Exposure to inorganic particles in paediatric sarcoidosis: the PEDIASARC study.

Adult Child Dust Environmental Exposure / adverse effects Humans Occupational Exposure / adverse effects Occupations Sarcoidosis Talc
occupational lung disease paediatric interstitial lung disease rare lung diseases sarcoidosis

Journal

Thorax
ISSN: 1468-3296
Titre abrégé: Thorax
Pays: England
ID NLM: 0417353

Informations de publication

Date de publication:
04 2022
Historique:
received: 26 06 2021
accepted: 25 09 2021
pubmed: 23 10 2021
medline: 25 3 2022
entrez: 22 10 2021
Statut: ppublish

Résumé

Inorganic antigens may contribute to paediatric sarcoidosis. Thirty-six patients matched with 36 healthy controls as well as a group of 21 sickle-cell disease (SCD) controls answered an environmental questionnaire. Patients' indirect exposure to inorganic particles, through coresidents' occupations, was higher than in healthy and SCD controls (median score: 2.5 (0.5-7) vs 0.5 (0-2), p=0.003 and 1 (0-2), p=0.012, respectively), especially for construction, exposures to metal dust, talc, abrasive reagents and scouring products. Wood or fossil energies heating were also linked to paediatric sarcoidosis. This study supports a link between mineral environmental exposure due to adult coresident occupations and paediatric sarcoidosis.

Identifiants

DOI: 10.1136/thoraxjnl-2021-217870 PMID: 34675126
pubmed: 34675126
pii: thoraxjnl-2021-217870
doi: 10.1136/thoraxjnl-2021-217870
doi:

Substances chimiques

Dust 0
Talc 14807-96-6

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

404-407

Commentaires et corrections

Type : CommentIn

Informations de copyright

© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: None declared.

Auteurs

Nadia Nathan (N)

Pediatric Pulmonology Department and Reference Center for Rare Lung Diseases RespiRare, Inserm UMR_S933 Laboratory of Childhood Genetic Diseases, Armand Trousseau Hospital, AP-HP. Sorbonne Université, Paris, France nadia.nathan@aphp.fr.
ORCID: 0000-0001-5149-7975

Marie-Emeline Montagne (ME)

Pediatric Pulmonology Department and Reference Center for Rare Lung Diseases RespiRare, Armand Trousseau Hospital, AP-HP. Sorbonne Université, Paris, France.

Odile Macchi (O)

Observatoire, Samu Social de Paris, Paris, France.

Paul-André Rosental (PA)

Centre d'Histoire, Sciences Po, Paris, France.

Simon Chauveau (S)

Pulmonology Department and Inserm UMR 127, Avicenne Hospital, APHP. Université Sorbonne Paris Nord, Paris, France.

Florence Jeny (F)

Pulmonology Department and Inserm UMR 127, Avicenne Hospital, APHP. Université Sorbonne Paris Nord, Paris, France.

Lucile Sesé (L)

Pulmonology Department and Inserm UMR 127, Avicenne Hospital, APHP. Université Sorbonne Paris Nord, Paris, France.

Rola Abou Taam (R)

Pediatric Pulmonology Department and Reference Center for Rare Lung Diseases RespiRare, Necker Enfants Malades Hospital, AP-HP. Centre - Université de Paris, Paris, France.

Manon Brocvielle (M)

Statistician, Marcq-en-Baroeul, France.

Jacques Brouard (J)

Pediatric Pulmonology Department, CHU Caen, Caen, France.

Mickaël Catinon (M)

MINAPATH : SAS sociale et solidaire, Lyon, France.

Catherine Chapelon-Abric (C)

Department of Internal Medicine and Clinical Immunology, La Pitié-Salpêtrière Hospital, APHP. Sorbonne Université, Paris, France.

Fleur Cohen-Aubart (F)

Department of Internal Medicine 2, La Pitié-Salpêtrière Hospital, e3m Institute, Reference Center for Rare Systemic Diseases, Lupus, Anti-Phospholipids Syndrome, AP-HP. Sorbonne Université, Paris, France.

Christophe Delacourt (C)

Pediatric Pulmonology Department and Reference Center for Rare Lung Diseases RespiRare, Necker Enfants Malades Hospital, AP-HP. Centre - Université de Paris, Paris, France.

Céline Delestrain (C)

Pediatric Department and Reference Center for Rare Lung Diseases RespiRare, INSERM, IMRB, Centre Hospitalier Intercommunal de Créteil, Université Paris Est Creteil, Paris, France.

