Studying the Tumor Microenvironment in Zebrafish.
Adipocytes
Cancer
Compound testing
Extracellular vesicles
Fibroblasts
In vivo
Innate immune cells
Live imaging
Macrophages
Metastasis
Microglia
Neo-angiogenesis
Neutrophils
Tumor microenvironment
Tumor proliferation
Zebrafish
Journal
Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
19
10
2021
pubmed:
20
10
2021
medline:
21
10
2021
Statut:
ppublish
Résumé
The tumor microenvironment significantly contributes to tumor initiation, progression, neo-angiogenesis, and metastasis, and a better understanding of the role of the different cellular players would facilitate the development of novel therapeutic strategies for cancer treatment. Towards this goal, intravital imaging is a powerful method to unravel interaction partners of tumor cells. Among vertebrate model organisms, zebrafish is uniquely suited for in vivo imaging studies. In recent years zebrafish has also become a valuable model in cancer research. In this chapter, we will summarize, how zebrafish has been used to characterize cells of the tumor microenvironment. We will cover both genetically engineered cancer models and xenograft models in zebrafish. The majority of work has been done on the role of innate immune cells and their role during tumor initiation and metastasis, but we will also cover studies focusing on adipocytes, fibroblasts, and endothelial cells. Taken together, we will highlight the versatile use of the zebrafish model for in vivo tumor microenvironment studies.
Identifiants
pubmed: 34664234
doi: 10.1007/978-3-030-73119-9_4
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
69-92Informations de copyright
© 2021. The Author(s), under exclusive license to Springer Nature Switzerland AG.
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