
 Nationwide Inpatient Sample and Healthcare Cost and Utilization Project data for years 2008-2017 were analysed. Adult hospitalizations due to CAP were identified by previously validated International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) and International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) codes. We then utilized the Cochran-Armitage trend test and multivariate survey logistic regression models to analyse temporal incidence trends, predictors, and outcomes. We used SAS 9.4 software (SAS Institute Inc., Cary, NC, USA) for analysing data.
RESULTS RESULTS
Out of a total of 8,385,861 hospitalizations due to CAP, ventilation assistance was required in 552,395 (6.6%). The overall ventilation use increased slightly; however, IMV utilization decreased, while NIV utilization increased. In multivariable regression analysis, males, Asian/others and weekend admissions were associated with higher odds of any ventilation utilization. Concurrent diagnoses of septicemia, congestive heart failure, alcoholism, chronic lung diseases, pulmonary circulatory diseases, diabetes mellitus, obesity and cancer were associated with increased odds of requiring ventilation assistance. Ventilation requirement was associated with high odds of in-hospital mortality and discharge to facility.
CONCLUSION CONCLUSIONS
The use of NIV among CAP patients has increased while IMV use has decreased over the years. We observed numerous factors linked with a higher use of ventilation support. The requirement of ventilation support is also associated with very high chances of mortality and morbidity.

Identifiants

pubmed: 34660142
doi: 10.7759/cureus.17954
pmc: PMC8515501
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e17954

Informations de copyright

Copyright © 2021, Shah et al.

Déclaration de conflit d'intérêts

The authors have declared that no competing interests exist.

Références

Postgrad Med. 2015 Aug;127(6):607-15
pubmed: 26224210
Tanaffos. 2014;13(4):20-8
pubmed: 25852758
Crit Care. 2011 Jul 25;15(4):R174
pubmed: 21787387
Med Care. 1988 Nov;26(11):1111-4
pubmed: 3141726
Clin Respir J. 2016 Jan;10(1):98-103
pubmed: 25043135
Korean J Intern Med. 2007 Sep;22(3):157-63
pubmed: 17939332
J Crit Care. 2015 Feb;30(1):49-54
pubmed: 25449883
Breathe (Sheff). 2016 Dec;12(4):328-340
pubmed: 28270863
Pneumonia (Nathan). 2020 Jul 25;12:6
pubmed: 32724760
N Engl J Med. 2014 Dec 11;371(24):2298-308
pubmed: 25494269
Am J Public Health. 1998 Jul;88(7):1089-92
pubmed: 9663160
Respir Med. 2014 Aug;108(8):1214-22
pubmed: 24898129
Arthritis Care Res (Hoboken). 2013 Aug;65(8):1343-57
pubmed: 23335588
Clin Infect Dis. 2017 May 15;64(suppl_2):S141-S144
pubmed: 28475780
Eur J Intern Med. 2012 Jul;23(5):420-8
pubmed: 22726370
Epidemiol Infect. 2008 Feb;136(2):232-40
pubmed: 17445319
Eur J Intern Med. 2019 Jun;64:e8
pubmed: 31202478
Am J Respir Crit Care Med. 2000 Jul;162(1):119-25
pubmed: 10903230
Eur J Intern Med. 2017 May;40:64-71
pubmed: 27979670
Am J Med. 2001 Apr 15;110(6):451-7
pubmed: 11331056
J Rural Health. 2004 Fall;20(4):394-400
pubmed: 15551857
Med Care. 2002 Jun;40(6):530-9
pubmed: 12021679
BMJ Open. 2018 Jun 19;8(6):e020857
pubmed: 29921683
Am J Emerg Med. 2018 Mar;36(3):347-351
pubmed: 28802543
Crit Care Med. 2017 Mar;45(3):e246-e254
pubmed: 27749319
Am J Emerg Med. 2018 Apr;36(4):720
pubmed: 29276029
Clin Med Circ Respirat Pulm Med. 2008 Apr 18;2:19-25
pubmed: 21157518
Thorax. 2011 Jan;66(1):66-73
pubmed: 20980246

Auteurs

Harshil Shah (H)

Internal Medicine, Guthrie Robert Packer Hospital, Sayre, USA.

Jude ElSaygh (J)

Internal Medicine, University of Debrecen, Debrecen, HUN.

Abdur Raheem (A)

Internal Medicine, Texas Tech University Health Sciences Center at Permian Basin, Odessa, USA.

Mohammed A Yousuf (MA)

General Medicine, Gleneagles Global Hospitals, Hyderabad, IND.

Lac Han Nguyen (LH)

Internal Medicine, University of Medicine and Pharmacy of Ho Chi Minh City, Ho Chi Minh City, VNM.

Pratiksha S Nathani (PS)

Internal Medicine, Maharashtra University of Health Sciences, Nashik, IND.

Venus Sharma (V)

Internal Medicine, Punjab Institute of Medical Sciences, Jalandhar, IND.

Abhinay Theli (A)

Internal Medicine, Guthrie Cortland Medical Center, Cortland, USA.

Maheshkumar K Desai (MK)

Internal Medicine, Hamilton Medical Center, Medical College of Georgia/Augusta University, Augusta, USA.

Dharmeshkumar V Moradiya (DV)

Internal Medicine, St John of God Murdoch Hospital, Murdoch, AUS.

Hiteshkumar Devani (H)

Dental Medicine, University of Pittsburgh School of Dental Medicine, Pittsburgh, USA.

Apurwa Karki (A)

Critical Care, Guthrie Cortland Medical Center, Cortland, USA.

Classifications MeSH