Effects of golden tomato extract on skin appearance-outlook into gene expression in cultured dermal fibroblasts and on trans-epidermal water loss and skin barrier in human subjects.
antioxidant
fibroblasts
olfactory receptors
phytoene & phytofluene
transepidermal water loss (TEWL)
Journal
Journal of cosmetic dermatology
ISSN: 1473-2165
Titre abrégé: J Cosmet Dermatol
Pays: England
ID NLM: 101130964
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
received:
18
08
2021
accepted:
24
09
2021
pubmed:
21
10
2021
medline:
20
7
2022
entrez:
20
10
2021
Statut:
ppublish
Résumé
Two experiments were performed to test the effects of rich tomato extract (Golden Tomato Extract, GTE) on human skin. In one experiment, the effects of this extract on gene expression in cultured human dermal fibroblasts were examined. In a second experiment, human subjects consumed the extract and trans-epidermal water loss (TEWL), and aspects of skin appearance were monitored. Primary human dermal fibroblasts in culture were treated with the extract. After six hours, RNA was extracted, and gene expression was examined using Affymetrix Human Clariom D array processing. For the clinical study, 65 human subjects consumed a capsule once a day for 16 weeks, and various skin parameters were assessed at predetermined time intervals. Among the genes upregulated by GTE are genes that augment innate immunity, enhance DNA repair, and the ability to detoxify xenobiotics. GTE significantly reduced TEWL in subjects who had high TEWL at baseline, but it had no effect on TEWL in subjects who had lower TEWL at baseline. Golden tomato extract may provide benefits to the skin by enhancing innate immunity and other defense mechanisms in the dermis and by providing antioxidants to the skin surface to optimize TEWL and the appearance of the skin.
Identifiants
pubmed: 34668310
doi: 10.1111/jocd.14527
pmc: PMC9545714
doi:
Substances chimiques
Water
059QF0KO0R
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3022-3030Subventions
Organisme : Lycored
Informations de copyright
© 2021 Lycored. Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.
Références
PLoS One. 2021 Mar 17;16(3):e0248183
pubmed: 33730073
Biochim Biophys Acta. 1987 Sep 25;921(2):191-7
pubmed: 3651483
J Lipid Res. 2018 Dec;59(12):2360-2367
pubmed: 30361410
Contact Dermatitis. 2018 Aug;79(2):59-66
pubmed: 29607504
J Lipid Res. 1985 Jun;26(6):761-6
pubmed: 4031654
Crit Rev Oral Biol Med. 1995;6(2):109-18
pubmed: 7548618
Food Funct. 2014 Feb;5(2):285-90
pubmed: 24323485
Hautarzt. 2006 Apr;57(4):291-6
pubmed: 16477469
Drug Discov Today. 2019 Sep;24(9):1899-1910
pubmed: 31176740
Nutrients. 2019 May 16;11(5):
pubmed: 31100970
Nutrients. 2018 Jun 25;10(7):
pubmed: 29941810
Int J Vitam Nutr Res. 2020 Oct;90(5-6):493-513
pubmed: 31303127
Skin Pharmacol Physiol. 2019;32(2):101-108
pubmed: 30836363
Antimicrob Agents Chemother. 2012 Mar;56(3):1157-61
pubmed: 22155833
J Lipid Res. 1983 Jun;24(6):759-65
pubmed: 6886564
J Cosmet Dermatol. 2018 Jun;17(3):471-476
pubmed: 29663701
Photochem Photobiol. 2002 May;75(5):503-6
pubmed: 12017476
J Cosmet Dermatol. 2019 Jun;18(3):857-861
pubmed: 30160004
Int Immunol. 2019 Aug 23;31(9):559-567
pubmed: 30772915
Foods. 2020 Dec 26;10(1):
pubmed: 33375293
Photodermatol Photoimmunol Photomed. 2003 Aug;19(4):182-9
pubmed: 12925189
Skin Pharmacol Physiol. 2011;24(2):67-74
