Pulmonary Tumor Thrombotic Microangiopathy Due to Gastric Cancer Diagnosed Antemortem by a Cytological Examination of Aspirated Pulmonary Artery Blood.
Aged
Humans
Lung Neoplasms
/ complications
Male
Neoplastic Cells, Circulating
/ pathology
Pulmonary Artery
/ diagnostic imaging
Retrospective Studies
Stomach Neoplasms
/ complications
Thrombotic Microangiopathies
/ diagnosis
Tomography, X-Ray Computed
Vascular Endothelial Growth Factor A
/ metabolism
cardiac catheterization
gastric cancer
pulmonary tumor thrombotic microangiopathy (PTTM)
vascular endothelial growth factor (VEGF)
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
15 May 2022
15 May 2022
Historique:
pubmed:
22
10
2021
medline:
18
5
2022
entrez:
21
10
2021
Statut:
ppublish
Résumé
A 66-year-old Japanese man receiving systemic chemotherapy for advanced gastric cancer presented with exertional dyspnea. D-dimer was elevated in the blood. Echocardiography revealed pulmonary hypertension, and a ventilation-perfusion scan indicated decreased perfusion in the bilateral lungs. Cardiac catheterization showed no evidence of pulmonary artery embolization and revealed cytologically confirmed adenocarcinoma. Thus, pulmonary tumor thrombotic microangiopathy (PTTM) was diagnosed. The patient died of respiratory failure on the 17th hospitalization day despite systemic chemotherapy. Retrospective serological testing revealed increased vascular endothelial growth factor in the pulmonary artery blood. This is a rare case with antemortem cytologically proven PTTM mediated by VEGF.
Identifiants
pubmed: 34670901
doi: 10.2169/internalmedicine.8313-21
pmc: PMC9177363
doi:
Substances chimiques
Vascular Endothelial Growth Factor A
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1491-1495Références
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