Role of neutrophils, platelets, and extracellular vesicles and their interactions in COVID-19-associated thrombopathy.
COVID-19
extracellular vesicles
neutrophils
platelets
therapeutic strategy
thrombosis
Journal
Journal of thrombosis and haemostasis : JTH
ISSN: 1538-7836
Titre abrégé: J Thromb Haemost
Pays: England
ID NLM: 101170508
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
revised:
28
09
2021
received:
06
07
2021
accepted:
19
10
2021
pubmed:
22
10
2021
medline:
7
1
2022
entrez:
21
10
2021
Statut:
ppublish
Résumé
The COVID-19 pandemic extended all around the world causing millions of deaths. In addition to acute respiratory distress syndrome, many patients with severe COVID-19 develop thromboembolic complications associated to multiorgan failure and death. Here, we review evidence for the contribution of neutrophils, platelets, and extracellular vesicles (EVs) to the thromboinflammatory process in COVID-19. We discuss how the immune system, influenced by pro-inflammatory molecules, EVs, and neutrophil extracellular traps (NETs), can be caught out in patients with severe outcomes. We highlight how the deficient regulation of the innate immune system favors platelet activation and induces a vicious cycle amplifying an immunothrombogenic environment associated with platelet/NET interactions. In light of these considerations, we discuss potential therapeutic strategies underlining the modulation of purinergic signaling as an interesting target.
Identifiants
pubmed: 34672094
doi: 10.1111/jth.15566
pmc: PMC8646423
pii: S1538-7836(22)02744-1
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
17-31Informations de copyright
© 2021 International Society on Thrombosis and Haemostasis.
Références
Am J Pathol. 2018 Jan;188(1):135-148
pubmed: 29107075
Science. 2020 Sep 4;369(6508):1261-1265
pubmed: 32753553
J Immunol. 2001 Mar 1;166(5):3476-83
pubmed: 11207306
Am J Respir Cell Mol Biol. 2018 Jul;59(1):18-35
pubmed: 29553813
N Engl J Med. 2021 Apr 22;384(16):1491-1502
pubmed: 33631065
Br J Haematol. 2020 Sep;190(5):e276-e279
pubmed: 32557535
Metabolism. 2001 May;50(5):548-52
pubmed: 11319715
Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):878-882
pubmed: 33267656
Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1901-1912
pubmed: 29976772
J Extracell Vesicles. 2021 Jul;10(9):e12117
pubmed: 34262673
J Infect. 2021 May;82(5):186-230
pubmed: 33275957
Mediators Inflamm. 2020 Jul 16;2020:7527953
pubmed: 32724296
Front Biosci (Elite Ed). 2012 Jan 01;4(1):289-99
pubmed: 22201871
Blood. 2014 May 1;123(18):2768-76
pubmed: 24366358
Thromb Res. 2020 Sep;193:166-169
pubmed: 32707275
J Extracell Vesicles. 2020 Dec;10(2):e12050
pubmed: 33391636
Nat Med. 2010 Aug;16(8):887-96
pubmed: 20676107
Blood. 2020 Sep 3;136(10):1169-1179
pubmed: 32597954
Int J Mol Sci. 2017 Oct 20;18(10):
pubmed: 29053592
Lancet Haematol. 2020 Aug;7(8):e553-e555
pubmed: 32619412
Sci Rep. 2021 Apr 8;11(1):7792
pubmed: 33833254
J Am Coll Cardiol. 2020 Jul 7;76(1):122-124
pubmed: 32387623
N Engl J Med. 2020 Feb 20;382(8):727-733
pubmed: 31978945
Nat Commun. 2019 Apr 23;10(1):1916
pubmed: 31015489
Clin Chim Acta. 2020 Jul;506:145-148