pubmed: 21088453
Biochim Biophys Acta. 1998 Jun 24;1372(1):135-40
pubmed: 9651505
DNA Repair (Amst). 2013 Nov;12(11):982-92
pubmed: 24075570
Free Radic Biol Med. 2012 Oct 1;53(7):1381-91
pubmed: 22889596
Am J Hum Genet. 2011 Dec 9;89(6):745-50
pubmed: 22100072
Int J Gynecol Cancer. 2011 Dec;21(9):1533-9
pubmed: 21912264
J Invest Dermatol. 1987 Jun;88(6):714-8
pubmed: 3585055
Nutr Rev. 1973 Aug;31(8):248-9
pubmed: 4586201
Langmuir. 2010 Mar 16;26(6):4168-75
pubmed: 20121267
J Dermatol Sci. 2017 Nov;88(2):159-166
pubmed: 28711237
J Clin Invest. 1994 Apr;93(4):1756-64
pubmed: 8163674
Am J Respir Cell Mol Biol. 1995 Mar;12(3):260-7
pubmed: 7873191
J Expo Sci Environ Epidemiol. 2021 Feb;31(1):137-148
pubmed: 33127990
Food Funct. 2019 Jun 19;10(6):3090-3102
pubmed: 31120074
Antioxidants (Basel). 2019 Jul 11;8(7):
pubmed: 31336715
Physiol Rev. 2018 Jul 1;98(3):1739-1763
pubmed: 29897292
FEBS Lett. 2019 Aug;593(16):2214-2225
pubmed: 31199497
J Cell Sci. 2004 Feb 15;117(Pt 5):667-75
pubmed: 14754903
Skin Res Technol. 2020 Nov;26(6):859-866
pubmed: 32585051
PLoS One. 2016 Oct 5;11(10):e0164117
pubmed: 27706261
J Surg Res. 2008 Oct;149(2):278-86
pubmed: 18619616
Biochim Biophys Acta. 1985 May 17;834(3):419-28
pubmed: 3995076
PLoS One. 2017 Feb 7;12(2):e0171178
pubmed: 28170435
Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):7707-12
pubmed: 26056268
Nat Commun. 2018 Sep 18;9(1):3624
pubmed: 30228264
Mediators Inflamm. 2010;2010:321494
pubmed: 20981292
J Invest Dermatol. 2019 Apr;139(4):760-768
pubmed: 30471252
Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Nov;1865(11):158699
pubmed: 32205211
Curr Opin Cell Biol. 1989 Dec;1(6):1107-15
pubmed: 2699799
J Invest Dermatol. 2014 Nov;134(11):2823-2832
pubmed: 24999593
Dev Cell. 2012 May 15;22(5):1079-91
pubmed: 22542839
J Biol Chem. 2005 Apr 15;280(15):14755-64
pubmed: 15671038
J Cosmet Dermatol. 2022 Jul;21(7):3022-3030
pubmed: 34668310
Part Fibre Toxicol. 2020 Jul 25;17(1):35
pubmed: 32711561
Food Chem. 2021 May 1;343:128396
pubmed: 33131949
J Biochem. 2006 Mar;139(3):543-9
pubmed: 16567419
Nutr Clin Pract. 2019 Dec;34(6):839-849
pubmed: 31697447
J Invest Dermatol. 1991 Dec;97(6):1005-12
pubmed: 1748810
J Lipid Res. 1998 Jan;39(1):186-96
pubmed: 9469597
Biochim Biophys Acta. 2016 Aug;1858(8):1926-34
pubmed: 27169629
Skin Pharmacol Physiol. 2018;31(5):262-268
pubmed: 30110701
PLoS One. 2011;6(10):e26352
pubmed: 22031828
J Virol. 2014 Aug;88(15):8479-89
pubmed: 24829345
J Am Coll Nutr. 2008 Apr;27(2):267-73
pubmed: 18689558
Gerontology. 2015;61(5):427-34
pubmed: 25660807
Nat Commun. 2017 Mar 01;8:14610
pubmed: 28248318
Jpn J Vet Res. 2005 Feb;52(4):173-84
pubmed: 15822859
Exp Dermatol. 2017 Jan;26(1):58-65
pubmed: 27315375
Br J Nutr. 2005 Jan;93(1):93-9
pubmed: 15705230
Mol Cell Biol. 2000 Feb;20(3):912-8
pubmed: 10629048
Free Radic Biol Med. 2002 Jun 15;32(12):1293-303
pubmed: 12057767
Exp Dermatol. 2009 Dec;18(12):1060-3
pubmed: 19650865
J Biol Chem. 2016 Aug 19;291(34):17772-86
pubmed: 27226631
Toxicol Appl Pharmacol. 2004 Sep 15;199(3):295-304
pubmed: 15364545
Am J Clin Nutr. 2012 Nov;96(5):1179S-84S
pubmed: 23053552
J Lipid Res. 1990 Oct;31(10):1839-44
pubmed: 2079606
Cell Transplant. 2018 May;27(5):729-738
pubmed: 29692196
Curr Probl Dermatol. 2001;29:26-42
pubmed: 11225199
J Invest Dermatol. 1999 Dec;113(6):1006-10
pubmed: 10594744