The Partitioning of Newly Assimilated Linoleic and α-Linolenic Acids Between Synthesis of Longer-Chain Polyunsaturated Fatty Acids and Hydroxyoctadecaenoic Acids Is a Putative Branch Point in T-Cell Essential Fatty Acid Metabolism.
Adolescent
Adult
Cells, Cultured
Fatty Acid Desaturases
/ metabolism
Fatty Acid Elongases
/ metabolism
Fatty Acids, Essential
/ metabolism
Fatty Acids, Unsaturated
/ metabolism
Female
Gas Chromatography-Mass Spectrometry
Humans
Linoleic Acid
/ metabolism
Lipid Metabolism
Lymphocyte Activation
Male
T-Lymphocytes
/ metabolism
Young Adult
alpha-Linolenic Acid
/ metabolism
ELOVL5
FADS2
T lymphocyte
desaturase
elongase
omega-3 and omega-6 polyunsaturated fatty acids
oxylipin
stable isotope
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
13
07
2021
accepted:
08
09
2021
entrez:
22
10
2021
pubmed:
23
10
2021
medline:
6
1
2022
Statut:
epublish
Résumé
Longer-chain polyunsaturated fatty acids (LCPUFAs) ≥20 carbons long are required for leukocyte function. These can be obtained from the diet, but there is some evidence that leukocytes can convert essential fatty acids (EFAs) into LCPUFAs. We used stable isotope tracers to investigate LCPUFA biosynthesis and the effect of different EFA substrate ratios in human T lymphocytes. CD3
Identifiants
pubmed: 34675928
doi: 10.3389/fimmu.2021.740749
pmc: PMC8523940
doi:
Substances chimiques
ELOVL5 protein, human
0
Fatty Acids, Essential
0
Fatty Acids, Unsaturated
0
hydroxyoctadecadienoic acid
0
alpha-Linolenic Acid
0RBV727H71
Linoleic Acid
9KJL21T0QJ
Fatty Acid Desaturases
EC 1.14.19.-
FADS2 protein, human
EC 1.14.19.3
Fatty Acid Elongases
EC 2.3.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
740749Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/S00548X/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/S005358/1
Pays : United Kingdom
Informations de copyright
Copyright © 2021 von Gerichten, West, Irvine, Miles, Calder, Lillycrop, Fielding and Burdge.
Déclaration de conflit d'intérêts
GB has received research funding from Nestle, Abbott Nutrition, and Danone and has served as a member of the Scientific Advisory Board of BASF. PC acts as a consultant to BASF, Smartfish, DSM, Cargill, Danone/Nutricia, and Fresenius-Kabi. KL has received research funding from Nestle, Abbott Nutrition, and Danone. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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