An integrated approach to investigate age-related modifications of morphological, mechanical and structural properties of type I collagen.
AGEs
Aging
Mechanical properties
Raman spectroscopy
SHG
Type I collagen
Journal
Acta biomaterialia
ISSN: 1878-7568
Titre abrégé: Acta Biomater
Pays: England
ID NLM: 101233144
Informations de publication
Date de publication:
01 01 2022
01 01 2022
Historique:
received:
11
04
2021
revised:
08
10
2021
accepted:
12
10
2021
pubmed:
22
10
2021
medline:
27
1
2022
entrez:
21
10
2021
Statut:
ppublish
Résumé
The main propose of this study is to characterize the impact of chronological aging on mechanical, structural, biochemical, and morphological properties of type I collagen. We have developed an original approach combining a stress-strain measurement device with a portable Raman spectrometer to enable simultaneous measurement of Raman spectra during stress vs strain responses of young adult, adult and old rat tail tendon fascicles (RTTFs). Our data showed an increase in all mechanical properties such as Young's modulus, yield strength, and ultimate tensile strength with aging. At the molecular level, Raman data revealed that the most relevant frequency shift was observed at 938 cm
Identifiants
pubmed: 34673231
pii: S1742-7061(21)00688-7
doi: 10.1016/j.actbio.2021.10.020
pii:
doi:
Substances chimiques
Collagen Type I
0
Collagen
9007-34-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
64-78Informations de copyright
Copyright © 2021 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare no conflict of interest