Antiproliferative Wnt inhibitor wogonin prevents eryptosis following ionophoric challenge, hyperosmotic shock, oxidative stress, and metabolic deprivation.
calcium
chemotherapy
eryptosis
hemolysis
phosphatidylserine
wogonin
Journal
Journal of food biochemistry
ISSN: 1745-4514
Titre abrégé: J Food Biochem
Pays: United States
ID NLM: 7706045
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
revised:
23
09
2021
received:
19
08
2021
accepted:
10
10
2021
pubmed:
20
10
2021
medline:
15
12
2021
entrez:
19
10
2021
Statut:
ppublish
Résumé
Anemia is a common complication of chemotherapy and may arise due to premature or suicidal death of red blood cells (RBCs). Prevention of RBC death thus lends itself as a promising strategy to counteract anemia. Wogonin (WGN; 5,7-dihydroxy-8-methoxyflavone) is a Wnt inhibitor derived from Scutellaria baicalensis plant with potent cytotoxic and antitumor potential. However, the nature of interaction of WGN with human RBCs is unknown. RBCs from healthy participants were exposed to different hemolytic and eryptotic stimuli for 24 or 48 hr at 37°C in the presence and absence of 100 μM WGN. Calcium overload was induced by 2 μM ionomycin, hyperosmotic shock with excessive sucrose, oxidative stress by 2-phenethyl isothiocyanate (PEITC), and metabolic deprivation by exclusion of glucose. Hemolysis was estimated from extracellular hemoglobin, phosphatidylserine (PS) exposure by Annexin V-FITC, intracellular calcium by Fluo4/AM, and oxidative stress by 2',7'-dichlorodihydrofluorescein diacetate (H
Substances chimiques
Flavanones
0
Ionophores
0
Pharmaceutical Preparations
0
wogonin
POK93PO28W
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13977Informations de copyright
© 2021 Wiley Periodicals LLC.
Références
Akiel, M., Alsughayyir, J., Basudan, A. M., Alamri, H. S., Dera, A., Barhoumi, T., Al Subayyil, A. M., Basmaeil, Y. S., Aldakheel, F. M., Alakeel, R., Ghneim, H. K., Al-Sheikh, Y. A., Alraey, Y., Asiri, S., & Alfhili, M. A. (2021). Physcion induces hemolysis and premature phosphatidylserine externalization in human erythrocytes. Biological &/and Pharmaceutical Bulletin, 44(3), 372-378. https://doi.org/10.1248/bpb.b20-00744
Al Mamun Bhuyan, A., & Lang, F. (2018). Inhibition of erythrocyte cell membrane scrambling following energy depletion and hyperosmotic shock by alectinib. Cellular Physiology and Biochemistry, 51(5), 1996-2009. https://doi.org/10.1159/000495777
Al Mamun Bhuyan, A., Ashiqul Haque, A., Sahu, I., Cao, H., Kormann, M. S. D., & Lang, F. (2017). Inhibition of suicidal erythrocyte death by volasertib. Cellular Physiology and Biochemistry, 43(4), 1472-1486. https://doi.org/10.1159/000481969
Al Mamun Bhuyan, A., Sahu, I., Cao, H., & Lang, F. (2018). Sonidegib, a novel inhibitor of suicidal erythrocyte death. Cellular Physiology and Biochemistry, 47(4), 1352-1364. https://doi.org/10.1159/000490820
Alamri, H. S., Alsughayyir, J., Akiel, M., Al-Sheikh, Y. A., Basudan, A. M., Dera, A., & Alfhili, M. A. (2021). Stimulation of calcium influx and CK1alpha by NF-kappaB antagonist [6]-Gingerol reprograms red blood cell longevity. Journal of Food Biochemistry, 45(1), e13545. https://doi.org/10.1111/jfbc.13545
Alfhili, M. A., Alsalmi, E., Aljedai, A., Alsughayyir, J., Abudawood, M., & Basudan, A. M. (2021). Calcium-oxidative stress signaling axis and casein kinase 1alpha mediate eryptosis and hemolysis elicited by novel p53 agonist inauhzin. Journal of Chemotherapy, 33, 1-11, https://doi.org/10.1080/1120009X.2021.1963616
