Cancer of the corpus uteri: 2021 update.
FIGO Cancer Report
chemotherapy
corpus uteri
endometrial cancer
gynecologic cancer
radiotherapy
surgery
Journal
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
ISSN: 1879-3479
Titre abrégé: Int J Gynaecol Obstet
Pays: United States
ID NLM: 0210174
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
entrez:
20
10
2021
pubmed:
21
10
2021
medline:
23
7
2022
Statut:
ppublish
Résumé
Endometrial cancer is the most common gynecological malignancy in high- and middle-income countries. Although the overall prognosis is relatively good, high-grade endometrial cancers have a tendency to recur. Recurrence needs to be prevented since the prognosis for recurrent endometrial cancer is dismal. Treatment tailored to tumor biology is the optimal strategy to balance treatment efficacy against toxicity. Since The Cancer Genome Atlas defined four molecular subgroups of endometrial cancers, the molecular factors are increasingly used to define prognosis and treatment. Standard treatment consists of hysterectomy and bilateral salpingo-oophorectomy. Lymphadenectomy (and increasingly sentinel node biopsy) enables identification of lymph node-positive patients who need adjuvant treatment, including radiotherapy and chemotherapy. Adjuvant therapy is used for Stage I-II patients with high-risk factors and Stage III patients; chemotherapy is especially used in non-endometrioid cancers and those in the copy-number high molecular group characterized by TP53 mutation. In advanced disease, a combination of surgery to no residual disease and chemotherapy with or without radiotherapy results in the best outcome. Surgery for recurrent disease is only advocated in patients with a good performance status with a relatively long disease-free interval.
Identifiants
pubmed: 34669196
doi: 10.1002/ijgo.13866
pmc: PMC9297903
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
45-60Informations de copyright
International Journal of Gynecology & Obstetrics© 2021 The Authors. International Journal of Gynecology & Obstetrics published by John Wiley & Sons Ltd on behalf of International Federation of Gynecology and Obstetrics.
Références
Front Oncol. 2021 Jan 13;10:580128
pubmed: 33520696
Am J Surg Pathol. 2018 May;42(5):561-568
pubmed: 29505428
Gynecol Oncol. 2010 Jul;118(1):14-8
pubmed: 20434198
Gynecol Oncol. 2014 Nov;135(2):190-5
pubmed: 25218303
J Clin Oncol. 2011 Mar 1;29(7):832-8
pubmed: 21263082
Cancer Imaging. 2020 Oct 22;20(1):75
pubmed: 33092631
Lancet. 2009 Jan 10;373(9658):125-36
pubmed: 19070889
Int J Radiat Oncol Biol Phys. 2021 Mar 15;109(4):975-986
pubmed: 33129910
Eur J Obstet Gynecol Reprod Biol. 1996 Apr;65(2):201-7
pubmed: 8730625
Obstet Gynecol. 1998 Mar;91(3):355-9
pubmed: 9491859
Lancet. 2010 Mar 6;375(9717):816-23
pubmed: 20206777
Int J Gynecol Cancer. 2020 Dec;30(12):2002-2007
pubmed: 33046573
Cancer. 2017 Mar 1;123(5):802-813
pubmed: 28061006
Gynecol Oncol. 2001 Oct;83(1):72-80
pubmed: 11585416
Ann Surg Oncol. 2016 Dec;23(13):4361-4367
pubmed: 27380636
Int J Gynecol Pathol. 2015 Jan;34(1):47-56
pubmed: 25473753
Br J Obstet Gynaecol. 1997 Nov;104(11):1302-7
pubmed: 9386033
Eur J Cancer. 2015 Sep;51(13):1742-50
pubmed: 26049688
