The SARS-CoV-2 main protease M

Animals Blood-Brain Barrier / metabolism Brain / metabolism Chlorocebus aethiops Coronavirus 3C Proteases / genetics Cricetinae Female Humans Intracellular Signaling Peptides and Proteins / genetics Male Mesocricetus Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Microvessels / metabolism SARS-CoV-2 / genetics Vero Cells

Journal

Nature neuroscience

ISSN: 1546-1726

Titre abrégé: Nat Neurosci

Pays: United States

ID NLM: 9809671

Informations de publication

Date de publication:
11 2021

Historique:

received: 12 11 2020

accepted: 24 08 2021

pubmed: 23 10 2021

medline: 9 11 2021

entrez: 22 10 2021

Statut: ppublish

Résumé

Coronavirus disease 2019 (COVID-19) can damage cerebral small vessels and cause neurological symptoms. Here we describe structural changes in cerebral small vessels of patients with COVID-19 and elucidate potential mechanisms underlying the vascular pathology. In brains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected individuals and animal models, we found an increased number of empty basement membrane tubes, so-called string vessels representing remnants of lost capillaries. We obtained evidence that brain endothelial cells are infected and that the main protease of SARS-CoV-2 (M

Identifiants

DOI: 10.1038/s41593-021-00926-1 PMID: 34675436 PMC: PMC8553622

pubmed: 34675436

doi: 10.1038/s41593-021-00926-1

pii: 10.1038/s41593-021-00926-1

pmc: PMC8553622

mid: EMS133510

doi:

Substances chimiques

Intracellular Signaling Peptides and Proteins 0

NEMO protein, mouse 0

Coronavirus 3C Proteases EC 3.4.22.28

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

1522-1533

Subventions

Organisme : European Research Council

ID : 810331

Pays : International

Informations de copyright

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