Alfhili, M. A., Alsughayyir, J., & Basudan, A. B. (2021). Epidemic dropsy toxin, sanguinarine chloride, stimulates sucrose-sensitive hemolysis and breakdown of membrane phospholipid asymmetry in human erythrocytes. Toxicon, 199, 41-48. https://doi.org/10.1016/j.toxicon.2021.05.013
Alfhili, M. A., & Lee, M. H. (2021). Flow cytofluorometric analysis of molecular mechanisms of premature red blood cell death. Methods in Molecular Biology, 2326, 155-165. https://doi.org/10.1007/978-1-0716-1514-0_11
Alfhili, M. A., Nkany, M. B., Weidner, D. A., & Lee, M. H. (2019). Stimulation of eryptosis by broad-spectrum insect repellent N, N-Diethyl-3-methylbenzamide (DEET). Toxicology and Applied Pharmacology, 370, 36-43. https://doi.org/10.1016/j.taap.2019.03.011
Alfhili, M. A., Weidner, D. A., & Lee, M. H. (2019). Disruption of erythrocyte membrane asymmetry by triclosan is preceded by calcium dysregulation and p38 MAPK and RIP1 stimulation. Chemosphere, 229, 103-111. https://doi.org/10.1016/j.chemosphere.2019.04.211
Chang, W. H., Chen, C. H., & Lu, F. J. (2002). Different effects of baicalein, baicalin and wogonin on mitochondrial function, glutathione content and cell cycle progression in human hepatoma cell lines. Planta Medica, 68(2), 128-132. https://doi.org/10.1055/s-2002-20246
Chow, S. E., Chen, Y. W., Liang, C. A., Huang, Y. K., & Wang, J. S. (2012). Wogonin induces cross-regulation between autophagy and apoptosis via a variety of Akt pathway in human nasopharyngeal carcinoma cells. Journal of Cellular Biochemistry, 113(11), 3476-3485. https://doi.org/10.1002/jcb.24224
Chu, Y., Lv, X., Zhang, L., Fu, X., Song, S., Su, A., & Yun, Z. (2020). Wogonin inhibits in vitro herpes simplex virus type 1 and 2 infection by modulating cellular NF-kappaB and MAPK pathways. BMC Microbiology, 20(1), 227. https://doi.org/10.1186/s12866-020-01916-2
Floride, E., Foller, M., Ritter, M., & Lang, F. (2008). Caffeine inhibits suicidal erythrocyte death. Cellular Physiology and Biochemistry, 22(1-4), 253-260. https://doi.org/10.1159/000149803
Gao, J., Morgan, W. A., Sanchez-Medina, A., & Corcoran, O. (2011). The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. Toxicology and Applied Pharmacology, 254(3), 221-228. https://doi.org/10.1016/j.taap.2011.03.016
Gatidis, S., Zelenak, C., Fajol, A., Lang, E., Jilani, K., Michael, D., Qadri, S. M., & Lang, F. (2011). p38 MAPK activation and function following osmotic shock of erythrocytes. Cellular Physiology and Biochemistry, 28(6), 1279-1286. https://doi.org/10.1159/000335859
Ghashghaeinia, M., Cluitmans, J. C. A., Akel, A., Dreischer, P., Toulany, M., Köberle, M., Skabytska, Y., Saki, M., Biedermann, T., Duszenko, M., Lang, F., Wieder, T., & Bosman, G. J. C. G. M. (2012). The impact of erythrocyte age on eryptosis. British Journal of Haematology, 157(5), 606-614. https://doi.org/10.1111/j.1365-2141.2012.09100.x
Jemaa, M., Fezai, M., & Lang, F. (2017). Inhibition of suicidal erythrocyte death by reversine. Cellular Physiology and Biochemistry, 41(6), 2363-2373. https://doi.org/10.1159/000475654
Klarl, B. A., Lang, P. A., Kempe, D. S., Niemoeller, O. M., Akel, A., Sobiesiak, M., Eisele, K., Podolski, M., Huber, S. M., Wieder, T., & Lang, F. (2006). Protein kinase C mediates erythrocyte “programmed cell death” following glucose depletion. American Journal of Physiology. Cell Physiology, 290(1), C244-253. https://doi.org/10.1152/ajpcell.00283.2005
