Intramolecular Ring-Opening Decomposition of Aryl Azetidines.
Journal
ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073
Informations de publication
Date de publication:
14 Oct 2021
14 Oct 2021
Historique:
received:
25
07
2021
accepted:
28
09
2021
entrez:
22
10
2021
pubmed:
23
10
2021
medline:
23
10
2021
Statut:
epublish
Résumé
The ring strain present in azetidines can lead to undesired stability issues. Herein, we described a series of N-substituted azetidines which undergo an acid-mediated intramolecular ring-opening decomposition via nucleophilic attack of a pendant amide group. Studies were conducted to understand the decomposition mechanism enabling the design of stable analogues.
Identifiants
pubmed: 34676040
doi: 10.1021/acsmedchemlett.1c00402
pmc: PMC8521649
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1585-1588Informations de copyright
© 2021 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare the following competing financial interest(s): All authors were employees and stockholders of Pfizer during the time this work was completed.
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