Short-term high-fat feeding exacerbates degeneration in retinitis pigmentosa by promoting retinal oxidative stress and inflammation.
Animals
Cell Death
Diet, High-Fat
/ adverse effects
Disease Models, Animal
Electroretinography
Female
Gastrointestinal Microbiome
Glucose Intolerance
Male
Mice
Mice, Inbred C57BL
Mice, Mutant Strains
Models, Biological
Oxidative Stress
Photoreceptor Cells, Vertebrate
/ pathology
Retina
/ metabolism
Retinal Degeneration
/ etiology
Retinitis Pigmentosa
/ etiology
cell death
gut microbiome
neurodegeneration
retinal degeneration
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
26 10 2021
26 10 2021
Historique:
accepted:
11
09
2021
entrez:
20
10
2021
pubmed:
21
10
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
A high-fat diet (HFD) can induce hyperglycemia and metabolic syndromes that, in turn, can trigger visual impairment. To evaluate the acute effects of HFD feeding on retinal degeneration, we assessed retinal function and morphology, inflammatory state, oxidative stress, and gut microbiome in dystrophic retinal degeneration 10 (rd10) mice, a model of retinitis pigmentosa, fed an HFD for 2 to 3 wk. Short-term HFD feeding impaired retinal responsiveness and visual acuity and enhanced photoreceptor degeneration, microglial cell activation, and Müller cell gliosis. HFD consumption also triggered the expression of inflammatory and oxidative markers in rd10 retinas. Finally, an HFD caused gut microbiome dysbiosis, increasing the abundance of potentially proinflammatory bacteria. Thus, HFD feeding drives the pathological processes of retinal degeneration by promoting oxidative stress and activating inflammatory-related pathways. Our findings suggest that consumption of an HFD could accelerate the progression of the disease in patients with retinal degenerative disorders.
Identifiants
pubmed: 34667124
pii: 2100566118
doi: 10.1073/pnas.2100566118
pmc: PMC8639377
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no competing interest.
Références
EMBO Mol Med. 2016 Dec 1;8(12):1366-1379
pubmed: 27861126
Invest Ophthalmol Vis Sci. 2015 May;56(5):3041-50
pubmed: 26024088
Cell Biochem Funct. 2013 Jan;31(1):65-74
pubmed: 22915345
Glia. 2018 Feb;66(2):295-310
pubmed: 29034506
Curr Opin Clin Nutr Metab Care. 2015 Sep;18(5):515-20
pubmed: 26154278
Nat Commun. 2018 Jul 18;9(1):2802
pubmed: 30022049
PLoS One. 2017 May 25;12(5):e0177998
pubmed: 28542454
Mol Vis. 2008 Jun 10;14:1075-80
pubmed: 18552981
Front Cell Neurosci. 2019 Feb 27;13:59
pubmed: 30873007
J Biol Chem. 2012 Jul 13;287(29):24378-86
pubmed: 22645141
BMC Ophthalmol. 2017 Jul 24;17(1):129
pubmed: 28738845
Brain Behav Immun. 2014 Aug;40:9-17
pubmed: 24662056
Cell Death Dis. 2018 Mar 2;9(3):350
pubmed: 29500424
Oncotarget. 2016 Oct 18;7(42):67808-67827
pubmed: 27661129
Front Immunol. 2019 Oct 18;10:2464
pubmed: 31681334
Sci Rep. 2016 Sep 14;6:33356
pubmed: 27624537
World J Diabetes. 2017 Feb 15;8(2):56-65
pubmed: 28265343
Surv Ophthalmol. 2018 Nov - Dec;63(6):769-781
pubmed: 29551596
Exp Eye Res. 2017 Sep;162:104-109
pubmed: 28757158
PLoS One. 2016 Jan 08;11(1):e0145293
pubmed: 26745177
Neurobiol Dis. 2012 Jan;45(1):529-38
pubmed: 21971528
J Enzyme Inhib Med Chem. 2017 Dec;32(1):522-526
pubmed: 28114834
Am J Physiol Endocrinol Metab. 2013 Aug 1;305(3):E388-95
pubmed: 23736545
Retina. 2015 Mar;35(3):459-66
pubmed: 25207946
Am J Physiol Regul Integr Comp Physiol. 2010 Oct;299(4):R1082-90
pubmed: 20702796
Nat Med. 2006 Jan;12(1):62-6
pubmed: 16397571
Transl Vis Sci Technol. 2020 Oct 14;9(11):18
pubmed: 33117609
Biochem Biophys Res Commun. 2017 Nov 4;493(1):731-736
pubmed: 28865961
Adv Nutr. 2020 Jan 1;11(1):77-91
pubmed: 31268137
Int J Obes (Lond). 2017 Jan;41(1):149-158
pubmed: 27773938
Antioxidants (Basel). 2020 Aug 17;9(8):
pubmed: 32824523
Diabetologia. 2014 Feb;57(2):413-23
pubmed: 24201577
J Neuroimmunol. 2010 Feb 26;219(1-2):25-32
pubmed: 20004026
Food Funct. 2017 Feb 22;8(2):629-650
pubmed: 28067391
PLoS One. 2013 Sep 12;8(9):e74223
pubmed: 24069283
Aging Dis. 2015 Oct 01;6(5):304-21
pubmed: 26425386
Physiol Behav. 2015 Dec 1;152(Pt B):363-71
pubmed: 26066731
Acta Histochem. 2017 Jan;119(1):1-9
pubmed: 27265809
Cell Physiol Biochem. 2020 Feb 7;54(1):142-159
pubmed: 32028545
PLoS One. 2013 Oct 18;8(10):e78864
pubmed: 24205333
Sci Rep. 2020 Nov 2;10(1):18601
pubmed: 33139746
Cells. 2020 Mar 28;9(4):
pubmed: 32231133
Nutrients. 2018 Nov 05;10(11):
pubmed: 30400586
Oxid Med Cell Longev. 2017;2017:4076518
pubmed: 28424744
Nutrients. 2019 Oct 25;11(11):
pubmed: 31731503
Invest Ophthalmol Vis Sci. 2020 Aug 3;61(10):1
pubmed: 32744596
Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2367-80
pubmed: 25788653
Diabetes. 1988 Sep;37(9):1163-7
pubmed: 3044882
Ageing Res Rev. 2010 Oct;9(4):399-417
pubmed: 20444434
Neurobiol Learn Mem. 2019 Jan;157:41-47
pubmed: 30471346
J Proteome Res. 2016 Apr 1;15(4):1350-9
pubmed: 26939627
Arch Ophthalmol. 2009 May;127(5):674-80
pubmed: 19433719
mSystems. 2017 Jan 31;2(1):
pubmed: 28168224
J Neurosci Res. 2003 Apr 1;72(1):125-31
pubmed: 12645086
Ocul Immunol Inflamm. 2018;26(1):37-50
pubmed: 28146368
Ophthalmic Res. 2015;53(3):162-7
pubmed: 25832811
Invest Ophthalmol Vis Sci. 2020 Feb 7;61(2):20
pubmed: 32058563
Exp Eye Res. 2021 Mar;204:108440
pubmed: 33444582
Signal Transduct Target Ther. 2017;2:
pubmed: 29158945
Sci Rep. 2021 Mar 23;11(1):6692
pubmed: 33758301
Lipids. 2017 Jun;52(6):499-511
pubmed: 28429150
Invest Ophthalmol Vis Sci. 2002 Sep;43(9):2834-40
pubmed: 12202499
J Exp Med. 2019 Nov 4;216(11):2602-2618
pubmed: 31420376
Exp Eye Res. 2014 Mar;120:175-85
pubmed: 24495949