A Novel Antagonist Peptide Reveals a Physiological Role of Insulin-Like Peptide 5 in Control of Colorectal Function.


Journal

ACS pharmacology & translational science
ISSN: 2575-9108
Titre abrégé: ACS Pharmacol Transl Sci
Pays: United States
ID NLM: 101721411

Informations de publication

Date de publication:
08 Oct 2021
Historique:
received: 06 07 2021
entrez: 18 10 2021
pubmed: 19 10 2021
medline: 19 10 2021
Statut: epublish

Résumé

Insulin-like peptide 5 (INSL5), the natural ligand for the relaxin family peptide receptor 4 (RXFP4), is a gut hormone that is exclusively produced by colonic L-cells. We have recently developed an analogue of INSL5, INSL5-A13, that acts as an RXFP4 agonist

Identifiants

pubmed: 34661082
doi: 10.1021/acsptsci.1c00171
pmc: PMC8506612
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1665-1674

Informations de copyright

© 2021 American Chemical Society.

Déclaration de conflit d'intérêts

The authors declare no competing financial interest.

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Auteurs

Ruslan V Pustovit (RV)

The Florey Institute of Neuroscience and Mental Health; Department of Anatomy and Physiology; School of Biosciences, Melbourne Mass Spectrometry and Proteomics Facility, Bio21 Institute; Department of Biochemistry and Pharmacology; School of Chemistry; The University of Melbourne, Parkville, Victoria 3052, Australia.

Xiaozhou Zhang (X)

The Florey Institute of Neuroscience and Mental Health; Department of Anatomy and Physiology; School of Biosciences, Melbourne Mass Spectrometry and Proteomics Facility, Bio21 Institute; Department of Biochemistry and Pharmacology; School of Chemistry; The University of Melbourne, Parkville, Victoria 3052, Australia.

Jamie Jm Liew (JJ)

The Florey Institute of Neuroscience and Mental Health; Department of Anatomy and Physiology; School of Biosciences, Melbourne Mass Spectrometry and Proteomics Facility, Bio21 Institute; Department of Biochemistry and Pharmacology; School of Chemistry; The University of Melbourne, Parkville, Victoria 3052, Australia.

Praveen Praveen (P)

The Florey Institute of Neuroscience and Mental Health; Department of Anatomy and Physiology; School of Biosciences, Melbourne Mass Spectrometry and Proteomics Facility, Bio21 Institute; Department of Biochemistry and Pharmacology; School of Chemistry; The University of Melbourne, Parkville, Victoria 3052, Australia.

Mengjie Liu (M)

The Florey Institute of Neuroscience and Mental Health; Department of Anatomy and Physiology; School of Biosciences, Melbourne Mass Spectrometry and Proteomics Facility, Bio21 Institute; Department of Biochemistry and Pharmacology; School of Chemistry; The University of Melbourne, Parkville, Victoria 3052, Australia.

Ada Koo (A)

The Florey Institute of Neuroscience and Mental Health; Department of Anatomy and Physiology; School of Biosciences, Melbourne Mass Spectrometry and Proteomics Facility, Bio21 Institute; Department of Biochemistry and Pharmacology; School of Chemistry; The University of Melbourne, Parkville, Victoria 3052, Australia.

Lalita Oparija-Rogenmozere (L)

The Florey Institute of Neuroscience and Mental Health; Department of Anatomy and Physiology; School of Biosciences, Melbourne Mass Spectrometry and Proteomics Facility, Bio21 Institute; Department of Biochemistry and Pharmacology; School of Chemistry; The University of Melbourne, Parkville, Victoria 3052, Australia.

Qinghao Ou (Q)

The Florey Institute of Neuroscience and Mental Health; Department of Anatomy and Physiology; School of Biosciences, Melbourne Mass Spectrometry and Proteomics Facility, Bio21 Institute; Department of Biochemistry and Pharmacology; School of Chemistry; The University of Melbourne, Parkville, Victoria 3052, Australia.

Martina Kocan (M)

The Florey Institute of Neuroscience and Mental Health; Department of Anatomy and Physiology; School of Biosciences, Melbourne Mass Spectrometry and Proteomics Facility, Bio21 Institute; Department of Biochemistry and Pharmacology; School of Chemistry; The University of Melbourne, Parkville, Victoria 3052, Australia.

Shuai Nie (S)

The Florey Institute of Neuroscience and Mental Health; Department of Anatomy and Physiology; School of Biosciences, Melbourne Mass Spectrometry and Proteomics Facility, Bio21 Institute; Department of Biochemistry and Pharmacology; School of Chemistry; The University of Melbourne, Parkville, Victoria 3052, Australia.

Ross Ad Bathgate (RA)

The Florey Institute of Neuroscience and Mental Health; Department of Anatomy and Physiology; School of Biosciences, Melbourne Mass Spectrometry and Proteomics Facility, Bio21 Institute; Department of Biochemistry and Pharmacology; School of Chemistry; The University of Melbourne, Parkville, Victoria 3052, Australia.

John B Furness (JB)

The Florey Institute of Neuroscience and Mental Health; Department of Anatomy and Physiology; School of Biosciences, Melbourne Mass Spectrometry and Proteomics Facility, Bio21 Institute; Department of Biochemistry and Pharmacology; School of Chemistry; The University of Melbourne, Parkville, Victoria 3052, Australia.

Mohammed Akhter Hossain (MA)

The Florey Institute of Neuroscience and Mental Health; Department of Anatomy and Physiology; School of Biosciences, Melbourne Mass Spectrometry and Proteomics Facility, Bio21 Institute; Department of Biochemistry and Pharmacology; School of Chemistry; The University of Melbourne, Parkville, Victoria 3052, Australia.

Classifications MeSH