Identification of Type II Toxin-Antitoxin Loci in Levilactobacillus brevis.
In silico analysis
Levilactobacillus brevis
Type II toxin-antitoxin loci
Journal
Interdisciplinary sciences, computational life sciences
ISSN: 1867-1462
Titre abrégé: Interdiscip Sci
Pays: Germany
ID NLM: 101515919
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
13
07
2021
accepted:
05
10
2021
revised:
30
09
2021
pubmed:
20
10
2021
medline:
11
3
2022
entrez:
19
10
2021
Statut:
ppublish
Résumé
Levilactobacillus brevis are present in various environments, such as beer, fermented foods, silage, and animal host. Like other lactic acid bacteria, L. brevis might adopt the viable but nonculturable (VBNC) state under unfavorable conditions. The toxin-antitoxin (TA) system, known to regulate cell growth in response to environmental stresses, is found to control the dynamic of the VBNC state. Here, we investigate the type II TA locus prevalence and compare the TA diversity in L. brevis genomes. Using the TAfinder software, we identified a total of 273 putative type II TA loci in 110 replicons of 21 completely sequenced genomes. Genome size does not appear to correlate with the amount of putative type II TA in L. brevis. Besides, type II TA loci are distributed differently among the chromosomes and plasmids. The most prevalent toxin domain is MazF-like in the chromosomes, and RelE/RelE-like in the plasmids; while for antitoxin, Xre-like and Phd-like domains are the most common in the chromosomes and plasmids, respectively. We also observed a unique GNAT-like/ArsR-like TA pair that presents only in the L. brevis chromosome. Detection of 273 putative type II TA loci in 21 complete genomes of Levilactobacillus brevis.
Identifiants
pubmed: 34664198
doi: 10.1007/s12539-021-00486-9
pii: 10.1007/s12539-021-00486-9
doi:
Substances chimiques
Antitoxins
0
Bacterial Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
80-88Subventions
Organisme : national key research and development program of china
ID : 2017YFC1600105
Informations de copyright
© 2021. International Association of Scientists in the Interdisciplinary Areas.
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