Antoine Deschildre (A)

Pediatric pulmonology and allergy department, Hôpital Jeanne de Flandre, Université de Lille, Lille, France.

Antoine Dossier (A)

Department of Internal Medicine, Bichat Hospital, AP-HP. Nord - Université de Paris, Paris, France.

Ralph Epaud (R)

Centre Hospitalier Intercommunal de Créteil, Pediatric Department and Reference center for rare lung diseases (RespiRare), INSERM, IMRB, Université Paris Est Creteil, Paris, France.
ORCID: 0000-0003-3830-1039

Julien Haroche (J)

Department of Internal Medicine 2, La Pitié-Salpêtrière Hospital, e3m Institute, Reference Center for Rare Systemic Diseases, Lupus, Anti-Phospholipids Syndrome, AP-HP. Sorbonne Université, Paris, France.

Véronique Houdouin (V)

Pediatric Pulmonology department, Robert Debré Hospital, AP-HP. Nord - Université de Paris, Paris, France.

Dominique Israel-Biet (D)

Pulmonology department, Georges Pompidou Hospital, AP-HP. Centre - Université de Paris, Paris, France.

Karine Juvin (K)

Pulmonology department, Georges Pompidou Hospital, AP-HP. Centre - Université de Paris, Paris, France.

Sylvain Le Jeune (S)

Department of Internal Medicine, Avicenne Hospital, APHP. Université Sorbonne Paris Nord, Paris, France.

Francois Lionnet (F)

Department of Internal Medicine, Tenon Hospital, AP-HP. Sorbonne Université, Paris, France.

Ulrich Meinzer (U)

Department of General Pediatrics, Pediatric Internal Medicine, Rheumatology and Infectious Diseases, National Referee Center for Rare Pediatric Inflammatory Rheumatisms and Systemic Auto-Immune Diseases RAISE, Robert Debré Hospital, AP-HP. Nord - Université de Paris, Paris, France.

Marie Mittaine (M)

Pediatric Pulmonology Department, Children Hospital, CHU Toulouse, Toulouse, France.

Hilario Nunes (H)

Pulmonology Department and Inserm UMR 127, Avicenne Hospital, APHP. Université Sorbonne Paris Nord, Paris, France.

Sarah Mattioni (S)

Department of Internal Medicine, Tenon Hospital, AP-HP. Sorbonne Université, Paris, France.

Jean-Marc Naccache (JM)

Pulmonology Department, Groupe hospitalier Paris Saint-Joseph and Hôpital Foch, Paris, France.

Marie-Hélène Odièvre (MH)

Department of Pediatrics and Sickle Cell Disease Center, Armand Trousseau Hospital, AP-HP. Sorbonne Université, Paris, France.

Michel Vincent (M)

MINAPATH : SAS sociale et solidaire, Lyon, France.

Annick Clement (A)

Pediatric Pulmonology Department and Reference Center for Rare Lung Diseases RespiRare, Inserm UMR_S933 Laboratory of Childhood Genetic Diseases, Armand Trousseau Hospital, AP-HP. Sorbonne Université, Paris, France.

Dominique Valeyre (D)

Pulmonology Department and Inserm UMR 127, Avicenne Hospital, APHP. Université Sorbonne Paris Nord, Paris, France.
Pulmonology department, Paris Saint Joseph Hospital Group, Paris, France.

Catherine Cavalin (C)

Institut de recherche interdisciplinaire en sciences sociales (IRISSO, UMR CNRS-INRA 7170-1427), Université Paris Dauphine, PSL, Paris, France.
Laboratoire interdisciplinaire d'évaluation des politiques publiques (LIEPP), Sciences Po, Paris, France.
Centre d'études de l'emploi et du travail (CEET, CNAM), CNAM, Paris, France.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Exposure to inorganic particles in paediatric...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Exposure to inorganic particles in paediatric...
questionsmedicales.fr › Mélanges complexes › Matière particulaire › Poussière › Exposure to inorganic particles in paediatric...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Exposition environnementale › Exposure to inorganic particles in paediatric...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Exposure to inorganic particles in paediatric...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Exposition environnementale › Exposition professionnelle › Exposure to inorganic particles in paediatric...
questionsmedicales.fr › Caractéristiques de la population › Facteurs socioéconomiques › Professions › Exposure to inorganic particles in paediatric...
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité retardée › Sarcoïdose › Exposure to inorganic particles in paediatric...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du silicium › Silice › Acide silicique › Silicates › Silicates de magnésium › Talc › Exposure to inorganic particles in paediatric...