Genome-wide association study of colorectal polyps identified highly overlapping polygenic architecture with colorectal cancer.
Journal
Journal of human genetics
ISSN: 1435-232X
Titre abrégé: J Hum Genet
Pays: England
ID NLM: 9808008
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
22
05
2021
accepted:
20
09
2021
revised:
04
09
2021
pubmed:
22
10
2021
medline:
5
4
2022
entrez:
21
10
2021
Statut:
ppublish
Résumé
No genome-wide association studies (GWAS) were reported for colorectal polyps and the overlap in polygenic backgrounds conferring risk of colorectal cancer and polyps remains unclear. We performed GWAS on subjects with colorectal polyps using the BioBank Japan data with 4447 cases and 157,226 controls. We evaluated genetic correlations between colorectal polyps and cancer, and effects on colorectal polyps of single nucleotide polymorphisms (SNPs) known to be associated with colorectal cancer. We identified CUX2, a known genetic locus to colorectal cancer, as a susceptibility locus to colorectal polyps (p value = 1.1 × 10
Identifiants
pubmed: 34671089
doi: 10.1038/s10038-021-00980-4
pii: 10.1038/s10038-021-00980-4
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
149-156Investigateurs
Yuji Yamanashi
(Y)
Yoichi Furukawa
(Y)
Takayuki Morisaki
(T)
Yoshinori Murakami
(Y)
Yoichiro Kamatani
(Y)
Kaori Muto
(K)
Akiko Nagai
(A)
Wataru Obara
(W)
Ken Yamaji
(K)
Kazuhisa Takahashi
(K)
Satoshi Asai
(S)
Yasuo Takahashi
(Y)
Takao Suzuki
(T)
Nobuaki Sinozaki
(N)
Hiroki Yamaguchi
(H)
Shiro Minami
(S)
Shigeo Murayama
(S)
Kozo Yoshimori
(K)
Satoshi Nagayama
(S)
Daisuke Obata
(D)
Masahiko Higashiyama
(M)
Akihide Masumoto
(A)
Yukihiro Koretsune
(Y)
Informations de copyright
© 2021. The Author(s), under exclusive licence to The Japan Society of Human Genetics.
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