The human microbiome in immunobullous disorders and lichen planus.
Journal
Clinical and experimental dermatology
ISSN: 1365-2230
Titre abrégé: Clin Exp Dermatol
Pays: England
ID NLM: 7606847
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
revised:
05
10
2021
received:
27
05
2021
accepted:
11
10
2021
pubmed:
21
10
2021
medline:
11
3
2022
entrez:
20
10
2021
Statut:
ppublish
Résumé
For several decades, there has been a significant growth in the incidence of autoimmune diseases. Studies indicate that genetic factors may not be the only trigger for disease development and that dysbiosis of the microbiome may be another mechanism involved in the pathogenesis of autoimmune diseases. The role of the microbiome in the development of common skin disorders such as psoriasis, atopic dermatitis, acne and rosacea is increasingly well understood. However, few studies have focused on lichen planus and the rare acquired immunobullous diseases, both mucocutaneous groups of disorders linked to skin, oral and gut microbiomes. This review provides an insight into the current understanding of how the microbiome may contribute to the development of autoimmunity and to the maintenance and exacerbation of acquired immunobullous and lichenoid diseases. These mechanisms may have implications for future preventive and therapeutic approaches.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
522-528Informations de copyright
© 2021 British Association of Dermatologists.
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