Alternative Approaches for the Management of Diabetic Foot Ulcers.
alternative therapeutic approaches
antibiofilm
biofilm
chronic wound
diabetic foot
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2021
2021
Historique:
received:
26
07
2021
accepted:
07
09
2021
entrez:
22
10
2021
pubmed:
23
10
2021
medline:
23
10
2021
Statut:
epublish
Résumé
Diabetic foot ulcers (DFU) represent a growing public health problem. The emergence of multidrug-resistant (MDR) bacteria is a complication due to the difficulties in distinguishing between infection and colonization in DFU. Another problem lies in biofilm formation on the skin surface of DFU. Biofilm is an important pathophysiology step in DFU and may contribute to healing delays. Both MDR bacteria and biofilm producing microorganism create hostile conditions to antibiotic action that lead to chronicity of the wound, followed by infection and, in the worst scenario, lower limb amputation. In this context, alternative approaches to antibiotics for the management of DFU would be very welcome. In this review, we discuss current knowledge on biofilm in DFU and we focus on some new alternative solutions for the management of these wounds, such as antibiofilm approaches that could prevent the establishment of microbial biofilms and wound chronicity. These innovative therapeutic strategies could replace or complement the classical strategy for the management of DFU to improve the healing process.
Identifiants
pubmed: 34675910
doi: 10.3389/fmicb.2021.747618
pmc: PMC8524042
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
747618Informations de copyright
Copyright © 2021 Pouget, Dunyach-Remy, Pantel, Boutet-Dubois, Schuldiner, Sotto, Lavigne and Loubet.
Déclaration de conflit d'intérêts
CP is the recipient of a grant from Biofilm Control (Bourse CIFRE). The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Plast Reconstr Surg Glob Open. 2019 Jan 15;7(1):e2047
pubmed: 30859031
Antimicrob Resist Infect Control. 2019 May 16;8:76
pubmed: 31131107
Curr Diabetes Rev. 2013 Jan 1;9(1):7-24
pubmed: 22934545
Int J Antimicrob Agents. 2009 Apr;33(4):343-7
pubmed: 19095413
Int J Oral Sci. 2015 Mar 23;7(1):1-7
pubmed: 25504208
J Tissue Viability. 2006 Nov;16(4):6-10
pubmed: 17153117
Int J Oral Sci. 2014 Dec;6(4):189-94
pubmed: 25257882
Antimicrob Agents Chemother. 2020 Jan 27;64(2):
pubmed: 31712203
Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1895-1900
pubmed: 29432190
Bioengineering (Basel). 2018 Jun 14;5(2):
pubmed: 29903998
APMIS Suppl. 2013 May;(136):1-51
pubmed: 23635385
Antimicrob Agents Chemother. 2017 Jan 24;61(2):
pubmed: 27872074
Diabetes Metab Res Rev. 2016 Jan;32 Suppl 1:2-6
pubmed: 26409930
Peptides. 2006 Jun;27(6):1210-6
pubmed: 16289474
BMC Microbiol. 2020 Jul 9;20(1):204
pubmed: 32646376
FEMS Immunol Med Microbiol. 2010 Aug;59(3):439-46
pubmed: 20528934
Foot Ankle Int. 2015 Sep;36(9):1017-24
pubmed: 25967254
Pathog Dis. 2013 Jun;68(1):8-11
pubmed: 23620228
PLoS One. 2008 Oct 03;3(10):e3326
pubmed: 18833331
J Antimicrob Chemother. 2009 Jul;64(1):94-100
pubmed: 19398455
