Aplysia Neurons as a Model of Alzheimer's Disease: Shared Genes and Differential Expression.
Beta-amyloid
Invertebrate model
Neuroinflammation
Tau
Journal
Journal of molecular neuroscience : MN
ISSN: 1559-1166
Titre abrégé: J Mol Neurosci
Pays: United States
ID NLM: 9002991
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
05
08
2021
accepted:
18
09
2021
pubmed:
20
10
2021
medline:
5
4
2022
entrez:
19
10
2021
Statut:
ppublish
Résumé
Although Alzheimer's disease (AD) is the most common form of dementia in the United States, development of therapeutics has proven difficult. Invertebrate alternatives to current mammalian AD models have been successfully employed to study the etiology of the molecular hallmarks of AD. The marine snail Aplysia californica offers a unique and underutilized system in which to study the physiological, behavioral, and molecular impacts of AD. Mapping of the Aplysia proteome to humans and cross-referencing with two databases of genes of interest in AD research identified 898 potential orthologs of interest in Aplysia. Included among these orthologs were alpha, beta and gamma secretases, amyloid-beta, and tau. Comparison of age-associated differential expression in Aplysia sensory neurons with that of late-onset AD in the frontal lobe identified 59 ortholog with concordant differential expression across data sets. The 21 concordantly upregulated genes suggested increased cellular stress and protein dyshomeostasis. The 47 concordantly downregulated genes included important components of diverse neuronal processes, including energy metabolism, mitochondrial homeostasis, synaptic signaling, Ca
Identifiants
pubmed: 34664226
doi: 10.1007/s12031-021-01918-3
pii: 10.1007/s12031-021-01918-3
pmc: PMC8840921
doi:
Substances chimiques
Amyloid beta-Peptides
0
tau Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
287-302Subventions
Organisme : NIH HHS
ID : P40 OD010952
Pays : United States
Organisme : national institutes of health (nih)
ID : P40OD010952
Informations de copyright
© 2021. The Author(s).
Références
Gene. 2016 Feb 15;577(2):101-8
pubmed: 26687711
J Biol Chem. 2011 Feb 18;286(7):5744-55
pubmed: 21148305
J Neurosci. 1998 Nov 15;18(22):9269-81
pubmed: 9801366
Oncogene. 2020 Apr;39(16):3381-3395
pubmed: 32103170
Curr Biol. 2012 Sep 11;22(17):R705-11
pubmed: 22975001
Alzheimers Dement. 2018 Apr;14(4):535-562
pubmed: 29653606
Alzheimers Res Ther. 2012 Dec 06;4(6):47
pubmed: 23217212
Nat Rev Neurosci. 2011 May;12(5):284-96
pubmed: 21448224
Diabetes. 2014 Jan;63(1):152-61
pubmed: 23990363
Nat Cell Biol. 2007 Dec;9(12):1370-80
pubmed: 17994011
Behav Neural Biol. 1983 May;38(1):70-81
pubmed: 6626101
Neuron. 2003 Oct 9;40(2):331-46
pubmed: 14556712
Behav Biol. 1974 Jan;10(1):1-26
pubmed: 4815142
BMC Genomics. 2016 Feb 27;17:146
pubmed: 26921237
Cell. 2013 Jun 6;153(6):1194-217
pubmed: 23746838
Front Aging Neurosci. 2010 May 19;2:
pubmed: 20725513
Front Med (Lausanne). 2018 Mar 12;5:61
pubmed: 29662881
Curr Pharm Des. 2021;27(3):402-414
pubmed: 33213314