Kucherenko, Y., Geiger, C., Shumilina, E., Foller, M., & Lang, F. (2008). Inhibition of cation channels and suicidal death of human erythrocytes by zidovudine. Toxicology, 253(1-3), 62-69. https://doi.org/10.1016/j.tox.2008.08.012
Lang, E., Bissinger, R., Qadri, S. M., & Lang, F. (2017). Suicidal death of erythrocytes in cancer and its chemotherapy: A potential target in the treatment of tumor-associated anemia. International Journal of Cancer, 141(8), 1522-1528. https://doi.org/10.1002/ijc.30800
Lang, F., Lang, E., & Foller, M. (2012). Physiology and pathophysiology of eryptosis. Transfusion Medicine and Hemotherapy, 39(5), 308-314. https://doi.org/10.1159/000342534
Lang, P. A., Kaiser, S., Myssina, S., Wieder, T., Lang, F., & Huber, S. M. (2003). Role of Ca2+-activated K+ channels in human erythrocyte apoptosis. American Journal of Physiology. Cell Physiology, 285(6), C1553-1560. https://doi.org/10.1152/ajpcell.00186.2003
Lin, C. C., Kuo, C. L., Lee, M. H., Lai, K. C., Lin, J. P., Yang, J. S., & Chung, J. G. (2011). Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. International Journal of Oncology, 39(1), 217-224. https://doi.org/10.3892/ijo.2011.1027
Liu, J., Bhuyan, A. A. M., Ma, K., Zhang, S., Cheng, A., & Lang, F. (2020). Inhibition of suicidal erythrocyte death by pyrogallol. Molecular Biology Reports, 47(7), 5025-5032. https://doi.org/10.1007/s11033-020-05568-3
Myssina, S., Lang, P. A., Kempe, D. S., Kaiser, S., Huber, S. M., Wieder, T., & Lang, F. (2004). Cl- channel blockers NPPB and niflumic acid blunt Ca(2+)-induced erythrocyte 'apoptosis'. Cellular Physiology and Biochemistry, 14(4-6), 241-248. https://doi.org/10.1159/000080333
Nicolay, J. P., Liebig, G., Niemoeller, O. M., Koka, S., Ghashghaeinia, M., Wieder, T., Haendeler, J., Busse, R., & Lang, F. (2008). Inhibition of suicidal erythrocyte death by nitric oxide. Pflugers Archiv European Journal of Physiology, 456(2), 293-305. https://doi.org/10.1007/s00424-007-0393-1
Niemoeller, O. M., Bentzen, P. J., Lang, E., & Lang, F. (2007). Adenosine protects against suicidal erythrocyte death. Pflugers Archiv European Journal of Physiology, 454(3), 427-439. https://doi.org/10.1007/s00424-007-0218-2
Özmen, A., Madlener, S., Bauer, S., Krasteva, S., Vonach, C., Giessrigl, B., Gridling, M., Viola, K., Stark, N., Saiko, P., Michel, B., Fritzer-Szekeres, M., Szekeres, T., Askin-Celik, T., Krenn, L., & Krupitza, G. (2010). In vitro anti-leukemic activity of the ethno-pharmacological plant Scutellaria orientalis ssp. carica endemic to western Turkey. Phytomedicine, 17(1), 55-62. https://doi.org/10.1016/j.phymed.2009.06.001
Pretorius, E., du Plooy, J. N., & Bester, J. (2016). A Comprehensive Review on Eryptosis. Cellular Physiology and Biochemistry, 39(5), 1977-2000. https://doi.org/10.1159/000447895
Qadri, S. M., Foller, M., & Lang, F. (2009). Inhibition of suicidal erythrocyte death by resveratrol. Life Sciences, 85(1-2), 33-38. https://doi.org/10.1016/j.lfs.2009.04.015
Qadri, S. M., Mahmud, H., Foller, M., & Lang, F. (2009). Inhibition of suicidal erythrocyte death by xanthohumol. Journal of Agriculture and Food Chemistry, 57(16), 7591-7595. https://doi.org/10.1021/jf900773w
Reinhart, W. H., & Schulzki, T. (2011). Metabolic depletion decreases the aggregability of erythrocytes. Clin Hemorheol Microcirc, 49(1-4), 451-461. https://doi.org/10.3233/CH-2011-1495
Shaik, N., Zbidah, M., & Lang, F. (2012). Inhibition of Ca(2+) entry and suicidal erythrocyte death by naringin. Cellular Physiology and Biochemistry, 30(3), 678-686. https://doi.org/10.1159/000341448