pubmed: 32178975
N Engl J Med. 2021 Aug 26;385(9):790-802
pubmed: 34351721
Lancet Haematol. 2020 Aug;7(8):e575-e582
pubmed: 32619411
Arterioscler Thromb Vasc Biol. 2015 Nov;35(11):2307-15
pubmed: 26359511
N Engl J Med. 2009 Sep 10;361(11):1045-57
pubmed: 19717846
Nat Commun. 2016 Nov 15;7:13464
pubmed: 27845343
Blood. 2021 Feb 25;137(8):1061-1071
pubmed: 33512415
Circulation. 1997 Jul 1;96(1):295-301
pubmed: 9236448
JAMA Intern Med. 2021 Jan 1;181(1):41-51
pubmed: 33080002
Am J Blood Res. 2021 Feb 15;11(1):93-95
pubmed: 33796395
N Engl J Med. 2013 Mar 28;368(13):1260
pubmed: 23534573
J Clin Med. 2020 May 31;9(6):
pubmed: 32486469
Br J Pharmacol. 2020 Nov;177(21):4990-4994
pubmed: 32441783
Trends Cardiovasc Med. 2016 May;26(4):304-5
pubmed: 26850939
J Exp Med. 2020 Dec 7;217(12):
pubmed: 32926097
Am J Pathol. 1996 Nov;149(5):1617-26
pubmed: 8909251
Ann Vasc Surg. 2011 Feb;25(2):229-39
pubmed: 21131172
Eur Heart J. 2020 Jul 1;41(32):3058-3068
pubmed: 32656565
J Thromb Thrombolysis. 2014 Jan;37(1):1-3
pubmed: 24356857
Lancet Rheumatol. 2020 Aug;2(8):e457-ee458
pubmed: 32835251
J Am Coll Cardiol. 2020 Oct 20;76(16):1815-1826
pubmed: 32860872
Clin Chem Lab Med. 2020 Oct 29;59(2):e53-e55
pubmed: 33112778
JACC Basic Transl Sci. 2018 Aug 28;3(4):435-449
pubmed: 30175268
Blood. 2013 Oct 17;122(16):2784-94
pubmed: 24009232
Med Hypotheses. 2020 Oct;143:110051
pubmed: 32650197
Am J Respir Crit Care Med. 2020 Jan 1;201(1):33-46
pubmed: 31498653
Cell. 2019 Jan 10;176(1-2):113-126.e15
pubmed: 30633902
Circ Res. 2020 Sep 17;:
pubmed: 32938299
Am J Pathol. 1986 Sep;124(3):367-72
pubmed: 3532812
J Am Soc Nephrol. 2002 Dec;13(12):2840-9
pubmed: 12444202
Curr Opin Hematol. 2000 Sep;7(5):273-7
pubmed: 10961576
J Thromb Haemost. 2020 Apr;18(4):844-847
pubmed: 32073213
Blood Adv. 2021 Feb 9;5(3):628-634
pubmed: 33560376
J Exp Med. 2012 Apr 9;209(4):819-35
pubmed: 22451716
JCI Insight. 2020 Jul 23;5(14):
pubmed: 32530438
Eur Heart J. 2020 Sep 1;41(32):3038-3044
pubmed: 32882706
Nature. 2017 Apr 6;544(7648):105-109
pubmed: 28329764
Thromb Haemost. 2017 Jun 28;117(7):1296-1316
pubmed: 28569921
Trends Pharmacol Sci. 2007 Sep;28(9):465-72
pubmed: 17692395
J Biomed Sci. 2021 Jun 11;28(1):46
pubmed: 34116654
Cell Rep. 2020 May 12;31(6):107615
pubmed: 32402278
Immunology. 2009 Sep;128(1 Suppl):e181-92
pubmed: 19740307
J Exp Med. 2020 Dec 7;217(12):
pubmed: 32926098
Int J Mol Sci. 2020 Jun 30;21(13):
pubmed: 32629995
Platelets. 2015;26(2):119-26
pubmed: 24617442
Circ Res. 2011 May 13;108(10):1284-97
pubmed: 21566224
Lancet Rheumatol. 2020 Jul;2(7):e437-e445
pubmed: 32835247
N Engl J Med. 2005 Oct 20;353(16):1711-23
pubmed: 16236742
Semin Immunopathol. 2011 Sep;33(5):469-86
pubmed: 21866419
JAMA Intern Med. 2013 May 13;173(9):743-52
pubmed: 23546607
J Clin Invest. 2020 Nov 2;130(11):5674-5676
pubmed: 32925166
Thromb Res. 2020 Sep;193:110-115
pubmed: 32535232
JACC Basic Transl Sci. 2021 Mar;6(3):202-218
pubmed: 33649738
J Thromb Haemost. 2020 May;18(5):1023-1026
pubmed: 32338827
Lancet Respir Med. 2021 Aug;9(8):924-932
pubmed: 34051877
Nat Commun. 2021 Apr 23;12(1):2417
pubmed: 33893295
J Clin Invest. 2019 Apr 16;129(7):2872-2877
