Protocol for a systematic review of the diagnostic test accuracy of tests for IgE-mediated food allergy.
IgE-mediated
basophil activation test
component-resolved diagnostics
diagnosis
diagnostic tests
food allergy
mast cell activation test
skin prick test
specific IgE
Journal
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
ISSN: 1399-3038
Titre abrégé: Pediatr Allergy Immunol
Pays: England
ID NLM: 9106718
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
revised:
06
09
2021
received:
14
07
2021
accepted:
09
09
2021
pubmed:
22
10
2021
medline:
18
3
2022
entrez:
21
10
2021
Statut:
ppublish
Résumé
The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of updating the guidelines on the diagnosis and management of food allergy. The existing guidelines are based on a systematic review of the literature until 30 September 2012. Therefore, a new systematic review must be undertaken to inform the new guidelines. This systematic review aims to assess the accuracy of index tests to support the diagnosis of IgE-mediated food allergy. The databases Cochrane CENTRAL (Trials), MEDLINE (OVID) and Embase (OVID) will be searched for diagnostic test accuracy studies from 1 October 2012 to 30 June 2021. Inclusion and exclusion criteria will be used to select appropriate studies. Data from these studies will be extracted and tabulated, and then reviewed for risk of bias and applicability using the QUADAS-2 tool. All evaluations will be done in duplicate. Studies with a high risk of bias and low applicability will be excluded. Meta-analysis will be performed if there are three or more studies of the same index test and food. A protocol for the systematic review and meta-analyses is presented and was registered using Prospero prior to commencing the literature search. Oral food challenges are the reference standard for diagnosis but involve considerable risks and resources. This protocol for systematic review aims to assess the accuracy of various tests to diagnose food allergy, which can be useful in both clinical and research settings.
Sections du résumé
BACKGROUND
The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of updating the guidelines on the diagnosis and management of food allergy. The existing guidelines are based on a systematic review of the literature until 30 September 2012. Therefore, a new systematic review must be undertaken to inform the new guidelines. This systematic review aims to assess the accuracy of index tests to support the diagnosis of IgE-mediated food allergy.
METHODS
The databases Cochrane CENTRAL (Trials), MEDLINE (OVID) and Embase (OVID) will be searched for diagnostic test accuracy studies from 1 October 2012 to 30 June 2021. Inclusion and exclusion criteria will be used to select appropriate studies. Data from these studies will be extracted and tabulated, and then reviewed for risk of bias and applicability using the QUADAS-2 tool. All evaluations will be done in duplicate. Studies with a high risk of bias and low applicability will be excluded. Meta-analysis will be performed if there are three or more studies of the same index test and food.
RESULTS
A protocol for the systematic review and meta-analyses is presented and was registered using Prospero prior to commencing the literature search.
DISCUSSION
Oral food challenges are the reference standard for diagnosis but involve considerable risks and resources. This protocol for systematic review aims to assess the accuracy of various tests to diagnose food allergy, which can be useful in both clinical and research settings.
Substances chimiques
Allergens
0
Immunoglobulin E
37341-29-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13684Subventions
Organisme : Medical Research Council
ID : G0902018
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M008517/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/T032081/1
Pays : United Kingdom
Investigateurs
Cezmi A Akdis
(CA)
Alberto Alvarez-Perea
(A)
Montserrat Alvaro Lozano
(MA)
Riccardo Asero
(R)
Barbara Ballmer-Weber
(B)
Domingo Barber
(D)
Simona Barni
(S)
Giovanni Battista Pajno
(GB)
Kirsten Beyer
(K)
Carsten Bindslev-Jensen
(C)
Helen Brough
(H)
Betul Buyuktiryaki
(B)
Lucila Camargo Lopes de Oliveira
(LCL)
Antonella Cianferoni
(A)
R Sharon Chinthrajah
(RS)
Sean N Parker
(SN)
Stefano Del Giacco
(SD)
Audrey DunnGalvin
(A)
Bernadette Eberlein
(B)
Motohiro Ebisawa
(M)
Philippe Eigenmann
(P)
Thomas Eiwegger
(T)
Margaretha Faber
(M)
Montserrat Fernandez-Rivas
(M)
Mary Feeney
(M)
Helen Fisher
(H)
Mattia Giovannini
(M)
Susanne Halken
(S)
Karin Hoffmann-Sommergruber
(K)
Hannah Jaumdally
(H)
Christina J Jones
(CJ)
Rebecca Knibb
(R)
Edward Knol
(E)
George N Konstantinou
(GN)
Marta Krawiec
(M)
Susanne Lau
(S)
Lina Mayorga
(L)
M Andreina Marques-Mejias
(MA)
Rosan Meyer
(R)
Beatriz Moya
(B)
Charlotte G Mortz
(CG)
Antonella Muraro
(A)
Kari Nadeau
(K)
N Parker
(N)
Caroline Nilsson
(C)
Liam O'Mahony
(L)
Nikolaos G Papadopoulos
(NG)
Kirsten Perrett
(K)
Alexandre Piletta-Zanin
(A)
Marcia Podestà
(M)
Lars K Poulsen
(LK)
Cristian Ricci
(C)
Graham Roberts
(G)
Hugh Sampson
(H)
Sylwia Smolińska
(S)
Jürgen Schwarze
(J)
Eva Untersmayr
(E)
Ronald Van Ree
(RV)
Carina Venter
(C)
Brian P Vickery
(BP)
Berber Vlieg-Boerstra
(B)
Informations de copyright
© 2021 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
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