Visualizing transfer of microbial biomolecules by outer membrane vesicles in microbe-host-communication in vivo.

Animals Bacterial Outer Membrane Proteins / genetics Escherichia coli / metabolism Gastrointestinal Microbiome / genetics Mice
Cre-Loxp extracellular vesicles inflammation intestinal stem cells microbiome outer membrane vesicles

Journal

Journal of extracellular vesicles
ISSN: 2001-3078
Titre abrégé: J Extracell Vesicles
Pays: United States
ID NLM: 101610479

Informations de publication

Date de publication:
10 2021
Historique:
revised: 24 09 2021
received: 30 04 2021
accepted: 28 09 2021
entrez: 19 10 2021
pubmed: 20 10 2021
medline: 26 2 2022
Statut: ppublish

Résumé

The intestinal microbiota influences mammalian host physiology in health and disease locally in the gut but also in organs devoid of direct contact with bacteria such as the liver and brain. Extracellular vesicles (EVs) or outer membrane vesicles (OMVs) released by microbes are increasingly recognized for their potential role as biological shuttle systems for inter-kingdom communication. However, physiologically relevant evidence for the transfer of functional biomolecules from the intestinal microbiota to individual host cells by OMVs in vivo is scarce. By introducing Escherichia coli engineered to express Cre-recombinase (E. coli

Identifiants

DOI: 10.1002/jev2.12159 PMID: 34664784 PMC: PMC8524437
pubmed: 34664784
doi: 10.1002/jev2.12159
pmc: PMC8524437
doi:

Substances chimiques

Bacterial Outer Membrane Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

e12159

Subventions

Organisme : BLRD VA
ID : IK6 BX005692
Pays : United States
Organisme : NCI NIH HHS
ID : UG3 CA241703
Pays : United States
Organisme : VA
ID : #IK6BX005692
Pays : United States
Organisme : NCI NIH HHS
ID : UH3 CA241703
Pays : United States
Organisme : NIH HHS
ID : UG3CA241703
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL133575
Pays : United States
Organisme : VA
ID : 1I01BX003928-01A2
Pays : United States
Organisme : BLRD VA
ID : I01 BX003928
Pays : United States

Informations de copyright

© 2021 The Authors. Journal of Extracellular Vesicles published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles.

