Life expectancy with and without dementia in persons with mild cognitive impairment in the community.
dementia
education
life expectancy
mild cognitive impairment
multistate model
Journal
Journal of the American Geriatrics Society
ISSN: 1532-5415
Titre abrégé: J Am Geriatr Soc
Pays: United States
ID NLM: 7503062
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
revised:
13
09
2021
received:
04
05
2021
accepted:
24
09
2021
pubmed:
20
10
2021
medline:
3
3
2022
entrez:
19
10
2021
Statut:
ppublish
Résumé
Various clinical studies have provided estimates of life expectancy of patients with mild cognitive impairment (MCI) from outpatient clinics, but whether these apply to community-dwelling individuals at home or in primary care is uncertain. Within the population-based Rotterdam Study, we studied life expectancy with and without dementia in 648 community-dwelling persons with MCI and 6410 without MCI. Participants aged 60 years and older were assessed for MCI at baseline (2002-2014) and subsequently followed for the onset of dementia and death. We used multistate life tables to determine age-specific life expectancy with and without dementia by sex, educational attainment, and MCI subtype. Total life expectancy for MCI ranged from 21.4 years (95% CI: 19.0-23.6) at age 60 to 2.6 years (1.6-3.6) at age 95. With advancing age, an increasing proportion of these years was lived with dementia (2.9 years [1.8-4.0] at age 60; 1.2 [0.2-2.2] at age 95). Women and higher educated individuals lived longer and lived more years with dementia. No differences in total life expectancy were observed by MCI subtype, although individuals with amnestic MCI lived a larger proportion of those years with dementia. Prognosis of MCI, in terms of life years lived with and without dementia, is more favorable in the general population than described in prior clinical observations, due likely to a substantial proportion of individuals with MCI in the clinic not seeking medical attention in an earlier stage.
Sections du résumé
BACKGROUND
Various clinical studies have provided estimates of life expectancy of patients with mild cognitive impairment (MCI) from outpatient clinics, but whether these apply to community-dwelling individuals at home or in primary care is uncertain.
METHODS
Within the population-based Rotterdam Study, we studied life expectancy with and without dementia in 648 community-dwelling persons with MCI and 6410 without MCI. Participants aged 60 years and older were assessed for MCI at baseline (2002-2014) and subsequently followed for the onset of dementia and death. We used multistate life tables to determine age-specific life expectancy with and without dementia by sex, educational attainment, and MCI subtype.
RESULTS
Total life expectancy for MCI ranged from 21.4 years (95% CI: 19.0-23.6) at age 60 to 2.6 years (1.6-3.6) at age 95. With advancing age, an increasing proportion of these years was lived with dementia (2.9 years [1.8-4.0] at age 60; 1.2 [0.2-2.2] at age 95). Women and higher educated individuals lived longer and lived more years with dementia. No differences in total life expectancy were observed by MCI subtype, although individuals with amnestic MCI lived a larger proportion of those years with dementia.
CONCLUSIONS
Prognosis of MCI, in terms of life years lived with and without dementia, is more favorable in the general population than described in prior clinical observations, due likely to a substantial proportion of individuals with MCI in the clinic not seeking medical attention in an earlier stage.
Identifiants
pubmed: 34664261
doi: 10.1111/jgs.17520
pmc: PMC9298312
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
481-489Informations de copyright
© 2021 The Authors. Journal of the American Geriatrics Society published by Wiley Periodicals LLC on behalf of The American Geriatrics Society.
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