N Engl J Med. 2017 Jun 15;376(24):2367-2375
pubmed: 28614678
Int Wound J. 2017 Apr;14(2):408-413
pubmed: 27212453
Wounds. 2017 Nov;29(11):346-351
pubmed: 28135201
J Wound Care. 2009 Feb;18(2):54-6
pubmed: 19418781
J Med Microbiol. 2016 Oct;65(10):1092-1099
pubmed: 27498987
Cochrane Database Syst Rev. 2015 Mar 06;(3):CD005083
pubmed: 25742878
BMC Infect Dis. 2018 Aug 2;18(1):361
pubmed: 30068306
Int J Nanomedicine. 2018 Feb 16;13:991-1007
pubmed: 29497293
Mediators Inflamm. 2017;2017:5217967
pubmed: 29213192
Environ Microbiol. 2013 Feb;15(2):334-46
pubmed: 22730907
J Med Microbiol. 2012 Aug;61(Pt 8):1062-1070
pubmed: 22516131
PLoS One. 2019 Jan 31;14(1):e0211055
pubmed: 30703114
J Wound Care. 2015 Jan;24(1):11-22
pubmed: 25543819
J Wound Care. 2017 Mar 1;26(Sup3):S1-S154
pubmed: 28345371
Curr Opin Infect Dis. 2008 Aug;21(4):385-92
pubmed: 18594291
Appl Environ Microbiol. 2015 Jul;81(13):4489-97
pubmed: 25911474
Antimicrob Agents Chemother. 2010 May;54(5):2112-8
pubmed: 20211901
Wounds. 2017 Aug;29(8):1-9
pubmed: 28570251
J Appl Microbiol. 2014 Nov;117(5):1388-99
pubmed: 25175797
J Med Microbiol. 2014 Aug;63(Pt 8):1055-1065
pubmed: 24869663
Ann Surg. 2019 Apr;269(4):756-766
pubmed: 29099398
Int J Pediatr Otorhinolaryngol. 2012 Nov;76(11):1575-8
pubmed: 22884365
Int Wound J. 2019 Apr;16(2):486-491
pubmed: 30604568
J Appl Microbiol. 2008 Dec;105(6):1817-25
pubmed: 19016975
Iran J Pharm Res. 2017 Spring;16(2):661-669
pubmed: 28979320
Wounds. 2018 Mar;30(3):72-78
pubmed: 29584602
J Funct Biomater. 2018 Jan 08;9(1):
pubmed: 29316701
Vasc Health Risk Manag. 2007;3(1):65-76
pubmed: 17583176
Int Wound J. 2018 Oct;15(5):749-755
pubmed: 29869367
Antimicrob Agents Chemother. 2009 Oct;53(10):4357-67
pubmed: 19651903
PLoS One. 2012;7(1):e28737
pubmed: 22242149
Int Wound J. 2013 Apr;10(2):193-9
pubmed: 23136838
Antimicrob Agents Chemother. 2016 Oct 21;60(11):6880-6889
pubmed: 27620475
J Antimicrob Chemother. 2017 Jul 1;72(7):2093-2101
pubmed: 28402558
Sci Rep. 2018 Apr 4;8(1):5621
pubmed: 29618775
Appl Biochem Biotechnol. 2012 Jul;167(6):1778-94
pubmed: 22350933
Photodiagnosis Photodyn Ther. 2014 Sep;11(3):342-50
pubmed: 24814697
Pathog Dis. 2018 Jul 1;76(5):
pubmed: 29860413
Infect Chemother. 2018 Mar;50(1):11-20
pubmed: 29637748
J Wound Care. 2018 May 2;27(5):262-271
pubmed: 29738294
Wound Repair Regen. 2008 Jan-Feb;16(1):37-44
pubmed: 18086294
J Antimicrob Chemother. 2016 Feb;71(2):413-21
pubmed: 26490013
J Diabetes Complications. 2014 Nov-Dec;28(6):850-7
pubmed: 25239451
J Med Microbiol. 2011 Mar;60(Pt 3):300-306
pubmed: 21127154
J Nanobiotechnology. 2018 Jan 10;16(1):2
pubmed: 29321021
PLoS Pathog. 2014 Jun 12;10(6):e1004174
pubmed: 24945495
Biomed Res Int. 2016;2016:7616471
pubmed: 27990437
Burns. 2019 Jun;45(4):914-922
pubmed: 30559055
Biofouling. 2016;32(2):215-25
pubmed: 26838161
J Wound Care. 2017 Jan 2;26(1):20-25
pubmed: 28103163
Antibiotics (Basel). 2018 Oct 02;7(4):
pubmed: 30279396
Adv Wound Care (New Rochelle). 2015 Jul 1;4(7):373-381
pubmed: 26155379
Antimicrob Agents Chemother. 2003 Jun;47(6):1979-83
pubmed: 12760879
Curr Top Med Chem. 2016;16(1):99-129