Eur J Pharmacol. 2017 Nov 15;815:312-323
pubmed: 28943103
Int J Biochem Cell Biol. 1998 May;30(5):573-7
pubmed: 9693958
Front Aging Neurosci. 2015 Sep 03;7:173
pubmed: 26388769
Neurobiol Aging. 1992 Mar-Apr;13(2):217-25
pubmed: 1522939
J Biol Chem. 2000 Nov 3;275(44):34433-41
pubmed: 10950954
Am J Pathol. 2009 Apr;174(4):1241-51
pubmed: 19264902
Alzheimers Res Ther. 2017 Sep 12;9(1):71
pubmed: 28899416
Neurobiol Aging. 2015 May;36(5):1903-13
pubmed: 25726361
Biomed Pharmacother. 2021 Jun;138:111405
pubmed: 33756153
J Neurosci. 1998 Aug 1;18(15):5988-98
pubmed: 9671684
J Biol Chem. 2001 May 18;276(20):17301-6
pubmed: 11278679
Neurobiol Aging. 2006 Nov;27(11):1564-76
pubmed: 16271804
Proc Natl Acad Sci U S A. 1982 Sep;79(18):5713-7
pubmed: 6957886
Methods Mol Biol. 2013;1048:323-52
pubmed: 23929113
Proc Natl Acad Sci U S A. 2017 May 16;114(20):E3993-E4001
pubmed: 28461486
J Alzheimers Dis. 2017;58(2):303-322
pubmed: 28409746
Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1217-22
pubmed: 14745023
F1000Res. 2018 Jul 31;7:
pubmed: 30135715
Cell Calcium. 1998 Feb-Mar;23(2-3):131-4
pubmed: 9601608
Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14342-7
pubmed: 17766440
Science. 2003 May 2;300(5620):808-12
pubmed: 12730604
Mol Neurodegener. 2013 Nov 22;8:35
pubmed: 24267573
Pharmacol Res. 2018 Mar;129:188-193
pubmed: 29183769
Biol Bull. 2006 Jun;210(3):271-9
pubmed: 16801500
J Biol Chem. 2004 Nov 19;279(47):49420-9
pubmed: 15339911
EMBO Rep. 2003 Nov;4(11):1089-95
pubmed: 14555962
Trends Biochem Sci. 2010 Apr;35(4):228-35
pubmed: 20036556
RNA. 2013 Aug;19(8):1019-37
pubmed: 23861535
Exp Neurol. 2015 Dec;274(Pt A):58-71
pubmed: 26024860
J Neurochem. 2007 Dec;103(6):2665-78
pubmed: 17953666
Science. 2020 Apr 24;368(6489):
pubmed: 32327570
BMC Genomics. 2018 Jul 11;19(1):529
pubmed: 29996779
Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16072-7
pubmed: 16247020
Int J Mol Sci. 2019 Jul 04;20(13):
pubmed: 31277513
Exp Neurol. 2009 Jun;217(2):242-51
pubmed: 19268666
Cell. 2006 Aug 25;126(4):775-88
pubmed: 16923396
J Virol. 2006 Jun;80(11):5301-7
pubmed: 16699010
Aging Cell. 2017 Aug;16(4):615-623
pubmed: 28436203
EMBO Rep. 2016 Oct;17(10):1374-1395
pubmed: 27629041
Invert Neurosci. 2011 Dec;11(2):73-83
pubmed: 22068627
Science. 1983 Jan 28;219(4583):397-400
pubmed: 6681571
J Mol Signal. 2008 Sep 12;3:15
pubmed: 18789159
Prog Neurobiol. 2020 Nov;194:101801
pubmed: 32428558
Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13217-21
pubmed: 12244210
Exp Neurol. 2001 Apr;168(2):250-8
pubmed: 11259113
Arterioscler Thromb Vasc Biol. 2004 Oct;24(10):1830-5
pubmed: 15308555
J Cell Physiol. 2019 May;234(5):5379-5389
pubmed: 30350856
Bioessays. 2006 Aug;28(8):822-33
pubmed: 16927307
Transl Stroke Res. 2020 Jun;11(3):418-432
pubmed: 31473978
Annu Rev Neurosci. 1998;21:127-48
pubmed: 9530494
J Clin Invest. 2018 Aug 31;128(9):3662-3670
pubmed: 30059016
Cell. 1993 Mar 12;72(5):729-39
pubmed: 8453667
Brain Pathol. 2016 Sep;26(5):593-605
pubmed: 26512942
