Sequence complementarity between human noncoding RNAs and SARS-CoV-2 genes: What are the implications for human health?
Bioinformatics
COVID-19
Epigenetics
Long non-coding RNA
SARS-CoV-2
Small nuclear RNA
Journal
Biochimica et biophysica acta. Molecular basis of disease
ISSN: 1879-260X
Titre abrégé: Biochim Biophys Acta Mol Basis Dis
Pays: Netherlands
ID NLM: 101731730
Informations de publication
Date de publication:
01 02 2022
01 02 2022
Historique:
received:
24
05
2021
revised:
17
09
2021
accepted:
09
10
2021
pubmed:
19
10
2021
medline:
11
1
2022
entrez:
18
10
2021
Statut:
ppublish
Résumé
To investigate in silico the presence of nucleotide sequence complementarity between the RNA genome of Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2) and human non-coding (nc)RNA genes. The FASTA sequence (NC_045512.2) of each of the 11 SARS-CoV-2 isolate Wuhan-Hu-1 genes was retrieved from NCBI.nlm.nih.gov/gene and the Ensembl.org library interrogated for any base-pair match with human ncRNA genes. SARS-CoV-2 gene-matched human ncRNAs were screened for functional activity using bioinformatic analysis. Finally, associations between identified ncRNAs and human diseases were searched in GWAS databases. A total of 252 matches were found between the nucleotide sequence of SARS-CoV-2 genes and human ncRNAs. With the exception of two small nuclear RNAs, all of them were long non-coding (lnc)RNAs expressed mainly in testis and central nervous system under physiological conditions. The percentage of alignment ranged from 91.30% to 100% with a mean nucleotide alignment length of 17.5 ± 2.4. Thirty-three (13.09%) of them contained predicted R-loop forming sequences, but none of these intersected the complementary sequences of SARS-CoV-2. However, in 31 cases matches fell on ncRNA regulatory sites, whose adjacent coding genes are mostly involved in cancer, immunological and neurological pathways. Similarly, several polymorphic variants of detected non-coding genes have been associated with neuropsychiatric and proliferative disorders. This pivotal in silico study shows that SARS-CoV-2 genes have Watson-Crick nucleotide complementarity to human ncRNA sequences, potentially disrupting ncRNA epigenetic control of target genes. It remains to be elucidated whether this could result in the development of human disease in the long term.
Identifiants
pubmed: 34662705
pii: S0925-4439(21)00224-6
doi: 10.1016/j.bbadis.2021.166291
pmc: PMC8518135
pii:
doi:
Substances chimiques
RNA, Long Noncoding
0
RNA, Untranslated
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
166291Informations de copyright
Copyright © 2021. Published by Elsevier B.V.
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