pubmed: 26139111
Int J Low Extrem Wounds. 2018 Mar;17(1):14-21
pubmed: 29458291
Antimicrob Agents Chemother. 2012 May;56(5):2696-704
pubmed: 22354291
Foods. 2018 Mar 19;7(3):
pubmed: 29562719
Clin Infect Dis. 2005 Jun 1;40(11):1650-6
pubmed: 15889364
J Plast Reconstr Aesthet Surg. 2019 Mar;72(3):427-437
pubmed: 30527709
Pathog Dis. 2019 Mar 1;77(2):
pubmed: 30821815
Front Microbiol. 2018 Aug 02;9:1696
pubmed: 30116226
Antibiotics (Basel). 2014;3(4):509-26
pubmed: 26221537
Wounds. 2017 Jun;29(6):S1-S17
pubmed: 28682297
Microbiol Mol Biol Rev. 2013 Mar;77(1):1-52
pubmed: 23471616
Int J Mol Sci. 2018 Apr 12;19(4):
pubmed: 29649179
Clin Cosmet Investig Dermatol. 2020 Nov 24;13:875-888
pubmed: 33262630
Front Microbiol. 2021 Jun 04;12:701898
pubmed: 34220788
J Antimicrob Chemother. 2019 Apr 1;74(4):894-906
pubmed: 30624737
Int J Biol Macromol. 2016 Jul;88:361-72
pubmed: 27044346
Front Microbiol. 2018 Sep 11;9:2127
pubmed: 30254618
Int J Biol Macromol. 2018 Oct 15;118(Pt A):419-426
pubmed: 29908271
Diabetologia. 2008 May;51(5):747-55
pubmed: 18297261
Appl Environ Microbiol. 2006 Jan;72(1):956-9
pubmed: 16391144
Microbiol Spectr. 2015 Jun;3(3):
pubmed: 26185074
J Hosp Infect. 2016 Feb;92(2):154-60
pubmed: 26597632
Clin Orthop Relat Res. 2012 Oct;470(10):2663-70
pubmed: 22585351
Kaohsiung J Med Sci. 2019 Nov;35(11):686-694
pubmed: 31448873
Evid Based Complement Alternat Med. 2015;2015:246012
pubmed: 25861355
Acta Med Croatica. 2016 Mar;70(1):33-42
pubmed: 27220188
J Cell Physiol. 2019 Jun;234(6):7903-7914
pubmed: 30515810
Cochrane Database Syst Rev. 2017 Jun 14;6:CD011038
pubmed: 28613416
J Bacteriol. 2009 Mar;191(5):1393-403
pubmed: 19074399
Phytother Res. 2012 Sep;26(9):1371-4
pubmed: 22294419
Diabetes Metab Res Rev. 2020 Mar;36 Suppl 1:e3280
pubmed: 32176444
J Antimicrob Chemother. 2018 Feb 1;73(2):494-502
pubmed: 29165561
Burns Trauma. 2015 Jul 22;3:9
pubmed: 27574655
Open Microbiol J. 2017 Apr 28;11:53-62
pubmed: 28553416
Biofouling. 2016 Nov;32(10):1259-1270
pubmed: 27841027
Int J Food Microbiol. 2013 Mar 1;162(1):13-25
pubmed: 23340387
Infect Immun. 2013 Feb;81(2):496-504
pubmed: 23208606
Cochrane Database Syst Rev. 2018 Oct 17;10:CD010318
pubmed: 30328611
Mater Sci Eng C Mater Biol Appl. 2019 May;98:503-514
pubmed: 30813052
Shock. 2020 Nov;54(5):681-687
pubmed: 32496417
Diabetes Metab Res Rev. 2014 Jul;30(5):350-3
pubmed: 24446250
Adv Wound Care (New Rochelle). 2019 Jul 1;8(7):341-354
pubmed: 31737421
Future Microbiol. 2018 May;13:711-726
pubmed: 29792526
Clin Microbiol Rev. 2002 Apr;15(2):167-93
pubmed: 11932229
Cochrane Database Syst Rev. 2015 Jun 24;(6):CD004123
pubmed: 26106870
ACS Chem Biol. 2014 Jan 17;9(1):183-92
pubmed: 24134695
PLoS One. 2011 Apr 07;6(4):e18514
pubmed: 21490923
ACS Cent Sci. 2017 Mar 22;3(3):163-175
pubmed: 28386594
Indian J Microbiol. 2016 Mar;56(1):1-18
pubmed: 26843692
Microbiol Spectr. 2015 Jun;3(3):
pubmed: 26185072
Lancet Diabetes Endocrinol. 2018 Mar;6(3):186-196
pubmed: 29275068
J Mater Sci Mater Med. 2018 Feb 02;29(3):22
pubmed: 29396683
Artif Cells Nanomed Biotechnol. 2018 Feb;46(1):95-107
pubmed: 28830269