Mol Genet Metab. 2017 Dec;122(4):145-152
pubmed: 29033250
CNS Neurol Disord Drug Targets. 2019;18(1):3-10
pubmed: 28782486
Philos Trans R Soc Lond B Biol Sci. 1999 Sep 29;354(1389):1601-9
pubmed: 10582246
Front Aging Neurosci. 2016 Feb 12;8:24
pubmed: 26903863
Cell Death Differ. 2015 Apr;22(4):612-25
pubmed: 25257176
Cell. 2006 Dec 29;127(7):1453-67
pubmed: 17190607
J Cell Sci. 2015 Aug 1;128(15):2781-94
pubmed: 26101353
Front Aging Neurosci. 2014 May 09;6:84
pubmed: 24847260
Int J Mol Sci. 2019 Jan 18;20(2):
pubmed: 30669311
Prog Neurobiol. 2010 Aug;91(4):313-48
pubmed: 20438797
FASEB J. 2019 Feb;33(2):1540-1553
pubmed: 30222078
J Biol Chem. 2017 Jun 16;292(24):10061-10067
pubmed: 28461337
Neural Regen Res. 2018 Apr;13(4):616-623
pubmed: 29722304
Science. 1970 Mar 27;167(3926):1745-8
pubmed: 5416543
PLoS One. 2015 May 13;10(5):e0127056
pubmed: 25970633
Inflamm Regen. 2017 Mar 8;37:6
pubmed: 29259705
J Neurochem. 2016 Apr;137(1):12-25
pubmed: 26756400
Cell Calcium. 2018 Jan;69:62-72
pubmed: 28515000
J Biol Chem. 2017 Dec 29;292(52):21466-21480
pubmed: 29109144
Nat Commun. 2020 May 1;11(1):2146
pubmed: 32358564
Neuroreport. 1991 Aug;2(8):465-8
pubmed: 1912481
Neuroscience. 2019 Jun 1;408:430-447
pubmed: 30943435
Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8443-8
pubmed: 8710890
Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3773-81
pubmed: 27298345
Mech Ageing Dev. 1999 Nov 2;111(1):39-47
pubmed: 10576606
Life Sci. 1996;59(5-6):429-34
pubmed: 8761331
Mol Cell Biol. 1996 Apr;16(4):1342-8
pubmed: 8657107
J Neurosci. 2003 Oct 22;23(29):9585-94
pubmed: 14573538
Neuropathol Appl Neurobiol. 2002 Dec;28(6):441-51
pubmed: 12445160
J Biol Chem. 2003 Jul 18;278(29):27053-8
pubmed: 12736248
Nat Neurosci. 2005 Aug;8(8):1051-8
pubmed: 16025111
Aging (Albany NY). 2017 Mar 26;9(3):627-649
pubmed: 28351997
J Neurosci. 2005 Jul 20;25(29):6887-97
pubmed: 16033898
J Neurobiol. 1981 Sep;12(5):469-78
pubmed: 7276930
Nutrients. 2019 Feb 27;11(3):
pubmed: 30818813
Nat Rev Neurosci. 2008 Jul;9(7):532-44
pubmed: 18568014
Neuron. 1997 Jun;18(6):899-912
pubmed: 9208858
Front Mol Neurosci. 2020 Sep 18;13:556175
pubmed: 33071754
Proc Biol Sci. 1994 Mar 22;255(1344):215-21
pubmed: 7912832
Antioxid Redox Signal. 2014 Apr 1;20(10):1533-47
pubmed: 24328503
Antioxid Redox Signal. 2011 Apr 1;14(7):1261-73
pubmed: 20626318
Neural Regen Res. 2015 Apr;10(4):559-61
pubmed: 26170813
Mol Cell Biol. 2004 Dec;24(23):10161-8
pubmed: 15542827
Cell. 1996 Dec 27;87(7):1203-14
pubmed: 8980227
Neuron. 2001 Nov 8;32(3):463-75
pubmed: 11709157
Learn Mem. 2006 Nov-Dec;13(6):669-80
pubmed: 17142299
J Biol Chem. 2014 Jan 17;289(3):1629-38
pubmed: 24280221
Pharmaceuticals (Basel). 2018 Jan 29;11(1):
pubmed: 29382156
BMC Genomics. 2013 Dec 14;14:880
pubmed: 24330282
J Neurosci. 2021 Feb 3;41(5):947-959
pubmed: 33298536
Neurosci Lett. 1996 Aug 9;213(3):213-5
pubmed: 8873152
Neurobiol Dis. 2011 Jul;43(1):163-75
pubmed: 21406229
Biochem J. 2005 Sep 1;390(Pt 2):501-11
pubmed: 15853766
Nat Commun. 2013;4:2033
pubmed: 23783758