pubmed: 30990798
J Clin Invest. 2015 Dec;125(12):4638-54
pubmed: 26551681
ACR Open Rheumatol. 2020 May;2(5):276-282
pubmed: 32267081
J Immunol. 2008 Aug 1;181(3):2189-95
pubmed: 18641358
Res Pract Thromb Haemost. 2019 Oct 17;4(1):23-35
pubmed: 31989082
J Thromb Thrombolysis. 2021 Feb;51(2):446-453
pubmed: 33151461
Blood. 2020 Sep 10;136(11):1330-1341
pubmed: 32678428
Am J Pathol. 2018 Jul;188(7):1625-1639
pubmed: 29684360
PLoS One. 2021 Feb 22;16(2):e0246806
pubmed: 33617530
Crit Care. 2011;15(6):R289
pubmed: 22129171
J Inflamm Res. 2020 Dec 14;13:1113-1124
pubmed: 33363395
Thromb Res. 2018 Oct;170:87-96
pubmed: 30138777
J Clin Invest. 2020 Nov 2;130(11):6151-6157
pubmed: 32759504
Clin Infect Dis. 2021 Jul 15;73(2):e445-e454
pubmed: 32651997
Inflammation. 2019 Feb;42(1):290-305
pubmed: 30218321
Curr Atheroscler Rep. 2014 Jul;16(7):425
pubmed: 24838375
Intensive Care Med. 2020 Jun;46(6):1089-1098
pubmed: 32367170
Thromb Haemost. 2015 Aug 31;114(3):490-7
pubmed: 26156883
J Hypertens. 2018 Jun;36(6):1360-1371
pubmed: 29470366
J Clin Pharm Ther. 2020 Dec;45(6):1515-1519
pubmed: 32860252
Crit Care. 2020 Jun 5;24(1):290
pubmed: 32503680
N Engl J Med. 2020 Dec 10;383(24):2333-2344
pubmed: 33085857
N Engl J Med. 2021 Aug 26;385(9):777-789
pubmed: 34351722
J Hematol Oncol. 2020 Sep 4;13(1):120
pubmed: 32887634
J Leukoc Biol. 2021 Jan;109(1):35-47
pubmed: 33242368
PLoS One. 2016 Feb 24;11(2):e0149775
pubmed: 26909757
J Clin Invest. 2003 Nov;112(10):1589-96
pubmed: 14617760
J Virol. 2002 Feb;76(3):1071-6
pubmed: 11773383
Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13076-81
pubmed: 22826226
Blood. 2020 Sep 10;136(11):1317-1329
pubmed: 32573711
Crit Care. 2020 Jun 8;24(1):311
pubmed: 32513225
Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):2638-2650
pubmed: 30354252
J Cell Biol. 2009 Jan 26;184(2):205-13
pubmed: 19153223
J Thromb Haemost. 2020 May;18(5):1009-1019
pubmed: 32020753
Thromb Haemost. 2020 Aug;120(8):1230-1232
pubmed: 32349132
Nat Med. 2007 Apr;13(4):463-9
pubmed: 17384648
J Thromb Haemost. 2013 Oct;11(10):1867-76
pubmed: 23890048
Blood. 1993 Oct 15;82(8):2371-8
pubmed: 8400288
Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2594-604
pubmed: 16990554
PLoS One. 2021 Feb 11;16(2):e0246825
pubmed: 33571280
Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt B):2901-2912
pubmed: 29864522
J Cell Mol Med. 2020 Jul;24(13):7266-7281
pubmed: 32520423
Blood. 2012 Jun 28;119(26):6335-43
pubmed: 22596262
Platelets. 2018 Nov;29(7):677-685
pubmed: 29461910
J Biol Regul Homeost Agents. 2020 Aug 03;34(5):1623-1627
pubmed: 32744052
EClinicalMedicine. 2020 Nov;28:100590
pubmed: 33173853
Platelets. 2021 Feb 17;32(2):284-287
pubmed: 33349108
Circulation. 2020 Nov 3;142(18):1787-1790
pubmed: 32946302
Curr Opin Hematol. 2017 Jan;24(1):23-31
pubmed: 27820736
FASEB J. 2007 Jun;21(8):1926-33
pubmed: 17314141
Arterioscler Thromb Vasc Biol. 2020 Dec;40(12):2975-2989
pubmed: 33052054
Eur Heart J. 2015 Jun 7;36(22):1405-14
pubmed: 25660055
Atherosclerosis. 2009 Jun;204(2):636-41
pubmed: 19091315
Am J Pathol. 2013 Jul;183(1):173-81
pubmed: 23673000
J Thromb Haemost. 2020 Mar;18(3):609-623
pubmed: 31833175
