Naturally Occurring Genetic Variants in the Oxytocin Receptor Alter Receptor Signaling Profiles.
Journal
ACS pharmacology & translational science
ISSN: 2575-9108
Titre abrégé: ACS Pharmacol Transl Sci
Pays: United States
ID NLM: 101721411
Informations de publication
Date de publication:
08 Oct 2021
08 Oct 2021
Historique:
received:
30
03
2021
entrez:
18
10
2021
pubmed:
19
10
2021
medline:
19
10
2021
Statut:
epublish
Résumé
The hormone oxytocin is commonly administered during childbirth to initiate and strengthen uterine contractions and prevent postpartum hemorrhage. However, patients have wide variation in the oxytocin dose required for a clinical response. To begin to uncover the mechanisms underlying this variability, we screened the 11 most prevalent missense genetic variants in the oxytocin receptor (
Identifiants
pubmed: 34661073
doi: 10.1021/acsptsci.1c00095
pmc: PMC8506602
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1543-1555Subventions
Organisme : NICHD NIH HHS
ID : F30 HD097925
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD088097
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD096737
Pays : United States
Organisme : NCATS NIH HHS
ID : TL1 TR002344
Pays : United States
Informations de copyright
© 2021 The Authors. Published by American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
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