FDA approved L-type channel blocker Nifedipine reduces cell death in hypoxic A549 cells through modulation of mitochondrial calcium and superoxide generation.
Calcium channel blocker
Hypoxia
Mitochondrial calcium
Nifedipine
Reactive oxygen species (ROS)
SARS-Cov-2
Journal
Free radical biology & medicine
ISSN: 1873-4596
Titre abrégé: Free Radic Biol Med
Pays: United States
ID NLM: 8709159
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
26
06
2021
revised:
26
08
2021
accepted:
29
08
2021
pubmed:
20
10
2021
medline:
15
12
2021
entrez:
19
10
2021
Statut:
ppublish
Résumé
As hypoxia is a major driver for the pathophysiology of COVID-19, it is crucial to characterize the hypoxic response at the cellular and molecular levels. In order to augment drug repurposing with the identification of appropriate molecular targets, investigations on therapeutics preventing hypoxic cell damage is required. In this work, we propose a hypoxia model based on alveolar lung epithelial cells line using chemical inducer, CoCl
Identifiants
pubmed: 34666149
pii: S0891-5849(21)00762-0
doi: 10.1016/j.freeradbiomed.2021.08.245
pmc: PMC8520174
pii:
doi:
Substances chimiques
Calcium Channel Blockers
0
Superoxides
11062-77-4
Nifedipine
I9ZF7L6G2L
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
189-200Informations de copyright
Copyright © 2021. Published by Elsevier Inc.
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