Comparison of SOX-10, HMB-45, and Melan-A in Benign Melanocytic Lesions.
atypical junctional melanocytic hyperplasia
benign melanocytic lesion
immunohistochemical stains
lentigo
melanocytes
Journal
Clinical, cosmetic and investigational dermatology
ISSN: 1178-7015
Titre abrégé: Clin Cosmet Investig Dermatol
Pays: New Zealand
ID NLM: 101543449
Informations de publication
Date de publication:
2021
2021
Historique:
received:
12
08
2021
accepted:
28
09
2021
entrez:
22
10
2021
pubmed:
23
10
2021
medline:
23
10
2021
Statut:
epublish
Résumé
Different immunohistochemical stains are used in dermatopathology to stain melanocytes and diagnose benign and malignant melanocytic lesions. SOX-10, HMB-45, and Melan-A immunohistochemical stains were used to assess 32 biopsy specimens with a histologic diagnosis of lentigo. The total number of melanocytes stained with each immunohistochemical stain was counted and an average count was obtained from two readings. Analysis of the data revealed a significant difference in staining melanocytes between these three immunostains (p=0.0010, ANOVA). SOX-10 stained 0.195 more melanocytes than HMB-45 (p=0.0026). Similarly, Melan-A stained 0.195 more melanocytes than HMB-45 (p=0.0011). However, the difference between SOX-10 and Melan-A was not statistically significant (p=0.9810). SOX-10 and Melan-A immunostaining stain more melanocytes than HMB-45. No significant difference was noted between Melan-A and SOX-10.
Identifiants
pubmed: 34675577
doi: 10.2147/CCID.S333376
pii: 333376
pmc: PMC8502009
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1419-1425Informations de copyright
© 2021 Dass et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
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