Neuroreport. 2002 Dec 20;13(18):2429-32
pubmed: 12499843
Front Aging Neurosci. 2020 Sep 15;12:573764
pubmed: 33101008
J Alzheimers Dis. 2009;16(2):409-19
pubmed: 19221430
Science. 1993 Mar 26;259(5103):1912-5
pubmed: 8096091
Science. 2019 Jul 5;365(6448):
pubmed: 31273097
J Neurosci Res. 2002 Nov 1;70(3):462-73
pubmed: 12391607
Oncogene. 2009 Feb 12;28(6):910-20
pubmed: 19029953
Biology (Basel). 2019 Jun 17;8(2):
pubmed: 31213034
Nat Commun. 2019 Aug 29;10(1):3885
pubmed: 31467276
J Biol Chem. 2017 May 12;292(19):7904-7920
pubmed: 28302725
J Biol Chem. 2004 Apr 23;279(17):17148-57
pubmed: 14960583
Mol Cell Biol. 2004 Nov;24(21):9658-67
pubmed: 15485931
Hum Genet. 2020 Mar;139(3):277-290
pubmed: 31144030
Genes Dev. 2004 Dec 1;18(23):2879-92
pubmed: 15545626
Cell. 1990 May 18;61(4):709-21
pubmed: 2111733
Brain Res. 1999 Apr 10;824(2):300-3
pubmed: 10196463
Acta Neuropathol. 2005 Aug;110(2):165-72
pubmed: 15973543
J Neurosci. 2009 Dec 9;29(49):15542-50
pubmed: 20007478
Nat Rev Neurosci. 2012 Jan 05;13(2):77-93
pubmed: 22218207
Oncotarget. 2016 Jan 19;7(3):3128-43
pubmed: 26657730
Curr Biol. 2011 Jan 25;21(2):R60-1
pubmed: 21256433
Cell Metab. 2019 Oct 1;30(4):630-655
pubmed: 31577933
Dongwuxue Yanjiu. 2014 Sep;35(5):389-97
pubmed: 25297078
J Biol Chem. 1999 Aug 13;274(33):23558-64
pubmed: 10438536
PLoS One. 2019 May 23;14(5):e0217300
pubmed: 31120976
Behav Brain Res. 1996 May;77(1-2):115-24
pubmed: 8762162
J Neurochem. 2017 Nov;143(4):418-431
pubmed: 28397282
EMBO Rep. 2007 May;8(5):483-9
pubmed: 17380188
Front Pharmacol. 2014 Oct 24;5:227
pubmed: 25386142
Nat Genet. 2007 Jan;39(1):17-23
pubmed: 17192785
Oxid Med Cell Longev. 2017;2017:6473506
pubmed: 29204248
Mol Cell Biol. 2006 Jul;26(13):4863-71
pubmed: 16782875
Dev Comp Immunol. 2017 Nov;76:1-8
pubmed: 28506725
Alzheimers Res Ther. 2017 Apr 27;9(1):29
pubmed: 28446202
Front Immunol. 2017 Dec 11;8:1805
pubmed: 29312321
Front Genet. 2014 Sep 05;5:279
pubmed: 25250042
Genes Brain Behav. 2005 Apr;4(3):147-56
pubmed: 15810903
Acta Neuropathol. 2010 Aug;120(2):209-22
pubmed: 20422200
Sci Rep. 2015 Jul 23;5:12393
pubmed: 26202100
Sci Rep. 2015 Mar 03;5:8693
pubmed: 25732911
Neurobiol Aging. 2003 Dec;24(8):1029-46
pubmed: 14643375
Ecotoxicol Environ Saf. 2019 Apr 15;170:673-681
pubmed: 30580161
Korean J Physiol Pharmacol. 2018 May;22(3):343-348
pubmed: 29719456
J Intern Med. 2014 Mar;275(3):251-83
pubmed: 24605808
Cells. 2021 Feb 16;10(2):
pubmed: 33669308
BMC Bioinformatics. 2009 Dec 15;10:421
pubmed: 20003500
J Neurobiol. 1981 Sep;12(5):455-68
pubmed: 7276929
Hum Genet. 2019 Dec;138(11-12):1247-1257
pubmed: 31538237
Free Radic Biol Med. 2016 Nov;100:108-122
pubmed: 27154981
Virology. 2010 Aug 1;403(2):173-80
pubmed: 20471052
Cell Struct Funct. 2012;37(2):141-54
pubmed: 22971977
Mol Cell Biol. 2002 Apr;22(7):2283-93
pubmed: 11884613
Biochim Biophys Acta Mol Cell Res. 2018 Nov;1865(11 Pt B):1745-1760
pubmed: 30059692
mBio. 2015 Apr 14;6(2):
pubmed: 25873381
Proc Natl Acad Sci U S A. 1984 Jul;81(13):4232-6
pubmed: 6330753