Sultan, S. A., Khawaji, M. H., Alsughayyir, J., Alfhili, M. A., Alamri, H. S., & Alrfaei, B. M. (2020). Antileukemic activity of sulfoxide nutraceutical allicin against THP-1 cells is associated with premature phosphatidylserine exposure in human erythrocytes. Saudi Journal of Biological Sciences, 27(12), 3376-3384. https://doi.org/10.1016/j.sjbs.2020.09.005
Tsai, C. F., Yeh, W. L., Huang, S. M., Tan, T. W., & Lu, D. Y. (2012). Wogonin induces reactive oxygen species production and cell apoptosis in human glioma cancer cells. International Journal of Molecular Sciences, 13(8), 9877-9892. https://doi.org/10.3390/ijms13089877
Visweshwar, N., Jaglal, M., Sokol, L., & Zuckerman, K. (2018). Chemotherapy-related anemia. Annals of Hematology, 97(2), 375-376. https://doi.org/10.1007/s00277-017-3155-y
Vota, D. M., Crisp, R. L., Nesse, A. B., & Vittori, D. C. (2012). Oxidative stress due to aluminum exposure induces eryptosis which is prevented by erythropoietin. Journal of Cellular Biochemistry, 113(5), 1581-1589. https://doi.org/10.1002/jcb.24026
Wang, C.-Z., Calway, T. D., Wen, X.-D., Smith, J., Yu, C., Wang, Y., Mehendale, S. R., & Yuan, C.-S. (2013). Hydrophobic flavonoids from Scutellaria baicalensis induce colorectal cancer cell apoptosis through a mitochondrial-mediated pathway. International Journal of Oncology, 42(3), 1018-1026. https://doi.org/10.3892/ijo.2013.1777
Wang, L., Zhang, H., Chen, B., Xia, G., Wang, S., Cheng, J., & Wang, X. (2012). Effect of magnetic nanoparticles on apoptosis and cell cycle induced by wogonin in Raji cells. Int J Nanomedicine, 7, 789-798. https://doi.org/10.2147/IJN.S28089
Wozniak, D., Drys, A., & Matkowski, A. (2015). Antiradical and antioxidant activity of flavones from Scutellariae baicalensis radix. Natural Product Research, 29(16), 1567-1570. https://doi.org/10.1080/14786419.2014.983920
Wu, X., Zhang, H., Salmani, J. M., Fu, R., & Chen, B. (2016). Advances of wogonin, an extract from Scutellaria baicalensis, for the treatment of multiple tumors. OncoTargets and Therapy, 9, 2935-2943. https://doi.org/10.2147/OTT.S105586
Xu, M., Lu, N. A., Zhang, H., Dai, Q., Wei, L., Li, Z., You, Q., & Guo, Q. (2013). Wogonin induced cytotoxicity in human hepatocellular carcinoma cells by activation of unfolded protein response and inactivation of AKT. Hepatology Research, 43(8), 890-905. https://doi.org/10.1111/hepr.12036
Yu, J. S., & Kim, A. K. (2011). Wogonin induces apoptosis by activation of ERK and p38 MAPKs signaling pathways and generation of reactive oxygen species in human breast cancer cells. Molecules and Cells, 31(4), 327-335. https://doi.org/10.1007/s10059-011-0041-7
Zhang, M., Liu, L.-P., Chen, Y., Tian, X.-Y., Qin, J., Wang, D., Li, Z., & Mo, S.-L. (2013). Wogonin induces apoptosis in RPMI 8226, a human myeloma cell line, by downregulating phospho-Akt and overexpressing Bax. Life Sciences, 92(1), 55-62. https://doi.org/10.1016/j.lfs.2012.10.023
Zhao, K., Wei, L., Hui, H., Dai, Q., You, Q. D., Guo, Q. L., & Lu, N. (2014). Wogonin suppresses melanoma cell B16-F10 invasion and migration by inhibiting Ras-medicated pathways. PLoS One, 9(9), e106458. https://doi.org/10.1371/journal.pone.0106458
Zierle, J., Bissinger, R., & Lang, F. (2016). Inhibition by teriflunomide of erythrocyte cell membrane scrambling following energy depletion, oxidative stress and ionomycin. Cellular Physiology and Biochemistry, 39(5), 1877-1890. https://doi.org/10.1159/000447886