Newly regenerated axons via scaffolds promote sub-lesional reorganization and motor recovery with epidural electrical stimulation.
Journal
NPJ Regenerative medicine
ISSN: 2057-3995
Titre abrégé: NPJ Regen Med
Pays: United States
ID NLM: 101699846
Informations de publication
Date de publication:
20 Oct 2021
20 Oct 2021
Historique:
received:
27
01
2021
accepted:
31
08
2021
entrez:
21
10
2021
pubmed:
22
10
2021
medline:
22
10
2021
Statut:
epublish
Résumé
Here, we report the effect of newly regenerated axons via scaffolds on reorganization of spinal circuitry and restoration of motor functions with epidural electrical stimulation (EES). Motor recovery was evaluated for 7 weeks after spinal transection and following implantation with scaffolds seeded with neurotrophin producing Schwann cell and with rapamycin microspheres. Combined treatment with scaffolds and EES-enabled stepping led to functional improvement compared to groups with scaffold or EES, although, the number of axons across scaffolds was not different between groups. Re-transection through the scaffold at week 6 reduced EES-enabled stepping, still demonstrating better performance compared to the other groups. Greater synaptic reorganization in the presence of regenerated axons was found in group with combined therapy. These findings suggest that newly regenerated axons through cell-containing scaffolds with EES-enabled motor training reorganize the sub-lesional circuitry improving motor recovery, demonstrating that neuroregenerative and neuromodulatory therapies cumulatively enhancing motor function after complete SCI.
Identifiants
pubmed: 34671050
doi: 10.1038/s41536-021-00176-6
pii: 10.1038/s41536-021-00176-6
pmc: PMC8528837
doi:
Types de publication
Journal Article
Langues
eng
Pagination
66Subventions
Organisme : Minnesota Office of Higher Education (OHE)
ID : FP00093993
Organisme : Minnesota Office of Higher Education (OHE)
ID : FP00093993
Organisme : Minnesota Office of Higher Education (OHE)
ID : FP00093993
Informations de copyright
© 2021. The Author(s).
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