Références

J Clin Microbiol. 2001 May;39(5):1956-9
pubmed: 11326021
J Infect Dis. 1980 Oct;142(4):556-68
pubmed: 6108344
Annu Rev Microbiol. 2010;64:163-84
pubmed: 20825345
Cell Host Microbe. 2014 May 14;15(5):623-35
pubmed: 24746552
Nat Rev Microbiol. 2015 Oct;13(10):605-19
pubmed: 26373371
J Infect Dis. 1982 Oct;146(4):568
pubmed: 6126510
Nature. 2007 Oct 25;449(7165):1003-7
pubmed: 17934449
J Clin Invest. 2003 Sep;112(5):693-706
pubmed: 12952918
Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):E7321-E7330
pubmed: 28808033
PLoS Pathog. 2010 Jan 15;6(1):e1000724
pubmed: 20090836
Nat Rev Immunol. 2015 Jun;15(6):375-87
pubmed: 25976515
Pediatr Surg Int. 2020 Dec;36(12):1471-1479
pubmed: 33084932
Biochem Soc Trans. 2018 Oct 19;46(5):1021-1027
pubmed: 30154095
PLoS Biol. 2014 Jun 03;12(6):e1001874
pubmed: 24893313
Gut. 2015 Apr;64(4):601-10
pubmed: 25379949
FASEB J. 2019 Dec;33(12):13412-13422
pubmed: 31545910
Proteomics Clin Appl. 2016 Oct;10(9-10):897-909
pubmed: 27480505
Transfusion. 2016 May;56(5):1138-47
pubmed: 26865079
J Neuroinflammation. 2019 Mar 1;16(1):53
pubmed: 30823925
J Bacteriol. 1995 Jul;177(14):3998-4008
pubmed: 7608073
Regen Med. 2011 Nov;6(6):743-55
pubmed: 22050526
Nat Rev Immunol. 2017 Apr;17(4):219-232
pubmed: 28260787
Sci Rep. 2015 Oct 29;5:15878
pubmed: 26510393
Microbiome. 2020 Jun 8;8(1):88
pubmed: 32513301
Nat Protoc. 2016 Sep;11(9):1724-43
pubmed: 27560176
Microbiol Res. 2015 Jan;170:1-9
pubmed: 25458555
FEMS Microbiol Lett. 2000 Jan 15;182(2):259-64
pubmed: 10620676
PLoS Pathog. 2017 Nov 29;13(11):e1006760
pubmed: 29186191
Annu Rev Immunol. 2012;30:149-73
pubmed: 22224779
Infect Immun. 2012 Jun;80(6):1948-57
pubmed: 22409932
Cell. 2015 Apr 23;161(3):674-690
pubmed: 25910214
Trends Microbiol. 2018 May;26(5):401-410
pubmed: 29548832
Obesity (Silver Spring). 2018 May;26(5):792-800
pubmed: 29687645
J Pathol. 1999 Jun;188(2):220-6
pubmed: 10398168
Cell Host Microbe. 2015 May 13;17(5):672-80
pubmed: 25974305
Nature. 2011 Sep 14;477(7364):335-9
pubmed: 21921917
Cell Host Microbe. 2012 Oct 18;12(4):509-20
pubmed: 22999859
Open Biol. 2018 Sep 12;8(9):
pubmed: 30209039
Front Immunol. 2020 Apr 15;11:646
pubmed: 32351509
Science. 2016 May 27;352(6289):1116-20
pubmed: 27230380
J Control Release. 2020 Jul 10;323:253-268
pubmed: 32333919
Front Cell Infect Microbiol. 2019 May 08;9:148
pubmed: 31139578
Sci Rep. 2017 Mar 17;7:44061
pubmed: 28303895
Cell Microbiol. 2016 Nov;18(11):1508-1517
pubmed: 27529760
Microbiol Mol Biol Rev. 2010 Mar;74(1):81-94
pubmed: 20197500
PLoS Pathog. 2016 Jun 13;12(6):e1005672
pubmed: 27295279
J Hepatol. 2020 Mar;72(3):558-577
pubmed: 31622696
Cell Rep. 2018 Oct 30;25(5):1346-1358
pubmed: 30380423
Cell. 2014 Mar 27;157(1):121-41
pubmed: 24679531
Front Microbiol. 2018 Oct 11;9:2268
pubmed: 30369908
Science. 2020 Feb 7;367(6478):
pubmed: 32029601
Cell Rep. 2020 Jul 14;32(2):107881
pubmed: 32668250
Oncoimmunology. 2015 Mar 19;4(6):e1008371
pubmed: 26155418
Gut. 2005 Dec;54(12):1802-9
pubmed: 16284290
Annu Rev Physiol. 2009;71:241-60
pubmed: 18808327
Front Microbiol. 2020 Feb 06;11:57
pubmed: 32117106
Science. 2002 Feb 22;295(5559):1487
pubmed: 11859186
Microbiol Spectr. 2016 Feb;4(1):
pubmed: 26999395
J Proteome Res. 2017 Nov 3;16(11):4060-4072
pubmed: 28948796
Sci Immunol. 2019 Feb 8;4(32):
pubmed: 30737355
Cell Host Microbe. 2016 Apr 13;19(4):434-41
pubmed: 27049583
J Immunol. 2017 Jan 1;198(1):452-460
pubmed: 27895169
Mol Cell. 2020 May 21;78(4):584-596
pubmed: 32234490
Cell Host Microbe. 2020 Feb 12;27(2):225-237.e8
pubmed: 31901519
Small. 2015 Jan 27;11(4):456-61
pubmed: 25196673
Nat Protoc. 2006;1(1):153-61
pubmed: 17406227
Nature. 2007 Oct 18;449(7164):804-10
pubmed: 17943116
J Exp Med. 1975 Feb 1;141(2):297-305
pubmed: 803544
Gastroenterology. 2014 May;146(6):1470-6
pubmed: 24631493
Mol Syst Biol. 2014 Oct 30;10:757
pubmed: 25358341
PLoS Biol. 2020 Mar 16;18(3):e3000643
pubmed: 32176686
Stem Cell Reports. 2014 Aug 12;3(2):234-41
pubmed: 25254337
Front Genet. 2020 Jul 17;11:700
pubmed: 32765582
Commun Biol. 2018 Apr 5;1:23
pubmed: 30271910
Nat Med. 2012 Mar 11;18(4):618-23
pubmed: 22406745
PLoS One. 2016 Aug 08;11(8):e0160440
pubmed: 27500956
PLoS One. 2019 Apr 11;14(4):e0215324
pubmed: 30973950
Biochem Soc Trans. 2019 Aug 30;47(4):1005-1012
pubmed: 31320501
Int J Exp Pathol. 2000 Apr;81(2):117-43
pubmed: 10762441
Microbiology (Reading). 2004 Jul;150(Pt 7):2161-2169
pubmed: 15256559

