An appraisal of antigen identification and IgG effector functions driving host immune responses in multiple sclerosis.
Antigen
Effector function
IgG
Multiple sclerosis (MS)
Oligoclonal band
Journal
Multiple sclerosis and related disorders
ISSN: 2211-0356
Titre abrégé: Mult Scler Relat Disord
Pays: Netherlands
ID NLM: 101580247
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
31
07
2021
revised:
05
10
2021
accepted:
10
10
2021
pubmed:
20
10
2021
medline:
17
12
2021
entrez:
19
10
2021
Statut:
ppublish
Résumé
Increased immunoglobulin G (IgG) antibodies and oligoclonal bands (OCB) are the most characteristic features of multiple sclerosis (MS), a neuroinflammatory demyelinating disease with neurodegeneration at chronic stages. OCB are shown to be associated with disease activity and brain atrophy. Despite intensive research over the last several decades, the antigen specificities of the IgG in MS have remained elusive. We present evidence which supports that intrathecal IgG is not driven by antigen-stimulation, therefore provide reasoning for failed MS antigen identification. Further, the presence of co-deposition of IgG and activated complement products in MS lesions suggest that the IgG effector functions may play a critical role in disease pathogenesis.
Identifiants
pubmed: 34666240
pii: S2211-0348(21)00595-2
doi: 10.1016/j.msard.2021.103328
pii:
doi:
Substances chimiques
Immunoglobulin G
0
Oligoclonal Bands
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
103328Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.