A brief review of the current knowledge on environmental toxicants and risk of pediatric cancers.

The incidence of pediatric cancers has steadily increased since 1975, which could suggest that other exogenous factors are accounting for an increasing proportion of cases. There has been growing concern over environmental exposures (i.e., toxicants) the on development of pediatric cancers. However, identifying environmental exposures on childhood cancer risk has been challenging because these outcomes are infrequent compared to cancer in adults, and it is difficult to estimate exposure during specific critical periods of development (e.g., pre-conception,