J Clin Oncol. 2014 Jul 20;32(21):2277
pubmed: 24912902
J Clin Oncol. 2012 Mar 1;30(7):695-700
pubmed: 22291074
Int J Gynecol Cancer. 2001 Nov-Dec;11(6):430-7
pubmed: 11906545
J Clin Oncol. 2006 Jan 1;24(1):36-44
pubmed: 16330675
Gynecol Oncol. 2008 Jan;108(1):226-33
pubmed: 17996926
Lancet Oncol. 2019 Sep;20(9):1273-1285
pubmed: 31345626
Eur J Cancer. 2016 Sep;65:172-81
pubmed: 27501506
Gynecol Oncol. 2003 May;89(2):201-9
pubmed: 12713981
Obstet Gynecol. 2015 Feb;125(2):424-433
pubmed: 25569000
Eur J Cancer. 2013 Nov;49(16):3431-41
pubmed: 23932335
J Pathol. 2020 Mar;250(3):312-322
pubmed: 31829447
Gynecol Oncol. 2011 Nov;123(2):205-7
pubmed: 21820709
Acta Oncol. 2019 Nov;58(11):1628-1633
pubmed: 31373248
CMAJ. 1997 Oct 1;157(7):879-86
pubmed: 9327795
Lancet. 2010 Apr 3;375(9721):1165-72
pubmed: 20188410
Arch Gynecol Obstet. 2018 Sep;298(3):505-510
pubmed: 30008031
Int J Gynecol Cancer. 2008 Jul-Aug;18(4):803-8
pubmed: 17944917
Cochrane Database Syst Rev. 2018 Oct 31;10:CD006655
pubmed: 30379327
Gynecol Oncol. 2012 Jan;124(1):36-41
pubmed: 22015042
Fertil Steril. 2012 Nov;98(5):1229-35
pubmed: 22959452
Lancet. 2008 Feb 16;371(9612):569-78
pubmed: 18280327
Curr Oncol. 2019 Apr;26(2):e226-e232
pubmed: 31043831
Gynecol Oncol. 2004 Mar;92(3):744-51
pubmed: 14984936
Cancer. 1985 Jul 15;56(2):403-12
pubmed: 4005805
Best Pract Res Clin Obstet Gynaecol. 2015 Aug;29(6):845-57
pubmed: 25817745
Cancer Med. 2019 May;8(5):2013-2019
pubmed: 30848097
Gynecol Oncol. 1995 Oct;59(1):20-4
pubmed: 7557610
Eur J Cancer. 2010 Sep;46(14):2593-604
pubmed: 20843488
Recent Results Cancer Res. 2011;186:159-85
pubmed: 21113764
J Clin Oncol. 2007 May 20;25(15):2042-8
pubmed: 17513808
JAMA. 2017 Mar 28;317(12):1224-1233
pubmed: 28350928
Am J Clin Oncol. 2020 Oct;43(10):714-719
pubmed: 32804777
Gynecol Oncol. 2017 Aug;146(2):327-333
pubmed: 28511869
Cancer Res. 2006 Aug 1;66(15):7810-7
pubmed: 16885385
Gynecol Oncol. 2006 Jun;101(3):520-9
pubmed: 16556457
Br J Cancer. 2013 Oct 1;109(7):1760-5
pubmed: 24002604
Gynecol Oncol. 1994 Nov;55(2):229-33
pubmed: 7959289
Best Pract Res Clin Obstet Gynaecol. 2014 Jul;28(5):721-39
pubmed: 24852891
Gynecol Oncol. 2016 Jun;141(3):511-515
pubmed: 27103178
Eur J Obstet Gynecol Reprod Biol. 2014 Jan;172:115-9
pubmed: 24287288
IARC Sci Publ. 1997;(138):177-206
pubmed: 9353665
Br J Obstet Gynaecol. 1997 Jan;104(1):122
pubmed: 8988718
Gynecol Oncol. 2021 Jun;161(3):787-794
pubmed: 33858677
Int J Gynecol Cancer. 2013 Oct;23(8):1429-37
pubmed: 24257557
Int J Gynecol Cancer. 2010 Oct;20(7):1166-9
pubmed: 21495220
J Clin Oncol. 2018 Jul 10;36(20):2044-2051
pubmed: 29584549
Obstet Gynecol. 2017 Oct;130(4):803-813
pubmed: 28885397
Gynecol Oncol. 1995 Jan;56(1):29-33
pubmed: 7821843
Gynecol Oncol. 2017 Apr;145(1):200-207
pubmed: 28040204
Trials. 2018 Apr 16;19(1):227
pubmed: 29661218
Eur J Cancer. 2015 Jun;51(9):1164-87
pubmed: 24120180
J Clin Oncol. 2005 Jun 1;23(16):3668-75
pubmed: 15738538
Int J Gynaecol Obstet. 2019 Sep;146(3):277-288
pubmed: 31197826
Gynecol Oncol. 2014 May;133(2):192-6
pubmed: 24631453
Eur J Cancer. 2010 Sep;46(13):2422-31
pubmed: 20619634
Int J Gynecol Cancer. 2018 Mar;28(3):514-523
pubmed: 29324536
J Natl Cancer Inst. 2021 Sep 4;113(9):1212-1220
