Context value updating and multidimensional neuronal encoding in the retrosplenial cortex.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
18 10 2021
18 10 2021
Historique:
received:
10
11
2019
accepted:
24
09
2021
entrez:
19
10
2021
pubmed:
20
10
2021
medline:
18
11
2021
Statut:
epublish
Résumé
The retrosplenial cortex (RSC) has diverse functional inputs and is engaged by various sensory, spatial, and associative learning tasks. We examine how multiple functional aspects are integrated on the single-cell level in the RSC and how the encoding of task-related parameters changes across learning. Using a visuospatial context discrimination paradigm and two-photon calcium imaging in behaving mice, a large proportion of dysgranular RSC neurons was found to encode multiple task-related dimensions while forming context-value associations across learning. During reversal learning requiring increased cognitive flexibility, we revealed an increased proportion of multidimensional encoding neurons that showed higher decoding accuracy for behaviorally relevant context-value associations. Chemogenetic inactivation of RSC led to decreased behavioral context discrimination during learning phases in which context-value associations were formed, while recall of previously formed associations remained intact. RSC inactivation resulted in a persistent positive behavioral bias in valuing contexts, indicating a role for the RSC in context-value updating.
Identifiants
pubmed: 34663792
doi: 10.1038/s41467-021-26301-z
pii: 10.1038/s41467-021-26301-z
pmc: PMC8523535
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6045Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2021. The Author(s).
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