Thromb Res. 2020 Jul;191:145-147
pubmed: 32291094
Front Immunol. 2017 Aug 07;8:928
pubmed: 28824648
Platelets. 2014;25(7):517-25
pubmed: 24127651
Int Immunopharmacol. 2020 Jul;84:106504
pubmed: 32304994
JAMA Cardiol. 2020 Dec 29;:
pubmed: 33372956
Ann Rheum Dis. 2014 Oct;73(10):1854-63
pubmed: 23873874
Am J Hypertens. 2021 Apr 2;34(3):282-290
pubmed: 33386395
Front Microbiol. 2019 May 10;10:1057
pubmed: 31134045
Br J Haematol. 2002 Jan;116(1):173-7
pubmed: 11841414
Nat Rev Cardiol. 2021 Mar;18(3):194-209
pubmed: 33214651
Sci Rep. 2018 Mar 5;8(1):4020
pubmed: 29507382
Cell. 2020 Nov 12;183(4):982-995.e14
pubmed: 32991843
Eur Rev Med Pharmacol Sci. 2017 Apr;21(7):1695-1701
pubmed: 28429334
JCI Insight. 2020 Jun 4;5(11):
pubmed: 32329756
Am J Hematol. 2021 Apr 1;96(4):471-479
pubmed: 33476420
Cell Biol Int. 2021 Apr;45(4):702-707
pubmed: 33289192
Exp Biol Med (Maywood). 2021 Mar;246(6):688-694
pubmed: 33302737
Crit Care. 2020 Jul 17;24(1):444
pubmed: 32680535
J Thromb Haemost. 2017 Jul;15(7):1285-1294
pubmed: 28671350
Sci Rep. 2020 Nov 12;10(1):19630
pubmed: 33184506
Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):1777-83
pubmed: 22652600
Front Immunol. 2020 Jun 23;11:1518
pubmed: 32655582
Acta Pharm Sin B. 2020 Jul;10(7):1205-1215
pubmed: 32318327
Cold Spring Harb Perspect Biol. 2012 Feb 01;4(2):
pubmed: 21937733
Biomaterials. 2021 Jan;267:120389
pubmed: 33130319
Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):186-199
pubmed: 32998520
PLoS One. 2012;7(9):e44606
pubmed: 22984532
EBioMedicine. 2020 Aug;58:102925
pubmed: 32745993
Clin Immunol. 2020 Nov;220:108598
pubmed: 32961333
Thromb Res. 2015 Mar;135(3):497-501
pubmed: 25575413
J Thromb Haemost. 2020 Jul;18(7):1738-1742
pubmed: 32302438
Front Med (Lausanne). 2018 Apr 30;5:121
pubmed: 29761104
Arterioscler Thromb Vasc Biol. 2019 Sep;39(9):1724-1738
pubmed: 31315434
SN Compr Clin Med. 2020;2(11):2048-2058
pubmed: 32984764
PLoS Biol. 2021 Feb 17;19(2):e3001109
pubmed: 33596198
Br J Pharmacol. 2020 Nov;177(21):4971-4974
pubmed: 32639031
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Front Immunol. 2019 Jul 17;10:1687
pubmed: 31379873
Front Pharmacol. 2020 Nov 26;11:594487
pubmed: 33324223
Cytokine Growth Factor Rev. 2020 Aug;54:62-75
pubmed: 32513566
Thromb Res. 2020 Oct;194:36-41
pubmed: 32569879
Br J Pharmacol. 2019 Sep;176(17):3350-3363
pubmed: 31206609
J Exp Med. 2020 Jun 1;217(6):
pubmed: 32302401
Immunol Lett. 2005 Jan 31;96(2):203-10
pubmed: 15585324
Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15880-5
pubmed: 20798043
Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):988-994
pubmed: 33267662
Science. 2020 Aug 7;369(6504):718-724
pubmed: 32661059
Cardiovasc Res. 2020 Aug 1;116(10):1666-1687
pubmed: 32352535
J Thromb Haemost. 2020 Nov;18(11):3067-3073
pubmed: 32945081
Am J Respir Crit Care Med. 2020 Jun 1;201(11):1372-1379
pubmed: 32242738
Proc Natl Acad Sci U S A. 2017 May 2;114(18):4763-4768
pubmed: 28420787
J Clin Med. 2020 Oct 28;9(11):
pubmed: 33126772
Clin Exp Immunol. 2001 Dec;126(3):584-8
pubmed: 11737080
EBioMedicine. 2020 Mar;53:102671
pubmed: 32114386
J Biol Regul Homeost Agents. 2013 Jul-Sep;27(3):841-52
pubmed: 24152848