A Key Silencing Histone Mark on Chromatin Is Lost When Colorectal Adenocarcinoma Cells Are Depleted of Methionine by Methionine γ-Lyase.
cancer therapy
enzyme-based therapy
histone methylation
mass spectrometry
methionine
Journal
Frontiers in molecular biosciences
ISSN: 2296-889X
Titre abrégé: Front Mol Biosci
Pays: Switzerland
ID NLM: 101653173
Informations de publication
Date de publication:
2021
2021
Historique:
received:
02
07
2021
accepted:
02
09
2021
entrez:
18
10
2021
pubmed:
19
10
2021
medline:
19
10
2021
Statut:
epublish
Résumé
Methionine is an essential amino acid used, beyond protein synthesis, for polyamine formation and DNA/RNA/protein methylation. Cancer cells require particularly high methionine supply for their homeostasis. A successful approach for decreasing methionine concentration is based on the systemic delivery of methionine γ-lyase (MGL), with
Identifiants
pubmed: 34660696
doi: 10.3389/fmolb.2021.735303
pii: 735303
pmc: PMC8517235
doi:
Types de publication
Journal Article
Langues
eng
Pagination
735303Subventions
Organisme : NCI NIH HHS
ID : P01 CA196539
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI118891
Pays : United States
Informations de copyright
Copyright © 2021 Raboni, Montalbano, Stransky, Garcia, Buschini, Bettati, Sidoli and Mozzarelli.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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