Bariatric Surgery Induces a Differential Effect on Plasma Aldosterone in Comparison to Dietary Advice Alone.

Adult Aldosterone / blood Bariatric Surgery Blood Pressure Blood Pressure Monitoring, Ambulatory Case-Control Studies Electrolytes / urine Female Humans Male Middle Aged Obesity / diet therapy Prospective Studies Renin / blood Sodium / urine Weight Loss
bariatric-surgery hypertension obesity renin-angiotensin-aldosterone system sodium excretion

Journal

Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782

Informations de publication

Date de publication:
2021
Historique:
received: 21 07 2021
accepted: 13 09 2021
entrez: 22 10 2021
pubmed: 23 10 2021
medline: 25 2 2022
Statut: epublish

Résumé

The pathophysiological mechanisms linking weight loss to blood pressure (BP) reduction are not completely understood. The objective of this study was to compare the effect of weight loss after Roux-en-Y gastric bypass (RYGB) on BP, renin-angiotensin-aldosterone system (RAAS), and urinary electrolytes excretion to those of dietary advice. This was a case-control prospective study including obese patients referred for RYGB (cases) and obese receiving diet advice only (controls). Ambulatory BP, plasma renin activity (PRA), plasma aldosterone concentration (PAC), and urinary electrolytes were measured before (M0) and after intervention (M3: 3 months and M12: 12 months). Twenty-five patients were included in the RYGB group and twelve patients in the control group. After 12 months, weight loss (-42 ± 11.5 Bariatric-induced weight loss induces a progressive decrease in PAC independently of PRA and sodium excretion. Whether this decrease in PAC affects target organ damage in the long term remains to be determined. ClinicalTrials.gov, identifier NCT02218112.

Sections du résumé

Background and Objectives
The pathophysiological mechanisms linking weight loss to blood pressure (BP) reduction are not completely understood. The objective of this study was to compare the effect of weight loss after Roux-en-Y gastric bypass (RYGB) on BP, renin-angiotensin-aldosterone system (RAAS), and urinary electrolytes excretion to those of dietary advice.
Methods
This was a case-control prospective study including obese patients referred for RYGB (cases) and obese receiving diet advice only (controls). Ambulatory BP, plasma renin activity (PRA), plasma aldosterone concentration (PAC), and urinary electrolytes were measured before (M0) and after intervention (M3: 3 months and M12: 12 months).
Results
Twenty-five patients were included in the RYGB group and twelve patients in the control group. After 12 months, weight loss (-42 ± 11.5
Conclusions
Bariatric-induced weight loss induces a progressive decrease in PAC independently of PRA and sodium excretion. Whether this decrease in PAC affects target organ damage in the long term remains to be determined.
Clinical Trial Registration
ClinicalTrials.gov, identifier NCT02218112.

Identifiants

DOI: 10.3389/fendo.2021.745045 PMID: 34675881 PMC: PMC8525894
pubmed: 34675881
doi: 10.3389/fendo.2021.745045
pmc: PMC8525894
doi:

Substances chimiques

Electrolytes 0
Aldosterone 4964P6T9RB
Sodium 9NEZ333N27
Renin EC 3.4.23.15

Banques de données

ClinicalTrials.gov
['NCT02218112']

Types de publication

Comparative Study Journal Article Observational Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

745045

Informations de copyright

Copyright © 2021 Berney, Vakilzadeh, Maillard, Faouzi, Grouzmann, Bonny, Favre and Wuerzner.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Maxime Berney (M)

Service of Nephrology and Hypertension, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Nima Vakilzadeh (N)

Service of Nephrology and Hypertension, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Marc Maillard (M)

Service of Nephrology and Hypertension, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Mohamed Faouzi (M)

Département de Formation, Recherche et Innovation, Unisanté, University of Lausanne, Lausanne, Switzerland.

Eric Grouzmann (E)

Laboratoire des Catécholamines et Peptides, Service de Biomédecine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Olivier Bonny (O)

Service of Nephrology and Hypertension, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.

Lucie Favre (L)

Service of Endocrinology, Diabetes and Metabolism, Lausanne University Hospital, Lausanne, Switzerland.

Grégoire Wuerzner (G)

Service of Nephrology and Hypertension, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Bariatric Surgery Induces a Differential...
questionsmedicales.fr › Hormones corticosurrénaliennes › Hydroxycorticostéroïdes › 11-Hydroxycorticostéroïdes › Aldostérone › Bariatric Surgery Induces a Differential...
questionsmedicales.fr › Procédures de chirurgie opératoire › Chirurgie bariatrique › Bariatric Surgery Induces a Differential...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Pression sanguine › Bariatric Surgery Induces a Differential...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Monitorage physiologique › Surveillance électronique ambulatoire › Surveillance ambulatoire de la pression artérielle › Bariatric Surgery Induces a Differential...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Bariatric Surgery Induces a Differential...
questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Bariatric Surgery Induces a Differential...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Bariatric Surgery Induces a Differential...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Bariatric Surgery Induces a Differential...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Bariatric Surgery Induces a Differential...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Bariatric Surgery Induces a Differential...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Proprotein convertases › Rénine › Bariatric Surgery Induces a Differential...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux légers › Sodium › Bariatric Surgery Induces a Differential...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Mensurations corporelles › Poids › Modifications du poids corporel › Perte de poids › Bariatric Surgery Induces a Differential...