Maternal SARS-CoV-2 infection elicits sexually dimorphic placental immune responses.
Journal
Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086
Informations de publication
Date de publication:
27 Oct 2021
27 Oct 2021
Historique:
pubmed:
20
10
2021
medline:
3
11
2021
entrez:
19
10
2021
Statut:
ppublish
Résumé
There is a persistent bias toward higher prevalence and increased severity of coronavirus disease 2019 (COVID-19) in males. Underlying mechanisms accounting for this sex difference remain incompletely understood. Interferon responses have been implicated as a modulator of COVID-19 disease in adults and play a key role in the placental antiviral response. Moreover, the interferon response has been shown to alter Fc receptor expression and therefore may affect placental antibody transfer. Here, we examined the intersection of maternal-fetal antibody transfer, viral-induced placental interferon responses, and fetal sex in pregnant women infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Placental Fc receptor abundance, interferon-stimulated gene (ISG) expression, and SARS-CoV-2 antibody transfer were interrogated in 68 human pregnancies. Sexually dimorphic expression of placental Fc receptors, ISGs and proteins, and interleukin-10 was observed after maternal SARS-CoV-2 infection, with up-regulation of these features in placental tissue of pregnant individuals with male fetuses. Reduced maternal SARS-CoV-2–specific antibody titers and impaired placental antibody transfer were also observed in pregnancies with a male fetus. These results demonstrate fetal sex-specific maternal and placental adaptive and innate immune responses to SARS-CoV-2.
Identifiants
pubmed: 34664987
doi: 10.1126/scitranslmed.abi7428
pmc: PMC8784281
mid: NIHMS1758129
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
eabi7428Subventions
Organisme : NIAID NIH HHS
ID : R01 AI042790
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI146785
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI069412
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI142790
Pays : United States
Organisme : NIMH NIH HHS
ID : U54 MH118919
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL146963
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL143183
Pays : United States
Organisme : NIMH NIH HHS
ID : F32 MH116604
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD094937
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD100022
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI135995
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA260476
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI080289
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI145071
Pays : United States
Organisme : NICHD NIH HHS
ID : K12 HD103096
Pays : United States
Commentaires et corrections
Type : UpdateOf
Type : CommentIn
Type : ErratumIn
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