Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine's rewarding effects but preserves natural reward processing.


Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
22 Oct 2021
Historique:
entrez: 20 10 2021
pubmed: 21 10 2021
medline: 21 10 2021
Statut: ppublish

Résumé

Addictive drugs increase dopamine in the nucleus accumbens (NAc), where it persistently shapes excitatory glutamate transmission and hijacks natural reward processing. Here, we provide evidence, from mice to humans, that an underlying mechanism relies on drug-evoked heteromerization of glutamate

Identifiants

pubmed: 34669474
doi: 10.1126/sciadv.abg5970
pmc: PMC8528421
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabg5970

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH054137
Pays : United States

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Auteurs

Andry Andrianarivelo (A)

CNRS, UMR 8246, Neuroscience Paris Seine, F-75005 Paris, France.
INSERM, UMR-S 1130, Neuroscience Paris Seine, Institute of Biology Paris Seine, F-75005 Paris, France.
Sorbonne Université, UPMC Université Paris 06, UM CR18, Neuroscience Paris Seine, F-75005 Paris, France.

Estefani Saint-Jour (E)

CNRS, UMR 8246, Neuroscience Paris Seine, F-75005 Paris, France.
INSERM, UMR-S 1130, Neuroscience Paris Seine, Institute of Biology Paris Seine, F-75005 Paris, France.
Sorbonne Université, UPMC Université Paris 06, UM CR18, Neuroscience Paris Seine, F-75005 Paris, France.

Paula Pousinha (P)

Université Côte d'Azur, Nice, France.
Institut de Pharmacologie Moléculaire et Cellulaire, CNRS UMR7275, Valbonne, France.

Sebastian P Fernandez (SP)

Université Côte d'Azur, Nice, France.
Institut de Pharmacologie Moléculaire et Cellulaire, CNRS UMR7275, Valbonne, France.

Anna Petitbon (A)

Université Bordeaux, INRAE, Bordeaux INP, NutriNeuro, 33000 Bordeaux, France.

Veronique De Smedt-Peyrusse (V)

Université Bordeaux, INRAE, Bordeaux INP, NutriNeuro, 33000 Bordeaux, France.

Nicolas Heck (N)

CNRS, UMR 8246, Neuroscience Paris Seine, F-75005 Paris, France.
INSERM, UMR-S 1130, Neuroscience Paris Seine, Institute of Biology Paris Seine, F-75005 Paris, France.
Sorbonne Université, UPMC Université Paris 06, UM CR18, Neuroscience Paris Seine, F-75005 Paris, France.

Vanesa Ortiz (V)

Université Côte d'Azur, Nice, France.
Institut de Pharmacologie Moléculaire et Cellulaire, CNRS UMR7275, Valbonne, France.

Marie-Charlotte Allichon (MC)

CNRS, UMR 8246, Neuroscience Paris Seine, F-75005 Paris, France.
INSERM, UMR-S 1130, Neuroscience Paris Seine, Institute of Biology Paris Seine, F-75005 Paris, France.
Sorbonne Université, UPMC Université Paris 06, UM CR18, Neuroscience Paris Seine, F-75005 Paris, France.

Vincent Kappès (V)

CNRS, UMR 8246, Neuroscience Paris Seine, F-75005 Paris, France.
INSERM, UMR-S 1130, Neuroscience Paris Seine, Institute of Biology Paris Seine, F-75005 Paris, France.
Sorbonne Université, UPMC Université Paris 06, UM CR18, Neuroscience Paris Seine, F-75005 Paris, France.

Sandrine Betuing (S)

CNRS, UMR 8246, Neuroscience Paris Seine, F-75005 Paris, France.
INSERM, UMR-S 1130, Neuroscience Paris Seine, Institute of Biology Paris Seine, F-75005 Paris, France.
Sorbonne Université, UPMC Université Paris 06, UM CR18, Neuroscience Paris Seine, F-75005 Paris, France.

Roman Walle (R)

Université Bordeaux, INRAE, Bordeaux INP, NutriNeuro, 33000 Bordeaux, France.

Ying Zhu (Y)

Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032, USA.
Department of Psychiatry, Columbia University, New York, NY 10032, USA.

Charlène Joséphine (C)

Commissariat à l'Énergie Atomique et aux Énergies Alternatives (CEA), Département de la Recherche Fondamentale, Institut de biologie François Jacob, MIRCen, and CNRS UMR 9199, Université Paris-Sud, Université Paris-Saclay, Neurodegenerative Diseases Laboratory, Fontenay-aux-Roses, France.

Alexis-Pierre Bemelmans (AP)

Commissariat à l'Énergie Atomique et aux Énergies Alternatives (CEA), Département de la Recherche Fondamentale, Institut de biologie François Jacob, MIRCen, and CNRS UMR 9199, Université Paris-Sud, Université Paris-Saclay, Neurodegenerative Diseases Laboratory, Fontenay-aux-Roses, France.

Gustavo Turecki (G)

Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, QC, Canada.

Naguib Mechawar (N)

Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, QC, Canada.

Jonathan A Javitch (JA)

Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032, USA.
Department of Psychiatry, Columbia University, New York, NY 10032, USA.
Department of Pharmacology, Columbia University, New York, NY 10032, USA.

Jocelyne Caboche (J)

CNRS, UMR 8246, Neuroscience Paris Seine, F-75005 Paris, France.
INSERM, UMR-S 1130, Neuroscience Paris Seine, Institute of Biology Paris Seine, F-75005 Paris, France.
Sorbonne Université, UPMC Université Paris 06, UM CR18, Neuroscience Paris Seine, F-75005 Paris, France.

Pierre Trifilieff (P)

Université Bordeaux, INRAE, Bordeaux INP, NutriNeuro, 33000 Bordeaux, France.

Jacques Barik (J)

Université Côte d'Azur, Nice, France.
Institut de Pharmacologie Moléculaire et Cellulaire, CNRS UMR7275, Valbonne, France.

Peter Vanhoutte (P)

CNRS, UMR 8246, Neuroscience Paris Seine, F-75005 Paris, France.
INSERM, UMR-S 1130, Neuroscience Paris Seine, Institute of Biology Paris Seine, F-75005 Paris, France.
Sorbonne Université, UPMC Université Paris 06, UM CR18, Neuroscience Paris Seine, F-75005 Paris, France.

Classifications MeSH