Biliary Strictures and Cholangiocarcinoma - Untangling a Diagnostic Conundrum.
ERCP (Endoscopic Retrograde Cholangiopancreatography)
biliary strictures
biomarkers
cholangiocarcinoma
early detection
primary sclerosing cholangitis (PSC)
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2021
2021
Historique:
received:
23
04
2021
accepted:
15
09
2021
entrez:
18
10
2021
pubmed:
19
10
2021
medline:
19
10
2021
Statut:
epublish
Résumé
Cholangiocarcinoma is an uncommon and highly aggressive biliary tract malignancy with few manifestations until late disease stages. Diagnosis is currently achieved through a combination of clinical, biochemical, radiological and histological techniques. A number of reported cancer biomarkers have the potential to be incorporated into diagnostic pathways, but all lack sufficient sensitivity and specificity limiting their possible use in screening and early diagnosis. The limitations of standard serum markers such as CA19-9, CA125 and CEA have driven researchers to identify multiple novel biomarkers, yet their clinical translation has been slow with a general requirement for further validation in larger patient cohorts. We review recent advances in the diagnostic pathway for suspected CCA as well as emerging diagnostic biomarkers for early detection, with a particular focus on non-invasive approaches.
Identifiants
pubmed: 34660269
doi: 10.3389/fonc.2021.699401
pmc: PMC8515053
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
699401Subventions
Organisme : Pancreatic Cancer UK
ID : RG2014_01_PERERIA
Pays : United Kingdom
Informations de copyright
Copyright © 2021 Ney, Garcia-Sampedro, Goodchild, Acedo, Fusai and Pereira.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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