DoE Optimization Empowers the Automated Preparation of Enantiomerically Pure [

Animals Antineoplastic Agents / chemistry Automation Breast Neoplasms / drug therapy Cell Proliferation / drug effects Drug Screening Assays, Antitumor Female Fluorine Radioisotopes Humans Mammary Neoplasms, Experimental / drug therapy Mice, Inbred NOD Molecular Structure Phthalazines / chemistry Poly(ADP-ribose) Polymerase Inhibitors / chemistry Poly(ADP-ribose) Polymerases / analysis Tumor Cells, Cultured

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
11 11 2021
Historique:
pubmed: 22 10 2021
medline: 15 12 2021
entrez: 21 10 2021
Statut: ppublish

Résumé

Given the clinical potential of poly(ADP-ribose) polymerases (PARP) imaging for the detection and stratification of various cancers, the development of novel PARP imaging probes with improved pharmacological profiles over established PARP imaging agents is warranted. Here, we present a novel

Identifiants

DOI: 10.1021/acs.jmedchem.1c00903 PMID: 34672571
pubmed: 34672571
doi: 10.1021/acs.jmedchem.1c00903
doi:

Substances chimiques

Antineoplastic Agents 0
Fluorine Radioisotopes 0
Phthalazines 0
Poly(ADP-ribose) Polymerase Inhibitors 0
talazoparib 9QHX048FRV
Poly(ADP-ribose) Polymerases EC 2.4.2.30
Fluorine-18 GZ5I74KB8G

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

15690-15701

Auteurs

Gregory D Bowden (GD)

Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University, Roentgenweg 15, 72076 Tuebingen, Germany.
Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", Eberhard Karls University, Roentgenweg 13, 72076 Tuebingen, Germany.
ORCID: 0000-0003-2274-6738

Sophie Stotz (S)

Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University, Roentgenweg 15, 72076 Tuebingen, Germany.
Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", Eberhard Karls University, Roentgenweg 13, 72076 Tuebingen, Germany.
ORCID: 0000-0003-4020-1088

Johannes Kinzler (J)

Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University, Roentgenweg 15, 72076 Tuebingen, Germany.

Christian Geibel (C)

Institute of Pharmaceutical Sciences, Department of Pharmaceutical (Bio-)Analysis, Eberhard Karls University, Auf der Morgenstelle 8, 72076 Tuebingen, Germany.

Michael Lämmerhofer (M)

Institute of Pharmaceutical Sciences, Department of Pharmaceutical (Bio-)Analysis, Eberhard Karls University, Auf der Morgenstelle 8, 72076 Tuebingen, Germany.
ORCID: 0000-0002-1318-0974

Bernd J Pichler (BJ)

Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University, Roentgenweg 15, 72076 Tuebingen, Germany.
Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", Eberhard Karls University, Roentgenweg 13, 72076 Tuebingen, Germany.
German Cancer Research Center, German Cancer Consortium DKTK, Partner Site Tuebingen, Roentgenweg 13, 72076 Tuebingen, Germany.

Andreas Maurer (A)

Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University, Roentgenweg 15, 72076 Tuebingen, Germany.
Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", Eberhard Karls University, Roentgenweg 13, 72076 Tuebingen, Germany.
ORCID: 0000-0003-2412-5361

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › DoE Optimization Empowers the Automated...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › DoE Optimization Empowers the Automated...
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Automatisation › DoE Optimization Empowers the Automated...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › DoE Optimization Empowers the Automated...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › DoE Optimization Empowers the Automated...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de criblage d'agents antitumoraux › DoE Optimization Empowers the Automated...
questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Radio-isotopes › Radio-isotopes du fluor › DoE Optimization Empowers the Automated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › DoE Optimization Empowers the Automated...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Tumeurs expérimentales › Tumeurs expérimentales de la mamelle › DoE Optimization Empowers the Automated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée NOD › DoE Optimization Empowers the Automated...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › DoE Optimization Empowers the Automated...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridazines › Phtalazines › DoE Optimization Empowers the Automated...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Inhibiteurs de poly(ADP-ribose) polymérases › DoE Optimization Empowers the Automated...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Pentosyltransferases › ADP ribose transferases › Poly(ADP-ribose) polymerases › DoE Optimization Empowers the Automated...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › DoE Optimization Empowers the Automated...