pubmed: 33693762
Ann Oncol. 2018 May 1;29(5):1180-1188
pubmed: 29432521
J Natl Cancer Inst. 2008 Dec 3;100(23):1707-16
pubmed: 19033573
J Clin Oncol. 2001 Oct 15;19(20):4048-53
pubmed: 11600606
Gynecol Oncol. 2007 Oct;107(1 Suppl 1):S241-7
pubmed: 17826824
J Clin Oncol. 2019 Jul 20;37(21):1810-1818
pubmed: 30995174
Int J Gynecol Cancer. 2011 Oct;21(7):1180-4
pubmed: 21795987
Clin Cancer Res. 2016 Aug 15;22(16):4215-24
pubmed: 27006490
Lancet. 2000 Apr 22;355(9213):1404-11
pubmed: 10791524
Gynecol Oncol. 2004 Apr;93(1):125-30
pubmed: 15047225
Lancet. 2009 Jan 10;373(9658):137-46
pubmed: 19070891
Int J Gynecol Cancer. 2011 Feb;21(2):316-22
pubmed: 21734474
Gynecol Oncol. 2017 Aug;146(2):405-415
pubmed: 28566221
Eur J Cancer. 2019 Mar;109:1-11
pubmed: 30654224
Obstet Gynecol. 2014 Aug;124(2 Pt 1):300-306
pubmed: 25004350
Int J Gynecol Cancer. 2021 Jan;31(1):12-39
pubmed: 33397713
Br J Cancer. 2006 Aug 7;95(3):266-71
pubmed: 16868539
J Natl Cancer Inst. 2013 Aug 7;105(15):1142-50
pubmed: 23781004
J Clin Oncol. 2009 Jul 20;27(21):3547-56
pubmed: 19546404
Gynecol Oncol. 2020 Sep;158(3):673-680
pubmed: 32527569
Eur J Cancer. 2016 Sep;65:185-91
pubmed: 27505629
Br J Cancer. 2009 Jul 21;101(2):244-9
pubmed: 19568245
Int J Gynecol Cancer. 2006 Sep-Oct;16(5):1746-8
pubmed: 17009965
Int J Gynaecol Obstet. 2021 Oct;155 Suppl 1:45-60
pubmed: 34669196
J Clin Oncol. 2020 Oct 10;38(29):3388-3397
pubmed: 32749941
J Clin Oncol. 2014 Jan 1;32(1):27-33
pubmed: 24276779
Int J Gynecol Cancer. 2017 Mar;27(3):493-499
pubmed: 28187090
Am J Obstet Gynecol. 2005 May;192(5):1365-7
pubmed: 15902110
J Clin Oncol. 2015 May 20;33(15):1640-6
pubmed: 25534376
CA Cancer J Clin. 2015 Mar;65(2):87-108
pubmed: 25651787
Br J Cancer. 2014 Aug 12;111(4):674-9
pubmed: 24921911
Int J Gynecol Cancer. 2021 Apr;31(4):594-604
pubmed: 33082238
Br J Cancer. 2016 Sep 6;115(6):716-24
pubmed: 27505134
Gynecol Oncol. 1996 Feb;60(2):177-83
pubmed: 8631535
Eur J Obstet Gynecol Reprod Biol. 2017 Mar;210:376-380
pubmed: 28157644
Clin Cancer Res. 2020 Aug 1;26(15):3928-3935
pubmed: 32601075
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
Arch Gynecol Obstet. 2012 May;285(5):1415-9
pubmed: 22068753
J Clin Oncol. 2020 Nov 20;38(33):3841-3850
pubmed: 33078978
Lancet Oncol. 2011 Jan;12(1):38-48
pubmed: 21147030
Int J Gynecol Cancer. 2005 May-Jun;15(3):413-9
pubmed: 15882163
Nature. 2013 May 2;497(7447):67-73
pubmed: 23636398
Clin Cancer Res. 2019 Feb 1;25(3):1087-1097
pubmed: 30413523
Eur J Surg Oncol. 2021 May;47(5):1117-1123
pubmed: 33268212
Int J Gynaecol Obstet. 2018 Oct;143 Suppl 2:51-58
pubmed: 30306577
N Engl J Med. 2019 Jun 13;380(24):2317-2326
pubmed: 31189035
J Clin Oncol. 2004 Jun 1;22(11):2159-66
pubmed: 15169803
Gynecol Obstet Invest. 2020;85(3):222-228
pubmed: 32224609
Am J Obstet Gynecol. 1995 May;172(5):1488-94
pubmed: 7755059
Br J Cancer. 2015 Jul 14;113(2):299-310
pubmed: 26172027
Gynecol Oncol. 2016 Jun;141(3):428-433
pubmed: 27001611
Cancer Epidemiol. 2013 Aug;37(4):374-7
pubmed: 23591011
JAMA Oncol. 2020 Nov 01;6(11):1766-1772
pubmed: 33001143
Am J Obstet Gynecol. 2017 May;216(5):459-476.e10
pubmed: 27871836
Anticancer Res. 2011 Sep;31(9):3047-9
pubmed: 21868557