Auteurs

Miriam Bittel (M)

Department of Medicine 1, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
ORCID: 0000-0002-7673-9501

Patrick Reichert (P)

Department of Medicine 1, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.

Ilann Sarfati (I)

Department of Medicine 1, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Deutsches Zentrum Immuntherapie, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.

Anja Dressel (A)

Department of Medicine 1, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Deutsches Zentrum Immuntherapie, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.

Stefanie Leikam (S)

Department of Medicine 1, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.

Stefan Uderhardt (S)

Department of Internal Medicine 3, University Hospital Erlangen and Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.
Exploratory Research Unit, Optical Imaging Centre Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Iris Stolzer (I)

Department of Medicine 1, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Deutsches Zentrum Immuntherapie, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.

Tuan Anh Phu (TA)

Northern California Institute for Research and Education, San Francisco, California, USA.

Martin Ng (M)

Northern California Institute for Research and Education, San Francisco, California, USA.

Ngan K Vu (NK)

Northern California Institute for Research and Education, San Francisco, California, USA.

Stefan Tenzer (S)

Institute of Immunology, University Medical Centre of the Johannes-Gutenberg University Mainz, Mainz, Germany.
Research Centre for Immunotherapy (FZI), University Medical Center of the Johannes-Gutenberg University Mainz, Mainz, Germany.

Ute Distler (U)

Institute of Immunology, University Medical Centre of the Johannes-Gutenberg University Mainz, Mainz, Germany.
Research Centre for Immunotherapy (FZI), University Medical Center of the Johannes-Gutenberg University Mainz, Mainz, Germany.

Stefan Wirtz (S)

Department of Medicine 1, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Deutsches Zentrum Immuntherapie, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.

Veit Rothhammer (V)

Neurology Department (Experimental Glia Biology), University Hospital Erlangen and Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Markus F Neurath (MF)

Department of Medicine 1, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Deutsches Zentrum Immuntherapie, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.

Robert L Raffai (RL)

Department of Surgery, Division of Vascular and Endovascular Surgery, University of California San Francisco, San Francisco, California, USA.
Department of Veterans Affairs, Surgical Service (112G), San Francisco VA Medical Centre, San Francisco, California, USA.

Claudia Günther (C)

Department of Medicine 1, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Deutsches Zentrum Immuntherapie, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.

Stefan Momma (S)

Institute of Neurology (Edinger Institute), Goethe University, Frankfurt am Main, Germany.
ORCID: 0000-0001-7816-5145

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Visualizing transfer of microbial biomolecules...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de la membrane externe bactérienne › Visualizing transfer of microbial biomolecules...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Visualizing transfer of microbial biomolecules...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › Visualizing transfer of microbial biomolecules...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Visualizing transfer of microbial biomolecules...