Dysregulation of mitochondrial sirtuin genes is associated with human male infertility.
human
infertility
male
mitochondria
semen
sirtuins
Journal
Andrologia
ISSN: 1439-0272
Titre abrégé: Andrologia
Pays: Germany
ID NLM: 0423506
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
revised:
22
08
2021
received:
17
06
2021
accepted:
29
09
2021
pubmed:
20
10
2021
medline:
12
1
2022
entrez:
19
10
2021
Statut:
ppublish
Résumé
Mitochondrial sirtuins (SIRT3, SIRT4, SIRT5) are post-translational modifiers that regulate energy production, body homeostasis and mitochondrial activities via different substrates in response to environmental stressors. The present study aimed at assessing the expression of SIRT3, SIRT4, and SIRT5 in the semen of infertile men. Expression analysis was performed using q-RT PCR. All mitochondrial sirtuin genes were significantly down-regulated in the semen of infertile men compared to fertile men. Mitochondrial sirtuin genes expression levels were correlated with mitochondrial HSP90 expression. HSP90 expression was positively correlated with SIRT3, SIRT4 and SIRT5 expression in the semen of fertile men, while a negative correlation was observed between HSP90 in the semen of infertile men and mitochondrial sirtuin genes in the semen of fertile men. These data suggest that dysregulation of mitochondrial sirtuin genes causes mitochondrial dysfunction due to stress, which appears to be associated with human male infertility by compromising functional and structural sperm integrity.
Substances chimiques
Mitochondrial Proteins
0
SIRT3 protein, human
EC 3.5.1.-
SIRT4 protein, human
EC 3.5.1.-
SIRT5 protein, human
EC 3.5.1.-
Sirtuin 3
EC 3.5.1.-
Sirtuins
EC 3.5.1.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14274Subventions
Organisme : Higher Education Commission of Pakistan
ID : NRPU 3729
Informations de copyright
© 2021 Wiley-VCH GmbH.
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